ENSG00000183020


Homo sapiens

Features
Gene ID: ENSG00000183020
  
Biological name :AP2A2
  
Synonyms : adaptor related protein complex 2 alpha 2 subunit / AP2A2 / O94973
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p15.5
Gene start: 924894
Gene end: 1012245
  
Corresponding Affymetrix probe sets: 211779_x_at (Human Genome U133 Plus 2.0 Array)   212159_x_at (Human Genome U133 Plus 2.0 Array)   212161_at (Human Genome U133 Plus 2.0 Array)   215764_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433498
Ensembl peptide - ENSP00000437228
Ensembl peptide - ENSP00000436059
Ensembl peptide - ENSP00000435863
Ensembl peptide - ENSP00000435756
Ensembl peptide - ENSP00000434563
Ensembl peptide - ENSP00000434553
Ensembl peptide - ENSP00000434432
Ensembl peptide - ENSP00000327694
Ensembl peptide - ENSP00000413234
Ensembl peptide - ENSP00000431630
NCBI entrez gene - 161     See in Manteia.
OMIM - 607242
RefSeq - XM_011519929
RefSeq - XM_011519930
RefSeq - NM_012305
RefSeq - NM_001242837
RefSeq Peptide - NP_036437
RefSeq Peptide - NP_001229766
swissprot - E9PS94
swissprot - O94973
swissprot - H0YEG0
swissprot - E9PR62
swissprot - E9PQP4
swissprot - E9PPZ3
swissprot - E9PPY8
swissprot - E9PNC4
swissprot - H0YDE9
Ensembl - ENSG00000183020
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ap2a1ENSDARG00000054320Danio rerio
 AP2A2ENSGALG00000006799Gallus gallus
 Ap2a2ENSMUSG00000002957Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AP2A1 / O95782 / adaptor related protein complex 2 alpha 1 subunitENSG0000019696182


Protein motifs (from Interpro)
Interpro ID Name
 IPR002553  Clathrin/coatomer adaptor, adaptin-like, N-terminal
 IPR003164  Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain
 IPR008152  Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
 IPR009028  Coatomer/calthrin adaptor appendage, C-terminal subdomain
 IPR011989  Armadillo-like helical
 IPR013041  Clathrin adaptor, appendage, Ig-like subdomain superfamily
 IPR016024  Armadillo-type fold
 IPR017104  Adaptor protein complex AP-2, alpha subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007018 microtubule-based movement TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0032802 low-density lipoprotein particle receptor catabolic process TAS
 biological_processGO:0034383 low-density lipoprotein particle clearance TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:0050690 regulation of defense response to virus by virus TAS
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway TAS
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0072583 clathrin-dependent endocytosis TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030117 membrane coat IEA
 cellular_componentGO:0030122 AP-2 adaptor complex TAS
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0030669 clathrin-coated endocytic vesicle membrane TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0036020 endolysosome membrane TAS
 cellular_componentGO:0045334 clathrin-coated endocytic vesicle NAS
 cellular_componentGO:0101003 ficolin-1-rich granule membrane TAS
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0035615 clathrin adaptor activity TAS
 molecular_functionGO:0097718 disordered domain specific binding IEA


Pathways (from Reactome)
Pathway description
Nef Mediated CD4 Down-regulation
Retrograde neurotrophin signalling
Nef Mediated CD8 Down-regulation
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Neutrophil degranulation
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000004975 DVL2 / O14641 / dishevelled segment polarity protein 2  / complex / reaction
 ENSG00000010610 CD4 / P01730 / CD4 molecule  / reaction / complex
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / complex / reaction
 ENSG00000100246 DNAL4 / O96015 / dynein axonemal light chain 4  / reaction
 ENSG00000122705 CLTA / P09496 / clathrin light chain A  / complex / reaction
 ENSG00000114251 WNT5A / P41221 / Wnt family member 5A  / reaction / complex
 ENSG00000042753 AP2S1 / P53680 / adaptor related protein complex 2 sigma 1 subunit  / complex / reaction
 ENSG00000120251 GRIA2 / P42262 / glutamate ionotropic receptor AMPA type subunit 2  / reaction
 ENSG00000175416 CLTB / P09497 / clathrin light chain B  / complex / reaction
 ENSG00000155511 GRIA1 / P42261 / glutamate ionotropic receptor AMPA type subunit 1  / reaction
 ENSG00000152578 GRIA4 / P48058 / glutamate ionotropic receptor AMPA type subunit 4  / reaction
 ENSG00000161203 AP2M1 / Q96CW1 / adaptor related protein complex 2 mu 1 subunit  / reaction / complex
 ENSG00000141480 ARRB2 / P32121 / arrestin beta 2  / reaction / complex
 ENSG00000141367 CLTC / Q00610 / clathrin heavy chain  / complex / reaction
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / reaction / complex
 ENSG00000130164 LDLR / P01130 / low density lipoprotein receptor  / reaction / complex
 ENSG00000198910 L1CAM / P32004 / L1 cell adhesion molecule  / complex / reaction
 ENSG00000107295 Q99962 / SH3GL2 / SH3 domain containing GRB2 like 2, endophilin A1  / complex / reaction
 ENSG00000006125 AP2B1 / P63010 / adaptor related protein complex 2 beta 1 subunit  / complex / reaction
 ENSG00000183020 AP2A2 / O94973 / adaptor related protein complex 2 alpha 2 subunit  / reaction / complex
 ENSG00000100151 PICK1 / Q9NRD5 / protein interacting with PRKCA 1  / reaction
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / complex / reaction
 ENSG00000147852 VLDLR / P98155 / very low density lipoprotein receptor  / complex / reaction
 ENSG00000155974 GRIP1 / Q9Y3R0 / glutamate receptor interacting protein 1  / reaction
 ENSG00000019582 CD74 / P04233 / CD74 molecule  / complex / reaction
 ENSG00000169174 PCSK9 / Q8NBP7 / proprotein convertase subtilisin/kexin type 9  / complex / reaction
 ENSG00000092964 DPYSL2 / Q16555 / dihydropyrimidinase like 2  / complex
 ENSG00000125675 GRIA3 / P42263 / glutamate ionotropic receptor AMPA type subunit 3  / reaction
 ENSG00000198400 NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1  / reaction / complex
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / complex / reaction
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / complex / reaction
 ENSG00000196961 AP2A1 / O95782 / adaptor related protein complex 2 alpha 1 subunit  / complex / reaction
 ENSG00000134259 NGF / P01138 / nerve growth factor  / complex / reaction
 ENSG00000133961 NUMB / P49757 / NUMB, endocytic adaptor protein  / complex
 ENSG00000172116 CD8B / P10966 / CD8b molecule  / complex / reaction
 ENSG00000047249 Q9UI12 / ATP6V1H / ATPase H+ transporting V1 subunit H  / complex / reaction
 ENSG00000090889 KIF4A / O95239 / kinesin family member 4A  / complex / reaction
 ENSG00000070371 CLTCL1 / P53675 / clathrin heavy chain like 1  / complex / reaction
 ENSG00000226650 KIF4B / Q2VIQ3 / kinesin family member 4B  / complex / reaction
 ENSG00000174804 FZD4 / Q9ULV1 / frizzled class receptor 4  / complex / reaction






 

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