ENSG00000170759


Homo sapiens

Features
Gene ID: ENSG00000170759
  
Biological name :KIF5B
  
Synonyms : KIF5B / kinesin family member 5B / P33176
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: p11.22
Gene start: 32009010
Gene end: 32056431
  
Corresponding Affymetrix probe sets: 201991_s_at (Human Genome U133 Plus 2.0 Array)   201992_s_at (Human Genome U133 Plus 2.0 Array)   224662_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000307078
NCBI entrez gene - 3799     See in Manteia.
OMIM - 602809
RefSeq - XM_017016224
RefSeq - NM_004521
RefSeq Peptide - NP_004512
swissprot - P33176
swissprot - V9HW29
Ensembl - ENSG00000170759
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kif5baENSDARG00000103394Danio rerio
 kif5baENSDARG00000074131Danio rerio
 KIF5BENSGALG00000007215Gallus gallus
 Kif5bENSMUSG00000006740Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KIF5C / O60282 / kinesin family member 5CENSG0000016828075
KIF5A / Q12840 / kinesin family member 5AENSG0000015598071
KIF21A / Q7Z4S6 / kinesin family member 21AENSG0000013911626
KIF4B / Q2VIQ3 / kinesin family member 4BENSG0000022665025
KIF4A / O95239 / kinesin family member 4AENSG0000009088925
CENPE / Q02224 / centromere protein EENSG0000013877825
KIF15 / Q9NS87 / kinesin family member 15ENSG0000016380824
KIF27 / Q86VH2 / kinesin family member 27ENSG0000016511524
KIF21B / O75037 / kinesin family member 21BENSG0000011685224
KIF7 / Q2M1P5 / kinesin family member 7ENSG0000016681324
KIF17 / Q9P2E2 / kinesin family member 17ENSG0000011724523
KIF11 / P52732 / kinesin family member 11ENSG0000013816023
KIF3A / Q9Y496 / kinesin family member 3AENSG0000013143721
KIF3B / O15066 / kinesin family member 3BENSG0000010135021
KIF3C / O14782 / kinesin family member 3CENSG0000008473121


Protein motifs (from Interpro)
Interpro ID Name
 IPR001752  Kinesin motor domain
 IPR019821  Kinesin motor domain, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027640  Kinesin-like protein
 IPR036961  Kinesin motor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement TAS
 biological_processGO:0007028 cytoplasm organization IEA
 biological_processGO:0007411 axon guidance IBA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0030705 cytoskeleton-dependent intracellular transport IBA
 biological_processGO:0031340 positive regulation of vesicle fusion IEA
 biological_processGO:0032230 positive regulation of synaptic transmission, GABAergic IEA
 biological_processGO:0035617 stress granule disassembly IEA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0042391 regulation of membrane potential IDA
 biological_processGO:0043268 positive regulation of potassium ion transport IDA
 biological_processGO:0047496 vesicle transport along microtubule IEA
 biological_processGO:0051642 centrosome localization IMP
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0072383 plus-end-directed vesicle transport along microtubule IEA
 biological_processGO:0090316 positive regulation of intracellular protein transport IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IDA
 biological_processGO:1905152 positive regulation of voltage-gated sodium channel activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005871 kinesin complex TAS
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0035253 ciliary rootlet IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043227 membrane-bounded organelle IEA
 cellular_componentGO:0044295 axonal growth cone IEA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding ISS
 molecular_functionGO:0008432 JUN kinase binding IEA
 molecular_functionGO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IBA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0099609 microtubule lateral binding IEA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
Insulin processing
RHO GTPases activate KTN1
COPI-dependent Golgi-to-ER retrograde traffic
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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