ENSMUSG00000025813


Mus musculus

Features
Gene ID: ENSMUSG00000025813
  
Biological name :Homer2
  
Synonyms : Homer2 / Homer protein homolog 2 / Q9QWW1
  
Possible biological names infered from orthology : homer scaffolding protein 2 / Q9NSB8
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: D3
Gene start: 81600481
Gene end: 81707527
  
Corresponding Affymetrix probe sets: 10565152 (MoGene1.0st)   10565156 (MoGene1.0st)   1424367_a_at (Mouse Genome 430 2.0 Array)   1436110_at (Mouse Genome 430 2.0 Array)   1457671_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146521
Ensembl peptide - ENSMUSP00000147030
Ensembl peptide - ENSMUSP00000146787
Ensembl peptide - ENSMUSP00000026922
Ensembl peptide - ENSMUSP00000095931
NCBI entrez gene - 26557     See in Manteia.
MGI - MGI:1347354
RefSeq - XM_006540909
RefSeq - NM_001164086
RefSeq - NM_001164087
RefSeq - NM_011983
RefSeq Peptide - NP_001157559
RefSeq Peptide - NP_001157558
RefSeq Peptide - NP_036113
swissprot - Q9QWW1
swissprot - A0A140LJ06
swissprot - E9Q4F9
swissprot - A0A140LHR9
Ensembl - ENSMUSG00000025813
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 homer2ENSDARG00000059349Danio rerio
 HOMER2ENSGALG00000006008Gallus gallus
 HOMER2ENSG00000103942Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Homer1 / Q9Z2Y3 / Homer protein homolog 1 / Q86YM7* / homer scaffolding protein 1*ENSMUSG0000000761751
Homer3 / Q99JP6 / Homer protein homolog 3 / Q9NSC5* / homer scaffolding protein 3*ENSMUSG0000000357346


Protein motifs (from Interpro)
Interpro ID Name
 IPR000697  WH1/EVH1 domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007216 G-protein coupled glutamate receptor signaling pathway TAS
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IDA
 biological_processGO:0035584 calcium-mediated signaling using intracellular calcium source IMP
 biological_processGO:0048148 behavioral response to cocaine IMP
 biological_processGO:0048875 chemical homeostasis within a tissue IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0032420 stereocilium IEA
 cellular_componentGO:0032426 stereocilium tip IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045177 apical part of cell IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0003779 actin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030160 GKAP/Homer scaffold activity IDA
 molecular_functionGO:0035254 glutamate receptor binding IEA
 molecular_functionGO:0035256 G-protein coupled glutamate receptor binding IBA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002062 abnormal conditioning behavior "inability to change the frequency or form of a behavior as a result of the influence of the environment " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hgftm1Jmw/Hgftm1Jmw,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0002556 cocaine consumption 
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Allelic Composition: Hgftm1Jmw/Hgftm1Jmw,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0002693 abnormal pancreas physiology "abberrant function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gabbr1tm2Bet/Gabbr1tm2Bet,Hdctm1.1(icre)Wwis/Hdc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Hgftm1Jmw/Hgftm1Jmw,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0009713 enhanced conditioned place preference behavior "increase in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hgftm1Jmw/Hgftm1Jmw,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0009754 enhanced behavioral response to cocaine "increased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hgftm1Jmw/Hgftm1Jmw,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003573 Homer3 / Q99JP6 / Homer protein homolog 3 / Q9NSC5* / homer scaffolding protein 3*  / complex / reaction
 ENSMUSG00000049583 Grm5 / Q3UVX5 / glutamate receptor, metabotropic 5 / P41594* / glutamate metabotropic receptor 5*  / reaction / complex
 ENSMUSG00000025813 Homer2 / Q9QWW1 / Homer protein homolog 2 / Q9NSB8* / homer scaffolding protein 2*  / reaction / complex
 ENSMUSG00000019828 Grm1 / P97772 / Metabotropic glutamate receptor 1 / Q13255* / glutamate metabotropic receptor 1*  / reaction / complex
 ENSMUSG00000007617 Homer1 / Q9Z2Y3 / Homer protein homolog 1 / Q86YM7* / homer scaffolding protein 1*  / complex / reaction






 

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