ENSG00000179603


Homo sapiens

Features
Gene ID: ENSG00000179603
  
Biological name :GRM8
  
Synonyms : glutamate metabotropic receptor 8 / GRM8 / O00222
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q31.33
Gene start: 126438598
Gene end: 127253294
  
Corresponding Affymetrix probe sets: 216255_s_at (Human Genome U133 Plus 2.0 Array)   216256_at (Human Genome U133 Plus 2.0 Array)   216992_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000409790
Ensembl peptide - ENSP00000398012
Ensembl peptide - ENSP00000415522
Ensembl peptide - ENSP00000419832
Ensembl peptide - ENSP00000418255
Ensembl peptide - ENSP00000344173
Ensembl peptide - ENSP00000345747
Ensembl peptide - ENSP00000351142
NCBI entrez gene - 2918     See in Manteia.
OMIM - 601116
RefSeq - XM_017012080
RefSeq - XM_011516103
RefSeq - XM_017012074
RefSeq - XM_017012075
RefSeq - XM_017012076
RefSeq - XM_017012077
RefSeq - XM_017012078
RefSeq - XM_017012079
RefSeq - NM_000845
RefSeq - NM_001127323
RefSeq - XM_006715938
RefSeq - XM_011516091
RefSeq - XM_011516092
RefSeq - XM_011516094
RefSeq - XM_011516095
RefSeq - XM_011516101
RefSeq - XM_011516102
RefSeq Peptide - NP_000836
RefSeq Peptide - NP_001120795
swissprot - H7C4V5
swissprot - E7ETK3
swissprot - A0A0A0MT06
swissprot - O00222
swissprot - C9J7I1
Ensembl - ENSG00000179603
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grm8aENSDARG00000077654Danio rerio
 grm8bENSDARG00000076508Danio rerio
 GRM8ENSGALG00000039403Gallus gallus
 Grm8ENSMUSG00000024211Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRM4 / Q14833 / glutamate metabotropic receptor 4ENSG0000012449375
GRM7 / Q14831 / glutamate metabotropic receptor 7ENSG0000019627774
GRM6 / O15303 / glutamate metabotropic receptor 6ENSG0000011326267
GRM3 / Q14832 / glutamate metabotropic receptor 3ENSG0000019882244
GRM2 / Q14416 / glutamate metabotropic receptor 2ENSG0000016408244
GRM5 / P41594 / glutamate metabotropic receptor 5ENSG0000016895942
GRM1 / Q13255 / glutamate metabotropic receptor 1ENSG0000015282241
GPRC6A / Q5T6X5 / G protein-coupled receptor class C group 6 member AENSG0000017361223
Q8TE23 / TAS1R2 / taste 1 receptor member 2ENSG0000017900221
Q7RTX1 / TAS1R1 / taste 1 receptor member 1ENSG0000017366221
Q7RTX0 / TAS1R3 / taste 1 receptor member 3ENSG0000016996220


Protein motifs (from Interpro)
Interpro ID Name
 IPR000144  GPCR, family 3, metabotropic glutamate receptor 8
 IPR000162  GPCR, family 3, metabotropic glutamate receptor
 IPR000337  GPCR, family 3
 IPR001786  GPCR, family 3, metabotropic glutamate receptor 4
 IPR001828  Receptor, ligand binding region
 IPR011500  GPCR, family 3, nine cysteines domain
 IPR017978  GPCR family 3, C-terminal
 IPR017979  GPCR, family 3, conserved site
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway IMP
 biological_processGO:0007601 visual perception TAS
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042734 presynaptic membrane IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0008066 glutamate receptor activity IMP


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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