ENSMUSG00000007617


Mus musculus

Features
Gene ID: ENSMUSG00000007617
  
Biological name :Homer1
  
Synonyms : Homer1 / Homer protein homolog 1 / Q9Z2Y3
  
Possible biological names infered from orthology : homer scaffolding protein 1 / Q86YM7
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: C3
Gene start: 93299635
Gene end: 93405129
  
Corresponding Affymetrix probe sets: 10406626 (MoGene1.0st)   1421768_a_at (Mouse Genome 430 2.0 Array)   1425671_at (Mouse Genome 430 2.0 Array)   1425710_a_at (Mouse Genome 430 2.0 Array)   1436387_at (Mouse Genome 430 2.0 Array)   1437363_at (Mouse Genome 430 2.0 Array)   1439662_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105119
Ensembl peptide - ENSMUSP00000105124
Ensembl peptide - ENSMUSP00000105123
Ensembl peptide - ENSMUSP00000105122
Ensembl peptide - ENSMUSP00000105121
Ensembl peptide - ENSMUSP00000105120
Ensembl peptide - ENSMUSP00000050471
Ensembl peptide - ENSMUSP00000078093
Ensembl peptide - ENSMUSP00000079026
Ensembl peptide - ENSMUSP00000099813
Ensembl peptide - ENSMUSP00000105118
NCBI entrez gene - 26556     See in Manteia.
MGI - MGI:1347345
RefSeq - XM_017315518
RefSeq - NM_001284189
RefSeq - NM_011982
RefSeq - NM_147176
RefSeq - NM_152134
RefSeq Peptide - NP_687036
RefSeq Peptide - NP_001271118
RefSeq Peptide - NP_001334527
RefSeq Peptide - NP_036112
RefSeq Peptide - NP_671705
swissprot - D3Z6A8
swissprot - D3Z6A7
swissprot - Q3UVL6
swissprot - E9Q0I7
swissprot - Q5D052
swissprot - Q9Z2Y3
swissprot - E9Q0I8
swissprot - D3Z6A9
Ensembl - ENSMUSG00000007617
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 homer1bENSDARG00000101759Danio rerio
 HOMER1ENSGALG00000014813Gallus gallus
 HOMER1ENSG00000152413Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Homer2 / Q9QWW1 / Homer protein homolog 2 / Q9NSB8* / homer scaffolding protein 2*ENSMUSG0000002581348
Homer3 / Q99JP6 / Homer protein homolog 3 / Q9NSC5* / homer scaffolding protein 3*ENSMUSG0000000357347


Protein motifs (from Interpro)
Interpro ID Name
 IPR000697  WH1/EVH1 domain
 IPR011993  PH-like domain superfamily
 IPR019394  Testis-specific protein TEX28/transmembrane and coiled-coil domains protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003009 skeletal muscle contraction IMP
 biological_processGO:0007216 G-protein coupled glutamate receptor signaling pathway TAS
 biological_processGO:0048148 behavioral response to cocaine IMP
 biological_processGO:0048741 skeletal muscle fiber development IMP
 biological_processGO:0048875 chemical homeostasis within a tissue IMP
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0051928 positive regulation of calcium ion transport IMP
 biological_processGO:0090279 regulation of calcium ion import IMP
 biological_processGO:2001256 regulation of store-operated calcium entry IMP
 biological_processGO:2001257 regulation of cation channel activity IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0014069 postsynaptic density IMP
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0043005 neuron projection IMP
 cellular_componentGO:0043034 costamere IDA
 cellular_componentGO:0045177 apical part of cell IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0098794 postsynapse IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035256 G-protein coupled glutamate receptor binding IBA
 molecular_functionGO:0044325 ion channel binding IEA


Pathways (from Reactome)
Pathway description
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001968 abnormal touch/ nociception "change in the ability to sense contact with objects or in the ability to sense pain, most often registered by mechanoreceptors in the skin and mucous membranes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zfp148Gt(XB878)Byg/Zfp148Gt(XB878)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002693 abnormal pancreas physiology "abberrant function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gabbr1tm2Bet/Gabbr1tm2Bet,Hdctm1.1(icre)Wwis/Hdc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Hgftm1Jmw/Hgftm1Jmw,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ay/A
Genetic Background: involves: C3H/HeJ * C57BL/6J-Ay/a

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zfp148Gt(XB878)Byg/Zfp148Gt(XB878)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008432 abnormal long-term spatial reference memory "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zfp148Gt(XB878)Byg/Zfp148Gt(XB878)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ay/A
Genetic Background: involves: C3H/HeJ * C57BL/6J-Ay/a

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Zfp148Gt(XB878)Byg/Zfp148Gt(XB878)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009713 enhanced conditioned place preference behavior "increase in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hgftm1Jmw/Hgftm1Jmw,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0009754 enhanced behavioral response to cocaine "increased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hgftm1Jmw/Hgftm1Jmw,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003573 Homer3 / Q99JP6 / Homer protein homolog 3 / Q9NSC5* / homer scaffolding protein 3*  / complex / reaction
 ENSMUSG00000049583 Grm5 / Q3UVX5 / glutamate receptor, metabotropic 5 / P41594* / glutamate metabotropic receptor 5*  / complex / reaction
 ENSMUSG00000019828 Grm1 / P97772 / Metabotropic glutamate receptor 1 / Q13255* / glutamate metabotropic receptor 1*  / complex / reaction
 ENSMUSG00000025813 Homer2 / Q9QWW1 / Homer protein homolog 2 / Q9NSB8* / homer scaffolding protein 2*  / reaction / complex
 ENSMUSG00000007617 Homer1 / Q9Z2Y3 / Homer protein homolog 1 / Q86YM7* / homer scaffolding protein 1*  / complex / reaction






 

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