Homo sapiens

Gene ID: ENSG00000226650
Biological name :KIF4B
Synonyms : KIF4B / kinesin family member 4B / Q2VIQ3
Possible biological names infered from orthology :
Species: Homo sapiens
Chr. number: 5
Strand: 1
Band: q33.2
Gene start: 155013755
Gene end: 155018132
Corresponding Affymetrix probe sets:
Cross references: Ensembl peptide - ENSP00000387875
NCBI entrez gene - 285643     See in Manteia.
OMIM - 609184
RefSeq - NM_001099293
RefSeq Peptide - NP_001092763
swissprot - Q2VIQ3
Ensembl - ENSG00000226650
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kif4ENSDARG00000005462Danio rerio
 KIF4AENSGALG00000004195Gallus gallus
 Kif4ENSMUSG00000034311Mus musculus

Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KIF4A / O95239 / kinesin family member 4AENSG0000009088994
KIF21A / Q7Z4S6 / kinesin family member 21AENSG0000013911628
KIF21B / O75037 / kinesin family member 21BENSG0000011685228
KIF27 / Q86VH2 / kinesin family member 27ENSG0000016511524
KIF7 / Q2M1P5 / kinesin family member 7ENSG0000016681323
CENPE / Q02224 / centromere protein EENSG0000013877823
KIF15 / Q9NS87 / kinesin family member 15ENSG0000016380821
KIF17 / Q9P2E2 / kinesin family member 17ENSG0000011724520
KIF5C / O60282 / kinesin family member 5CENSG0000016828019
KIF11 / P52732 / kinesin family member 11ENSG0000013816019
KIF5B / P33176 / kinesin family member 5BENSG0000017075919
KIF5A / Q12840 / kinesin family member 5AENSG0000015598019
KIF3A / Q9Y496 / kinesin family member 3AENSG0000013143718
KIF3B / O15066 / kinesin family member 3BENSG0000010135017
KIF3C / O14782 / kinesin family member 3CENSG0000008473116

Protein motifs (from Interpro)
Interpro ID Name
 IPR001752  Kinesin motor domain
 IPR019821  Kinesin motor domain, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027640  Kinesin-like protein
 IPR033467  Tesmin/TSO1-like CXC domain
 IPR036961  Kinesin motor domain superfamily

Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis IMP
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS
 biological_processGO:0007018 microtubule-based movement TAS
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0051256 mitotic spindle midzone assembly IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005871 kinesin complex IBA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0045171 intercellular bridge IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IBA

Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
Recycling pathway of L1
COPI-dependent Golgi-to-ER retrograde traffic

Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match

Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000183020 AP2A2 / O94973 / adaptor related protein complex 2 alpha 2 subunit  / reaction / complex
 ENSG00000122705 CLTA / P09496 / clathrin light chain A  / complex / reaction
 ENSG00000141367 CLTC / Q00610 / clathrin heavy chain  / reaction / complex
 ENSG00000090889 KIF4A / O95239 / kinesin family member 4A  / complex / reaction
 ENSG00000107295 Q99962 / SH3GL2 / SH3 domain containing GRB2 like 2, endophilin A1  / reaction / complex
 ENSG00000198910 L1CAM / P32004 / L1 cell adhesion molecule  / complex / reaction
 ENSG00000006125 AP2B1 / P63010 / adaptor related protein complex 2 beta 1 subunit  / complex / reaction
 ENSG00000226650 KIF4B / Q2VIQ3 / kinesin family member 4B  / reaction / complex
 ENSG00000161203 AP2M1 / Q96CW1 / adaptor related protein complex 2 mu 1 subunit  / reaction / complex
 ENSG00000079616 KIF22 / Q14807 / kinesin family member 22  / reaction
 ENSG00000196961 AP2A1 / O95782 / adaptor related protein complex 2 alpha 1 subunit  / complex / reaction
 ENSG00000042753 AP2S1 / P53680 / adaptor related protein complex 2 sigma 1 subunit  / reaction / complex


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