ENSG00000175416


Homo sapiens

Features
Gene ID: ENSG00000175416
  
Biological name :CLTB
  
Synonyms : clathrin light chain B / CLTB / P09497
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q35.2
Gene start: 176392455
Gene end: 176416569
  
Corresponding Affymetrix probe sets: 205172_x_at (Human Genome U133 Plus 2.0 Array)   206284_x_at (Human Genome U133 Plus 2.0 Array)   211043_s_at (Human Genome U133 Plus 2.0 Array)   216934_at (Human Genome U133 Plus 2.0 Array)   221996_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000310812
Ensembl peptide - ENSP00000427229
Ensembl peptide - ENSP00000424739
Ensembl peptide - ENSP00000422978
Ensembl peptide - ENSP00000309415
NCBI entrez gene - 1212     See in Manteia.
OMIM - 118970
RefSeq - XM_017009027
RefSeq - NM_001834
RefSeq - NM_007097
RefSeq - XM_017009026
RefSeq Peptide - NP_009028
RefSeq Peptide - NP_001825
swissprot - H0Y9Q6
swissprot - P09497
swissprot - B4DTF9
swissprot - A0A024R7S3
swissprot - D6RJD1
Ensembl - ENSG00000175416
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cltbENSDARG00000052368Danio rerio
 CLTBENSGALG00000003344Gallus gallus
 CltbENSMUSG00000047547Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CLTA / P09496 / clathrin light chain AENSG0000012270559


Protein motifs (from Interpro)
Interpro ID Name
 IPR000996  Clathrin light chain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0072583 clathrin-dependent endocytosis IBA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030118 clathrin coat NAS
 cellular_componentGO:0030125 clathrin vesicle coat IBA
 cellular_componentGO:0030130 clathrin coat of trans-Golgi network vesicle IEA
 cellular_componentGO:0030132 clathrin coat of coated pit IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0045334 clathrin-coated endocytic vesicle NAS
 cellular_componentGO:0060170 ciliary membrane IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0032050 clathrin heavy chain binding IBA
 molecular_functionGO:0042277 peptide binding IEA


Pathways (from Reactome)
Pathway description
Gap junction degradation
Formation of annular gap junctions
EPH-ephrin mediated repulsion of cells
Lysosome Vesicle Biogenesis
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000109971 HSPA8 / P11142 / heat shock protein family A (Hsp70) member 8  / complex
 ENSG00000161203 AP2M1 / Q96CW1 / adaptor related protein complex 2 mu 1 subunit  / complex / reaction
 ENSG00000006125 AP2B1 / P63010 / adaptor related protein complex 2 beta 1 subunit  / reaction / complex
 ENSG00000122705 CLTA / P09496 / clathrin light chain A  / complex
 ENSG00000183020 AP2A2 / O94973 / adaptor related protein complex 2 alpha 2 subunit  / complex / reaction
 ENSG00000042753 AP2S1 / P53680 / adaptor related protein complex 2 sigma 1 subunit  / complex / reaction
 ENSG00000175416 CLTB / P09497 / clathrin light chain B  / complex
 ENSG00000196961 AP2A1 / O95782 / adaptor related protein complex 2 alpha 1 subunit  / reaction / complex
 ENSG00000141367 CLTC / Q00610 / clathrin heavy chain  / complex
 ENSG00000070371 CLTCL1 / P53675 / clathrin heavy chain like 1  / complex






 

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