ENSG00000155511


Homo sapiens

Features
Gene ID: ENSG00000155511
  
Biological name :GRIA1
  
Synonyms : glutamate ionotropic receptor AMPA type subunit 1 / GRIA1 / P42261
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q33.2
Gene start: 153489615
Gene end: 153813869
  
Corresponding Affymetrix probe sets: 209793_at (Human Genome U133 Plus 2.0 Array)   211520_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428994
Ensembl peptide - ENSP00000285900
Ensembl peptide - ENSP00000339343
Ensembl peptide - ENSP00000415569
Ensembl peptide - ENSP00000427864
Ensembl peptide - ENSP00000427920
NCBI entrez gene - 2890     See in Manteia.
OMIM - 138248
RefSeq - XM_017009393
RefSeq - NM_000827
RefSeq - NM_001114183
RefSeq - NM_001258019
RefSeq - NM_001258020
RefSeq - NM_001258021
RefSeq - NM_001258022
RefSeq - NM_001258023
RefSeq - XM_011537635
RefSeq - XM_017009392
RefSeq Peptide - NP_001244949
RefSeq Peptide - NP_001244950
RefSeq Peptide - NP_001244951
RefSeq Peptide - NP_001244952
RefSeq Peptide - NP_001244948
RefSeq Peptide - NP_000818
RefSeq Peptide - NP_001107655
swissprot - P42261
Ensembl - ENSG00000155511
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gria1aENSDARG00000021352Danio rerio
 gria1bENSDARG00000032714Danio rerio
 GRIA1ENSGALG00000004083Gallus gallus
 Gria1ENSMUSG00000020524Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRIA4 / P48058 / glutamate ionotropic receptor AMPA type subunit 4ENSG0000015257865
GRIA2 / P42262 / glutamate ionotropic receptor AMPA type subunit 2ENSG0000012025165
GRIA3 / P42263 / glutamate ionotropic receptor AMPA type subunit 3ENSG0000012567565
GRIK1 / P39086 / glutamate ionotropic receptor kainate type subunit 1ENSG0000017118937
GRIK2 / Q13002 / glutamate ionotropic receptor kainate type subunit 2ENSG0000016441837
GRIK3 / Q13003 / glutamate ionotropic receptor kainate type subunit 3ENSG0000016387336
GRIK4 / Q16099 / glutamate ionotropic receptor kainate type subunit 4ENSG0000014940334
GRIK5 / Q16478 / glutamate ionotropic receptor kainate type subunit 5ENSG0000010573733
GRID1 / Q9ULK0 / glutamate ionotropic receptor delta type subunit 1ENSG0000018277126
GRID2 / O43424 / glutamate ionotropic receptor delta type subunit 2ENSG0000015220824
GRIN2C / Q14957 / glutamate ionotropic receptor NMDA type subunit 2CENSG0000016150922
GRIN2D / O15399 / glutamate ionotropic receptor NMDA type subunit 2DENSG0000010546421
GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2BENSG0000027307921
GRIN2A / Q12879 / glutamate ionotropic receptor NMDA type subunit 2AENSG0000018345420
GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1ENSG0000017688419
GRIN3A / Q8TCU5 / glutamate ionotropic receptor NMDA type subunit 3AENSG0000019878518
GRIN3B / O60391 / glutamate ionotropic receptor NMDA type subunit 3BENSG0000011603218


Protein motifs (from Interpro)
Interpro ID Name
 IPR001320  Ionotropic glutamate receptor
 IPR001508  Ionotropic glutamate receptor, metazoa
 IPR001828  Receptor, ligand binding region
 IPR019594  Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0007616 long-term memory IEA
 biological_processGO:0031623 receptor internalization IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IEA
 biological_processGO:0048208 COPII vesicle coating TAS
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060292 long term synaptic depression IEA
 biological_processGO:0099566 regulation of postsynaptic cytosolic calcium ion concentration IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0008328 ionotropic glutamate receptor complex IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane TAS
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0032281 AMPA glutamate receptor complex IEA
 cellular_componentGO:0032590 dendrite membrane IEA
 cellular_componentGO:0032591 dendritic spine membrane IDA
 cellular_componentGO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane TAS
 cellular_componentGO:0036477 somatodendritic compartment IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine ISS
 cellular_componentGO:0044308 axonal spine IEA
 cellular_componentGO:0044309 neuron spine IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0055037 recycling endosome IDA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 cellular_componentGO:0098794 postsynapse IEA
 cellular_componentGO:0098839 postsynaptic density membrane IEA
 molecular_functionGO:0001540 amyloid-beta binding ISS
 molecular_functionGO:0004970 ionotropic glutamate receptor activity IEA
 molecular_functionGO:0004971 AMPA glutamate receptor activity IDA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005231 excitatory extracellular ligand-gated ion channel activity TAS
 molecular_functionGO:0005234 extracellularly glutamate-gated ion channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008066 glutamate receptor activity TAS
 molecular_functionGO:0030165 PDZ domain binding ISS
 molecular_functionGO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration IEA
 molecular_functionGO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IEA


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
Activation of AMPA receptors
Trafficking of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation
Cargo concentration in the ER
Synaptic adhesion-like molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000120251 GRIA2 / P42262 / glutamate ionotropic receptor AMPA type subunit 2  / reaction / complex
 ENSG00000082458 DLG3 / Q92796 / discs large MAGUK scaffold protein 3  / reaction
 ENSG00000125675 GRIA3 / P42263 / glutamate ionotropic receptor AMPA type subunit 3  / reaction / complex
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / reaction
 ENSG00000152578 GRIA4 / P48058 / glutamate ionotropic receptor AMPA type subunit 4  / complex / reaction
 ENSG00000161203 AP2M1 / Q96CW1 / adaptor related protein complex 2 mu 1 subunit  / reaction
 ENSG00000277586 NEFL / P07196 / neurofilament light  / reaction
 ENSG00000006125 AP2B1 / P63010 / adaptor related protein complex 2 beta 1 subunit  / reaction
 ENSG00000145349 CAMK2D / Q13557 / calcium/calmodulin dependent protein kinase II delta  / reaction
 ENSG00000100151 PICK1 / Q9NRD5 / protein interacting with PRKCA 1  / reaction
 ENSG00000077522 ACTN2 / P35609 / actinin alpha 2  / reaction
 ENSG00000075711 DLG1 / Q12959 / discs large MAGUK scaffold protein 1  / reaction
 ENSG00000183020 AP2A2 / O94973 / adaptor related protein complex 2 alpha 2 subunit  / reaction
 ENSG00000150672 DLG2 / Q15700 / discs large MAGUK scaffold protein 2  / reaction
 ENSG00000127914 AKAP9 / Q99996 / A-kinase anchoring protein 9  / reaction
 ENSG00000155974 GRIP1 / Q9Y3R0 / glutamate receptor interacting protein 1  / reaction
 ENSG00000148660 CAMK2G / Q13555 / calcium/calmodulin dependent protein kinase II gamma  / reaction
 ENSG00000105464 GRIN2D / O15399 / glutamate ionotropic receptor NMDA type subunit 2D  / reaction
 ENSG00000033122 LRRC7 / Q96NW7 / leucine rich repeat containing 7  / reaction
 ENSG00000161509 GRIN2C / Q14957 / glutamate ionotropic receptor NMDA type subunit 2C  / reaction
 ENSG00000183454 GRIN2A / Q12879 / glutamate ionotropic receptor NMDA type subunit 2A  / reaction
 ENSG00000155511 GRIA1 / P42261 / glutamate ionotropic receptor AMPA type subunit 1  / complex / reaction
 ENSG00000143786 CNIH3 / Q8TBE1 / cornichon family AMPA receptor auxiliary protein 3  / complex / reaction
 ENSG00000176884 GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1  / reaction
 ENSG00000070808 CAMK2A / Q9UQM7 / calcium/calmodulin dependent protein kinase II alpha  / reaction
 ENSG00000174871 CNIH2 / Q6PI25 / cornichon family AMPA receptor auxiliary protein 2  / complex / reaction
 ENSG00000058404 CAMK2B / Q13554 / calcium/calmodulin dependent protein kinase II beta  / reaction
 ENSG00000273079 GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2B  / reaction
 ENSG00000128011 LRFN1 / Q9P244 / leucine rich repeat and fibronectin type III domain containing 1  / complex / reaction
 ENSG00000042753 AP2S1 / P53680 / adaptor related protein complex 2 sigma 1 subunit  / reaction
 ENSG00000196961 AP2A1 / O95782 / adaptor related protein complex 2 alpha 1 subunit  / reaction






 

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