Homo sapiens

Gene ID: ENSG00000170759
Biological name :KIF5B
Synonyms : KIF5B / kinesin family member 5B / P33176
Possible biological names infered from orthology :
Species: Homo sapiens
Chr. number: 10
Strand: -1
Band: p11.22
Gene start: 32009010
Gene end: 32056431
Corresponding Affymetrix probe sets: 201991_s_at (Human Genome U133 Plus 2.0 Array)   201992_s_at (Human Genome U133 Plus 2.0 Array)   224662_at (Human Genome U133 Plus 2.0 Array)   
Cross references: Ensembl peptide - ENSP00000307078
NCBI entrez gene - 3799     See in Manteia.
OMIM - 602809
RefSeq - XM_017016224
RefSeq - NM_004521
RefSeq Peptide - NP_004512
swissprot - P33176
swissprot - V9HW29
Ensembl - ENSG00000170759
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kif5baENSDARG00000103394Danio rerio
 kif5baENSDARG00000074131Danio rerio
 KIF5BENSGALG00000007215Gallus gallus
 Kif5bENSMUSG00000006740Mus musculus

Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KIF5C / O60282 / kinesin family member 5CENSG0000016828075
KIF5A / Q12840 / kinesin family member 5AENSG0000015598071
KIF21A / Q7Z4S6 / kinesin family member 21AENSG0000013911626
KIF4B / Q2VIQ3 / kinesin family member 4BENSG0000022665025
KIF4A / O95239 / kinesin family member 4AENSG0000009088925
CENPE / Q02224 / centromere protein EENSG0000013877825
KIF15 / Q9NS87 / kinesin family member 15ENSG0000016380824
KIF27 / Q86VH2 / kinesin family member 27ENSG0000016511524
KIF21B / O75037 / kinesin family member 21BENSG0000011685224
KIF7 / Q2M1P5 / kinesin family member 7ENSG0000016681324
KIF17 / Q9P2E2 / kinesin family member 17ENSG0000011724523
KIF11 / P52732 / kinesin family member 11ENSG0000013816023
KIF3A / Q9Y496 / kinesin family member 3AENSG0000013143721
KIF3B / O15066 / kinesin family member 3BENSG0000010135021
KIF3C / O14782 / kinesin family member 3CENSG0000008473121

Protein motifs (from Interpro)
Interpro ID Name
 IPR001752  Kinesin motor domain
 IPR019821  Kinesin motor domain, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027640  Kinesin-like protein
 IPR036961  Kinesin motor domain superfamily

Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement TAS
 biological_processGO:0007028 cytoplasm organization IEA
 biological_processGO:0007411 axon guidance IBA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0030705 cytoskeleton-dependent intracellular transport IBA
 biological_processGO:0031340 positive regulation of vesicle fusion IEA
 biological_processGO:0032230 positive regulation of synaptic transmission, GABAergic IEA
 biological_processGO:0035617 stress granule disassembly IEA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0042391 regulation of membrane potential IDA
 biological_processGO:0043268 positive regulation of potassium ion transport IDA
 biological_processGO:0047496 vesicle transport along microtubule IEA
 biological_processGO:0051642 centrosome localization IMP
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0072383 plus-end-directed vesicle transport along microtubule IEA
 biological_processGO:0090316 positive regulation of intracellular protein transport IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IDA
 biological_processGO:1905152 positive regulation of voltage-gated sodium channel activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005871 kinesin complex TAS
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0035253 ciliary rootlet IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043227 membrane-bounded organelle IEA
 cellular_componentGO:0044295 axonal growth cone IEA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding ISS
 molecular_functionGO:0008432 JUN kinase binding IEA
 molecular_functionGO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IBA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0099609 microtubule lateral binding IEA

Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
Insulin processing
RHO GTPases activate KTN1
COPI-dependent Golgi-to-ER retrograde traffic

Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match

Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match


0 s.

External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


© Olivier Tassy / Olivier Pourquie 2007-2021
contact: otassy@igbmc.fr