ENSG00000124493


Homo sapiens

Features
Gene ID: ENSG00000124493
  
Biological name :GRM4
  
Synonyms : glutamate metabotropic receptor 4 / GRM4 / Q14833
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.31
Gene start: 34018645
Gene end: 34155622
  
Corresponding Affymetrix probe sets: 210234_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000476561
Ensembl peptide - ENSP00000440556
Ensembl peptide - ENSP00000477016
Ensembl peptide - ENSP00000477466
Ensembl peptide - ENSP00000363292
Ensembl peptide - ENSP00000363296
Ensembl peptide - ENSP00000398456
Ensembl peptide - ENSP00000437730
Ensembl peptide - ENSP00000437925
NCBI entrez gene - 2914     See in Manteia.
OMIM - 604100
RefSeq - XM_017010793
RefSeq - NM_000841
RefSeq - NM_001256809
RefSeq - NM_001256811
RefSeq - NM_001256812
RefSeq - NM_001256813
RefSeq - NM_001282847
RefSeq - XM_017010790
RefSeq - XM_017010791
RefSeq - XM_017010792
RefSeq Peptide - NP_001243740
RefSeq Peptide - NP_001243741
RefSeq Peptide - NP_001243742
RefSeq Peptide - NP_001269776
RefSeq Peptide - NP_000832
RefSeq Peptide - NP_001243738
swissprot - V9GYB0
swissprot - B7ZLU9
swissprot - V9GYR3
swissprot - A1L4F9
swissprot - Q14833
Ensembl - ENSG00000124493
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grm4ENSDARG00000040156Danio rerio
 GRM4ENSGALG00000002840Gallus gallus
 Grm4ENSMUSG00000063239Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRM8 / O00222 / glutamate metabotropic receptor 8ENSG0000017960375
GRM7 / Q14831 / glutamate metabotropic receptor 7ENSG0000019627769
GRM6 / O15303 / glutamate metabotropic receptor 6ENSG0000011326266
GRM2 / Q14416 / glutamate metabotropic receptor 2ENSG0000016408245
GRM3 / Q14832 / glutamate metabotropic receptor 3ENSG0000019882244
GRM5 / P41594 / glutamate metabotropic receptor 5ENSG0000016895942
GRM1 / Q13255 / glutamate metabotropic receptor 1ENSG0000015282240
GPRC6A / Q5T6X5 / G protein-coupled receptor class C group 6 member AENSG0000017361223
Q7RTX1 / TAS1R1 / taste 1 receptor member 1ENSG0000017366223
Q7RTX0 / TAS1R3 / taste 1 receptor member 3ENSG0000016996221
Q8TE23 / TAS1R2 / taste 1 receptor member 2ENSG0000017900221


Protein motifs (from Interpro)
Interpro ID Name
 IPR000162  GPCR, family 3, metabotropic glutamate receptor
 IPR000337  GPCR, family 3
 IPR001786  GPCR, family 3, metabotropic glutamate receptor 4
 IPR001828  Receptor, ligand binding region
 IPR011500  GPCR, family 3, nine cysteines domain
 IPR017978  GPCR family 3, C-terminal
 IPR017979  GPCR, family 3, conserved site
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway IMP
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007269 neurotransmitter secretion TAS
 biological_processGO:0043410 positive regulation of MAPK cascade IEP
 biological_processGO:0043523 regulation of neuron apoptotic process TAS
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IBA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0042734 presynaptic membrane IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0008066 glutamate receptor activity IMP


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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