ENSMUSG00000019828


Mus musculus

Features
Gene ID: ENSMUSG00000019828
  
Biological name :Grm1
  
Synonyms : Grm1 / Metabotropic glutamate receptor 1 / P97772
  
Possible biological names infered from orthology : glutamate metabotropic receptor 1 / Q13255
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: A1
Gene start: 10686059
Gene end: 11082356
  
Corresponding Affymetrix probe sets: 10367828 (MoGene1.0st)   10367830 (MoGene1.0st)   1425700_at (Mouse Genome 430 2.0 Array)   1440545_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037255
Ensembl peptide - ENSMUSP00000101189
Ensembl peptide - ENSMUSP00000101190
NCBI entrez gene - 14816     See in Manteia.
MGI - MGI:1351338
RefSeq - XM_006512554
RefSeq - NM_001114333
RefSeq - NM_016976
RefSeq - XM_006512549
RefSeq - XM_006512550
RefSeq - XM_006512551
RefSeq Peptide - NP_058672
RefSeq Peptide - NP_001107805
swissprot - P97772
Ensembl - ENSMUSG00000019828
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grm1aENSDARG00000026796Danio rerio
 grm1bENSDARG00000098320Danio rerio
 GRM1ENSGALG00000012297Gallus gallus
 GRM1ENSG00000152822Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grm5 / Q3UVX5 / glutamate receptor, metabotropic 5 / P41594* / glutamate metabotropic receptor 5*ENSMUSG0000004958361
Grm2 / Q14BI2 / Metabotropic glutamate receptor 2 / Q14416* / glutamate metabotropic receptor 2*ENSMUSG0000002319232
Grm8 / P47743 / glutamate receptor, metabotropic 8 / O00222* / glutamate metabotropic receptor 8*ENSMUSG0000002421131
Grm3 / Q9QYS2 / Metabotropic glutamate receptor 3 / Q14832* / glutamate metabotropic receptor 3*ENSMUSG0000000397431
Grm4 / glutamate receptor, metabotropic 4 / Q14833* / glutamate metabotropic receptor 4*ENSMUSG0000006323930
Grm7 / Q68ED2 / Metabotropic glutamate receptor 7 / Q14831* / glutamate metabotropic receptor 7*ENSMUSG0000005675530
Grm6 / Q5NCH9 / Metabotropic glutamate receptor 6 / O15303* / glutamate metabotropic receptor 6*ENSMUSG0000000061729
Gprc6a / Q8K4Z6 / G protein-coupled receptor, family C, group 6, member A / Q5T6X5* / G protein-coupled receptor class C group 6 member A*ENSMUSG0000001990518
Tas1r1 / taste receptor, type 1, member 1 / Q7RTX1* / taste 1 receptor member 1*ENSMUSG0000002895017
Q925D8 / Tas1r3 / Taste receptor type 1 member 3 / Q7RTX0* / taste 1 receptor member 3*ENSMUSG0000002907216
Q925I4 / Tas1r2 / taste receptor, type 1, member 2 / Q8TE23* / taste 1 receptor member 2*ENSMUSG0000002873816


Protein motifs (from Interpro)
Interpro ID Name
 IPR000162  GPCR, family 3, metabotropic glutamate receptor
 IPR000337  GPCR, family 3
 IPR001256  GPCR, family 3, metabotropic glutamate receptor 1
 IPR001828  Receptor, ligand binding region
 IPR011500  GPCR, family 3, nine cysteines domain
 IPR017978  GPCR family 3, C-terminal
 IPR017979  GPCR, family 3, conserved site
 IPR019588  Metabotropic glutamate receptor, Homer-binding domain
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IDA
 biological_processGO:0000187 activation of MAPK activity IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway IBA
 biological_processGO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway IEA
 biological_processGO:0007216 G-protein coupled glutamate receptor signaling pathway ISS
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0043408 regulation of MAPK cascade IDA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway ISS
 biological_processGO:0051930 regulation of sensory perception of pain IDA
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IBA
 biological_processGO:0071257 cellular response to electrical stimulus IMP
 biological_processGO:0099566 regulation of postsynaptic cytosolic calcium ion concentration IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0038037 G-protein coupled receptor dimeric complex ISO
 cellular_componentGO:0038038 G-protein coupled receptor homodimeric complex ISO
 cellular_componentGO:0042734 presynaptic membrane IBA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body TAS
 cellular_componentGO:0045211 postsynaptic membrane TAS
 molecular_functionGO:0001639 PLC activating G-protein coupled glutamate receptor activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008066 glutamate receptor activity ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration IMP


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
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Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Grm1tm1Dgen/Grm1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000069 kyphoscoliosis "kyphosis combined with scoliosis" [MGI:CML, J:66943]
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Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Grm1m1Btlr/Grm1m1Btlr
Genetic Background: C57BL/6J-Grm1m1Btlr

 MP:0000743 muscle spasms "muscular twitching, cramps and seizures ; frequently associated with calcium deficiency, hypoparathyroidism, vitamin D deficiency or alkalosis " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fgf8tm1.2Mrt/Fgf8tm1.4Mrt
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Grm1tm1Stl/Grm1tm1Stl
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Grm1nmf373/Grm1nmf373
Genetic Background: C57BL/6J-Grm1nmf373/J

Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Grm1tm1Dgen/Grm1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001188 hyperpigmentation "excess of pigment in any or all tissues or a part of a tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm1Mmt/Ctnnb1+
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Grm1tm1Dgen/Grm1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Zic5tm1Sia/Zic5tm1Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Grm1rcw-3J/Grm1rcw-3J
Genetic Background: C57BL/6J-Grm1rcw-3J/GrsrJ

Allelic Composition: Grm1tm1Dgen/Grm1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grm1rcw-4J/Grm1rcw-4J
Genetic Background: C57BL/6J-Grm1rcw-4J/GrsrJ

Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Grm1rcw-2J/Grm1rcw-2J
Genetic Background: either: B6(129X1)-Grm1rcw-2J/J or B6.129X1 Baxtm1Sjk/J-Grm1rcw-2J/J

Allelic Composition: Grm1rcw-4J/Grm1rcw-4J
Genetic Background: C57BL/6J-Grm1rcw-4J/GrsrJ

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Fgf8tm1.2Mrt/Fgf8tm1.4Mrt
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Grm1tm1Stl/Grm1tm1Stl
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Grm1rcw-2J/Grm1rcw-2J
Genetic Background: either: B6(129X1)-Grm1rcw-2J/J or B6.129X1 Baxtm1Sjk/J-Grm1rcw-2J/J

Allelic Composition: Grm1rcw-3J/Grm1rcw-3J
Genetic Background: C57BL/6J-Grm1rcw-3J/GrsrJ

Allelic Composition: Grm1tm1Dgen/Grm1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grm1nmf373/Grm1nmf373
Genetic Background: C57BL/6J-Grm1nmf373/J

Allelic Composition: Grm1wobl/Grm1wobl
Genetic Background: C57BL/6Apb-Grm1wobl/Apb

Allelic Composition: Grm1rcw-4J/Grm1rcw-4J
Genetic Background: C57BL/6J-Grm1rcw-4J/GrsrJ

Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

Allelic Composition: Grm1m1Btlr/Grm1m1Btlr
Genetic Background: C57BL/6J-Grm1m1Btlr

Allelic Composition: Grm1tvrm84/Grm1tvrm84
Genetic Background: C57BL/6J-Grm1tvrm84/Pjn

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Grm1tm1Dgen/Grm1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

Allelic Composition: Grm1tm1Stl/Grm1tm1Stl,Pcp2tm1(tTA)23Atai/Pcp2+,Tg(tetO-Grm1)7Atai/?
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Fgf8tm1.2Mrt/Fgf8tm1.4Mrt
Genetic Background: involves: 129P2/OlaHsd

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Fgf8tm1.2Mrt/Fgf8tm1.4Mrt
Genetic Background: involves: 129P2/OlaHsd

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Fgf8tm1.2Mrt/Fgf8tm1.3Mrt,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Fgf8tm1.2Mrt/Fgf8tm1.4Mrt
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Grm1tm1Stl/Grm1tm1Stl
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Grm1tm1Crpl/Grm1tm1Crpl
Genetic Background: Not Specified

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Fgf8tm1.2Mrt/Fgf8tm1.4Mrt
Genetic Background: involves: 129P2/OlaHsd

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Grm1tm1Dgen/Grm1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

Allelic Composition: Grm1nmf373/Grm1nmf373
Genetic Background: C57BL/6J-Grm1nmf373/J

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Runx2tm1Gss/Runx2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Fgf8tm1.2Mrt/Fgf8tm1.4Mrt
Genetic Background: involves: 129P2/OlaHsd

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Grm1tm1Dgen/Grm1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Grm1tm1Stl/Grm1tm1Stl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grm1tm1Dgen/Grm1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grm1m1Btlr/Grm1m1Btlr
Genetic Background: C57BL/6J-Grm1m1Btlr

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Muc2wnn/Muc2wnn
Genetic Background: C57BL/6-Muc2wnn

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mchr1tm1Blak/Mchr1tm1Blak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Grm1rcw-4J/Grm1rcw-4J
Genetic Background: C57BL/6J-Grm1rcw-4J/GrsrJ

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zic5tm1Sia/Zic5tm1Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Grm1rcw-4J/Grm1rcw-4J
Genetic Background: C57BL/6J-Grm1rcw-4J/GrsrJ

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

Allelic Composition: Grm1crv4/Grm1+
Genetic Background: BALB/cPas-Grm1crv4

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Grm1tm1Stl/Grm1tm1Stl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grm1tm1Stl/Grm1tm1Stl,Pcp2tm1(tTA)23Atai/Pcp2+,Tg(tetO-Grm1)7Atai/?
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

 MP:0005287 narrow eye opening "less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350]
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Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

 MP:0005326 abnormal podocytes "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]
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Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

Allelic Composition: Grm1crv4/Grm1+
Genetic Background: BALB/cPas-Grm1crv4

 MP:0008140 podocyte foot process effacement "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

Allelic Composition: Grm1crv4/Grm1+
Genetic Background: BALB/cPas-Grm1crv4

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grm1tm1Dgen/Grm1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010322 increased cutaneous melanoma incidence "greater than the expected number of a dark-pigmented, usually malignant tumor arising from a melanocyte in the skin, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm1Mmt/Ctnnb1+
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0010741 abnormal melanocyte proliferation "anomaly in the ability of the a melanocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm1Mmt/Ctnnb1+
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0011348 abnormal renal glomerulus basement membrane morphology "any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna]
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Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

 MP:0011402 renal cast "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]
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Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
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Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

Allelic Composition: Grm1crv4/Grm1+
Genetic Background: BALB/cPas-Grm1crv4

 MP:0011856 abnormal glomerular filtration barrier function "anomaly in the function of the highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules; its integrity is maintained by physicochemical and signalling interplay among its three core constituents -- the fenestrated endothelium of the glomerular capillaries, the glomerular basement membrane, and the filtration slits of the visceral epithelial cell (podocyte); the barrier permits the passage of water, ions, and small molecules from the bloodstream into the Bowman s space and prevents the loss of large and/or negatively charged proteins (e.g. serum albumin) from blood into urine" [MGI:anna]
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Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

 MP:0012029 abnormal electroretinogram waveform feature "any anomaly in the pattern of the graphic record of the integrated ensemble response from many vision related neuronal and glial populations as a consequence of the serial processing within the retina, represented as changes in voltage over time after visual photonic stimulation" [MGI:csmith]
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Allelic Composition: Grm1tvrm84/Grm1tvrm84
Genetic Background: C57BL/6J-Grm1tvrm84/Pjn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003573 Homer3 / Q99JP6 / Homer protein homolog 3 / Q9NSC5* / homer scaffolding protein 3*  / reaction / complex
 ENSMUSG00000025813 Homer2 / Q9QWW1 / Homer protein homolog 2 / Q9NSB8* / homer scaffolding protein 2*  / complex / reaction
 ENSMUSG00000007617 Homer1 / Q9Z2Y3 / Homer protein homolog 1 / Q86YM7* / homer scaffolding protein 1*  / reaction / complex






 

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