ENSMUSG00000000617


Mus musculus

Features
Gene ID: ENSMUSG00000000617
  
Biological name :Grm6
  
Synonyms : Grm6 / Metabotropic glutamate receptor 6 / Q5NCH9
  
Possible biological names infered from orthology : glutamate metabotropic receptor 6 / O15303
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.3
Gene start: 50850685
Gene end: 50866208
  
Corresponding Affymetrix probe sets: 10375774 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000000631
Ensembl peptide - ENSMUSP00000130728
NCBI entrez gene - 108072     See in Manteia.
MGI - MGI:1351343
RefSeq - XM_006531961
RefSeq - NM_173372
RefSeq Peptide - NP_775548
swissprot - Q5NCH9
Ensembl - ENSMUSG00000000617
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grm6aENSDARG00000017742Danio rerio
 grm6bENSDARG00000025671Danio rerio
 GRM6ENSG00000113262Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grm8 / P47743 / glutamate receptor, metabotropic 8 / O00222* / glutamate metabotropic receptor 8*ENSMUSG0000002421169
Grm4 / glutamate receptor, metabotropic 4 / Q14833* / glutamate metabotropic receptor 4*ENSMUSG0000006323969
Grm7 / Q68ED2 / Metabotropic glutamate receptor 7 / Q14831* / glutamate metabotropic receptor 7*ENSMUSG0000005675566
Grm2 / Q14BI2 / Metabotropic glutamate receptor 2 / Q14416* / glutamate metabotropic receptor 2*ENSMUSG0000002319245
Grm3 / Q9QYS2 / Metabotropic glutamate receptor 3 / Q14832* / glutamate metabotropic receptor 3*ENSMUSG0000000397444
Grm1 / P97772 / Metabotropic glutamate receptor 1 / Q13255* / glutamate metabotropic receptor 1*ENSMUSG0000001982840
Grm5 / Q3UVX5 / glutamate receptor, metabotropic 5 / P41594* / glutamate metabotropic receptor 5*ENSMUSG0000004958340
Q925I4 / Tas1r2 / taste receptor, type 1, member 2 / Q8TE23* / taste 1 receptor member 2*ENSMUSG0000002873824
Gprc6a / Q8K4Z6 / G protein-coupled receptor, family C, group 6, member A / Q5T6X5* / G protein-coupled receptor class C group 6 member A*ENSMUSG0000001990524
Q925D8 / Tas1r3 / Taste receptor type 1 member 3 / Q7RTX0* / taste 1 receptor member 3*ENSMUSG0000002907223
Tas1r1 / taste receptor, type 1, member 1 / Q7RTX1* / taste 1 receptor member 1*ENSMUSG0000002895021


Protein motifs (from Interpro)
Interpro ID Name
 IPR000112  GPCR, family 3, metabotropic glutamate receptor 6
 IPR000162  GPCR, family 3, metabotropic glutamate receptor
 IPR000337  GPCR, family 3
 IPR001828  Receptor, ligand binding region
 IPR011500  GPCR, family 3, nine cysteines domain
 IPR017978  GPCR family 3, C-terminal
 IPR017979  GPCR, family 3, conserved site
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IGI
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway IEA
 biological_processGO:0007216 G-protein coupled glutamate receptor signaling pathway IEA
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0007601 visual perception TAS
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0050908 detection of light stimulus involved in visual perception IEA
 biological_processGO:0050953 sensory perception of light stimulus IMP
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IBA
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0090280 positive regulation of calcium ion import IEA
 cellular_componentGO:0000139 Golgi membrane ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0035841 new growing cell tip IDA
 cellular_componentGO:0042734 presynaptic membrane IBA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045211 postsynaptic membrane TAS
 molecular_functionGO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity IEA
 molecular_functionGO:0001642 group III metabotropic glutamate receptor activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0008066 glutamate receptor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0002546 mydriasis "dilation of one or both pupils" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nf1tm1Fcr/Nf1tm1.1Par
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Mogtm1(cre)Gkl/Mog+
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Grm6nob4/Grm6nob4
Genetic Background: involves: C57BL/6J

Allelic Composition: Grm6nob3/Grm6nob3
Genetic Background: B6.B10(D2)-Grm6nob3/Pjn

Allelic Composition: Gpr179nob5/Gpr179+,Grm6nob3/Grm6+
Genetic Background: involves: C3H * C57BL/10

Allelic Composition: Grm6nob7/Grm6nob7
Genetic Background: C57BL/6J-Grm6nob7

Allelic Composition: Grm6nob3/Grm6nob7
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Mogtm1(cre)Gkl/Mog+
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Grm6nob4/Grm6nob4
Genetic Background: involves: C57BL/6J

Allelic Composition: Grm6nob3/Grm6nob3
Genetic Background: B6.B10(D2)-Grm6nob3/Pjn

Allelic Composition: Grm6nob7/Grm6nob7
Genetic Background: C57BL/6J-Grm6nob7

Allelic Composition: Grm6nob3/Grm6nob7
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Mogtm1(cre)Gkl/Mog+
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Grm6nob4/Grm6nob4
Genetic Background: involves: C57BL/6J

Allelic Composition: Grm6nob3/Grm6nob3
Genetic Background: B6.B10(D2)-Grm6nob3/Pjn

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Nf1tm1Fcr/Nf1tm1.1Par
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Allelic Composition: Grm6nob4/Grm6nob4
Genetic Background: C57BL/6J-Grm6nob4

Allelic Composition: Grm6tm1Nak/Grm6tm1Nak
Genetic Background: involves: 129S/SvEv

 MP:0006243 abnormal pupil dilation reaction to light "the pupil fails to constrict fully when exposed to bright light" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0012144 decreased b wave amplitude "reduction in the size (height or maximum displacement) of the b wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Grm6nob7/Grm6nob7
Genetic Background: C57BL/6J-Grm6nob7

Allelic Composition: Grm6nob3/Grm6nob7
Genetic Background: involves: C57BL/6J * C57BL/10J

Allelic Composition: Grm6nob8/Grm6nob8
Genetic Background: CBA/CaJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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