Manteia

ENSG00000141367

Homo sapiens

Features

Gene ID:	ENSG00000141367

Biological name :	CLTC

Synonyms :	clathrin heavy chain / CLTC / Q00610

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	17
Strand:	1
Band:	q23.1
Gene start:	59619689
Gene end:	59696956

Corresponding Affymetrix probe sets:	200614_at (Human Genome U133 Plus 2.0 Array) 210498_at (Human Genome U133 Plus 2.0 Array) 239871_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000465200 Ensembl peptide - ENSP00000463336 Ensembl peptide - ENSP00000479606 Ensembl peptide - ENSP00000269122 Ensembl peptide - ENSP00000376763 Ensembl peptide - ENSP00000461977 Ensembl peptide - ENSP00000462252 Ensembl peptide - ENSP00000462592 Ensembl peptide - ENSP00000463068 NCBI entrez gene - 1213 See in Manteia. OMIM - 118955 RefSeq - XM_005257012 RefSeq - NM_001288653 RefSeq - NM_004859 RefSeq Peptide - NP_001275582 RefSeq Peptide - NP_004850 swissprot - J3QL20 swissprot - K7EJJ5 swissprot - Q00610 swissprot - A0A087WVQ6 swissprot - J3KRF5 swissprot - J3KSQ2 swissprot - J3KS13 swissprot - J3KTN1 Ensembl - ENSG00000141367

Related genetic diseases (OMIM):	617854 - Mental retardation, autosomal dominant 56, 617854

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
cltcb	ENSDARG00000090716	Danio rerio
CLTC	ENSGALG00000005139	Gallus gallus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
CLTCL1 / P53675 / clathrin heavy chain like 1	ENSG00000070371	82

Protein motifs (from Interpro)

Interpro ID	Name
IPR000547	Clathrin, heavy chain/VPS, 7-fold repeat
IPR011990	Tetratricopeptide-like helical domain superfamily
IPR012331	Clathrin, heavy chain, linker
IPR015348	Clathrin, heavy chain, linker, core motif
IPR016024	Armadillo-type fold
IPR016341	Clathrin, heavy chain
IPR022365	Clathrin, heavy chain, propeller repeat

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000278	mitotic cell cycle	IMP
biological_process	GO:0001649	osteoblast differentiation	HDA
biological_process	GO:0006886	intracellular protein transport	IEA
biological_process	GO:0006898	receptor-mediated endocytosis	IMP
biological_process	GO:0006914	autophagy	IEA
biological_process	GO:0007018	microtubule-based movement	TAS
biological_process	GO:0007049	cell cycle	IEA
biological_process	GO:0016192	vesicle-mediated transport	IEA
biological_process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	TAS
biological_process	GO:0031623	receptor internalization	IMP
biological_process	GO:0032802	low-density lipoprotein particle receptor catabolic process	TAS
biological_process	GO:0033572	transferrin transport	IMP
biological_process	GO:0034383	low-density lipoprotein particle clearance	TAS
biological_process	GO:0042147	retrograde transport, endosome to Golgi	IMP
biological_process	GO:0045056	transcytosis	IMP
biological_process	GO:0048268	clathrin coat assembly	IEA
biological_process	GO:0051301	cell division	IEA
biological_process	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	TAS
biological_process	GO:0060236	regulation of mitotic spindle organization	IMP
biological_process	GO:0061024	membrane organization	TAS
biological_process	GO:0072583	clathrin-dependent endocytosis	IMP
biological_process	GO:1900126	negative regulation of hyaluronan biosynthetic process	IMP
biological_process	GO:1903077	negative regulation of protein localization to plasma membrane	IMP
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005764	lysosome	IDA
cellular_component	GO:0005768	endosome	IDA
cellular_component	GO:0005819	spindle	IEA
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0005856	cytoskeleton	IEA
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0005905	clathrin-coated pit	IEA
cellular_component	GO:0005925	focal adhesion	HDA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0030118	clathrin coat	NAS
cellular_component	GO:0030130	clathrin coat of trans-Golgi network vesicle	IEA
cellular_component	GO:0030132	clathrin coat of coated pit	IEA
cellular_component	GO:0030136	clathrin-coated vesicle	IDA
cellular_component	GO:0030659	cytoplasmic vesicle membrane	IEA
cellular_component	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS
cellular_component	GO:0031410	cytoplasmic vesicle	IEA
cellular_component	GO:0032588	trans-Golgi network membrane	TAS
cellular_component	GO:0032991	protein-containing complex	IDA
cellular_component	GO:0036020	endolysosome membrane	TAS
cellular_component	GO:0042470	melanosome	IEA
cellular_component	GO:0043231	intracellular membrane-bounded organelle	IDA
cellular_component	GO:0045334	clathrin-coated endocytic vesicle	NAS
cellular_component	GO:0070062	extracellular exosome	HDA
cellular_component	GO:0071439	clathrin complex	IEA
cellular_component	GO:0072686	mitotic spindle	IDA
cellular_component	GO:1903561	extracellular vesicle	HDA
cellular_component	GO:1990498	mitotic spindle microtubule	IDA
molecular_function	GO:0003723	RNA binding	HDA
molecular_function	GO:0003725	double-stranded RNA binding	IDA
molecular_function	GO:0005198	structural molecule activity	IEA
molecular_function	GO:0005488	binding	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0019901	protein kinase binding	ISS
molecular_function	GO:0032051	clathrin light chain binding	IEA
molecular_function	GO:0050750	low-density lipoprotein particle receptor binding	IPI
molecular_function	GO:0097718	disordered domain specific binding	IPI
molecular_function	GO:1990381	ubiquitin-specific protease binding	IPI

Pathways (from Reactome)

Pathway description

Entry of Influenza Virion into Host Cell via Endocytosis

Retrograde neurotrophin signalling

Gap junction degradation

Formation of annular gap junctions

MHC class II antigen presentation

EPH-ephrin mediated repulsion of cells

Lysosome Vesicle Biogenesis

Recycling pathway of L1

WNT5A-dependent internalization of FZD4

WNT5A-dependent internalization of FZD2, FZD5 and ROR2

Cargo recognition for clathrin-mediated endocytosis

Clathrin-mediated endocytosis

VLDLR internalisation and degradation

LDL clearance

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000004975	DVL2 / O14641 / dishevelled segment polarity protein 2	/ reaction / complex
ENSG00000100030	MAPK1 / P28482 / mitogen-activated protein kinase 1	/ complex / reaction
ENSG00000100246	DNAL4 / O96015 / dynein axonemal light chain 4	/ reaction
ENSG00000109971	HSPA8 / P11142 / heat shock protein family A (Hsp70) member 8	/ complex
ENSG00000122705	CLTA / P09496 / clathrin light chain A	/ complex / reaction
ENSG00000129354	AP1M2 / Q9Y6Q5 / adaptor related protein complex 1 mu 2 subunit	/ complex
ENSG00000114251	WNT5A / P41221 / Wnt family member 5A	/ complex / reaction
ENSG00000042753	AP2S1 / P53680 / adaptor related protein complex 2 sigma 1 subunit	/ complex / reaction
ENSG00000072958	AP1M1 / Q9BXS5 / adaptor related protein complex 1 mu 1 subunit	/ complex
ENSG00000146352	CLVS2 / Q5SYC1 / clavesin 2	/ complex
ENSG00000161203	AP2M1 / Q96CW1 / adaptor related protein complex 2 mu 1 subunit	/ complex / reaction
ENSG00000141480	ARRB2 / P32121 / arrestin beta 2	/ reaction / complex
ENSG00000130164	LDLR / P01130 / low density lipoprotein receptor	/ reaction / complex
ENSG00000183020	AP2A2 / O94973 / adaptor related protein complex 2 alpha 2 subunit	/ complex / reaction
ENSG00000141367	CLTC / Q00610 / clathrin heavy chain	/ complex / reaction
ENSG00000107295	Q99962 / SH3GL2 / SH3 domain containing GRB2 like 2, endophilin A1	/ complex / reaction
ENSG00000198910	L1CAM / P32004 / L1 cell adhesion molecule	/ reaction / complex
ENSG00000006125	AP2B1 / P63010 / adaptor related protein complex 2 beta 1 subunit	/ reaction / complex
ENSG00000237541	P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2	/ complex / reaction
ENSG00000147852	VLDLR / P98155 / very low density lipoprotein receptor	/ reaction / complex
ENSG00000204287	P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha	/ reaction / complex
ENSG00000070371	CLTCL1 / P53675 / clathrin heavy chain like 1	/ complex
ENSG00000231389	P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1	/ reaction / complex
ENSG00000198400	NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1	/ complex / reaction
ENSG00000196735	P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1	/ reaction / complex
ENSG00000196961	AP2A1 / O95782 / adaptor related protein complex 2 alpha 1 subunit	/ reaction / complex
ENSG00000134259	NGF / P01138 / nerve growth factor	/ reaction / complex
ENSG00000079805	DNM2 / P50570 / dynamin 2	/ complex / reaction
ENSG00000019582	CD74 / P04233 / CD74 molecule	/ reaction / complex
ENSG00000169174	PCSK9 / Q8NBP7 / proprotein convertase subtilisin/kexin type 9	/ reaction / complex
ENSG00000175416	CLTB / P09497 / clathrin light chain B	/ complex
ENSG00000166747	AP1G1 / O43747 / adaptor related protein complex 1 gamma 1 subunit	/ complex
ENSG00000152056	AP1S3 / Q96PC3 / adaptor related protein complex 1 sigma 3 subunit	/ complex
ENSG00000182287	AP1S2 / P56377 / adaptor related protein complex 1 sigma 2 subunit	/ complex
ENSG00000100280	AP1B1 / Q10567 / adaptor related protein complex 1 beta 1 subunit	/ complex
ENSG00000177182	CLVS1 / Q8IUQ0 / clavesin 1	/ complex
ENSG00000106367	AP1S1 / P61966 / adaptor related protein complex 1 sigma 1 subunit	/ complex
ENSG00000090889	KIF4A / O95239 / kinesin family member 4A	/ complex / reaction
ENSG00000226650	KIF4B / Q2VIQ3 / kinesin family member 4B	/ complex / reaction
ENSG00000174804	FZD4 / Q9ULV1 / frizzled class receptor 4	/ reaction / complex

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr