ENSG00000164082


Homo sapiens

Features
Gene ID: ENSG00000164082
  
Biological name :GRM2
  
Synonyms : glutamate metabotropic receptor 2 / GRM2 / Q14416
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p21.2
Gene start: 51707070
Gene end: 51718613
  
Corresponding Affymetrix probe sets: 208465_at (Human Genome U133 Plus 2.0 Array)   241802_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000404797
Ensembl peptide - ENSP00000408906
Ensembl peptide - ENSP00000296479
Ensembl peptide - ENSP00000378492
NCBI entrez gene - 2912     See in Manteia.
OMIM - 604099
RefSeq - XM_017006271
RefSeq - XM_011533641
RefSeq - XM_011533644
RefSeq - XM_011533645
RefSeq - XM_011533646
RefSeq - XM_011533647
RefSeq - NM_000839
RefSeq - NM_001130063
RefSeq - XM_011533635
RefSeq - XM_011533636
RefSeq - XM_011533637
RefSeq - XM_011533638
RefSeq - XM_011533639
RefSeq - XM_011533640
RefSeq Peptide - NP_000830
swissprot - C9JL63
swissprot - H7BXL3
swissprot - Q14416
swissprot - C9JD41
Ensembl - ENSG00000164082
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grm2aENSDARG00000004150Danio rerio
 grm2bENSDARG00000007195Danio rerio
 GRM2ENSGALG00000003839Gallus gallus
 Grm2ENSMUSG00000023192Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRM3 / Q14832 / glutamate metabotropic receptor 3ENSG0000019882268
GRM4 / Q14833 / glutamate metabotropic receptor 4ENSG0000012449347
GRM6 / O15303 / glutamate metabotropic receptor 6ENSG0000011326245
GRM7 / Q14831 / glutamate metabotropic receptor 7ENSG0000019627745
GRM8 / O00222 / glutamate metabotropic receptor 8ENSG0000017960345
GRM1 / Q13255 / glutamate metabotropic receptor 1ENSG0000015282244
GRM5 / P41594 / glutamate metabotropic receptor 5ENSG0000016895944
GPRC6A / Q5T6X5 / G protein-coupled receptor class C group 6 member AENSG0000017361225
Q8TE23 / TAS1R2 / taste 1 receptor member 2ENSG0000017900224
Q7RTX1 / TAS1R1 / taste 1 receptor member 1ENSG0000017366224
Q7RTX0 / TAS1R3 / taste 1 receptor member 3ENSG0000016996224


Protein motifs (from Interpro)
Interpro ID Name
 IPR000162  GPCR, family 3, metabotropic glutamate receptor
 IPR000337  GPCR, family 3
 IPR001458  GPCR, family 3, metabotropic glutamate receptor 2
 IPR001828  Receptor, ligand binding region
 IPR011500  GPCR, family 3, nine cysteines domain
 IPR017978  GPCR family 3, C-terminal
 IPR017979  GPCR, family 3, conserved site
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007194 negative regulation of adenylate cyclase activity TAS
 biological_processGO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway IEA
 biological_processGO:0007216 G-protein coupled glutamate receptor signaling pathway IBA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0014047 glutamate secretion IEA
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0001641 group II metabotropic glutamate receptor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005246 calcium channel regulator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008066 glutamate receptor activity TAS


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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