ENSMUSG00000006740


Mus musculus

Features
Gene ID: ENSMUSG00000006740
  
Biological name :Kif5b
  
Synonyms : Kif5b / Kinesin-1 heavy chain / Q61768
  
Possible biological names infered from orthology : kinesin family member 5B / P33176
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: A1
Gene start: 6201002
Gene end: 6242174
  
Corresponding Affymetrix probe sets: 10457273 (MoGene1.0st)   1418427_at (Mouse Genome 430 2.0 Array)   1418428_at (Mouse Genome 430 2.0 Array)   1418429_at (Mouse Genome 430 2.0 Array)   1418430_at (Mouse Genome 430 2.0 Array)   1418431_at (Mouse Genome 430 2.0 Array)   1453524_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130750
Ensembl peptide - ENSMUSP00000025083
NCBI entrez gene - 16573     See in Manteia.
MGI - MGI:1098268
RefSeq - NM_008448
RefSeq Peptide - NP_032474
swissprot - E9QAK5
swissprot - Q61768
Ensembl - ENSMUSG00000006740
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kif5baENSDARG00000103394Danio rerio
 kif5baENSDARG00000074131Danio rerio
 KIF5BENSGALG00000007215Gallus gallus
 KIF5BENSG00000170759Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kif5c / P28738 / Kinesin heavy chain isoform 5C / O60282* / kinesin family member 5C*ENSMUSG0000002676474
Kif5a / P33175 / Kinesin heavy chain isoform 5A / Q12840* / kinesin family member 5A*ENSMUSG0000007465770
Kif21a / Q9QXL2 / Kinesin-like protein KIF21A / Q7Z4S6* / kinesin family member 21A*ENSMUSG0000002262926
Cenpe / centromere protein E / Q02224*ENSMUSG0000004532826
Kif7 / kinesin family member 7 / Q2M1P5*ENSMUSG0000005038224
Kif4 / P33174 / Chromosome-associated kinesin KIF4 / KIF4A* / KIF4B* / Q2VIQ3* / O95239* / kinesin family member 4B* / kinesin family member 4A*ENSMUSG0000003431124
Kif27 / Q7M6Z4 / Kinesin-like protein KIF27 / Q86VH2* / kinesin family member 27*ENSMUSG0000006017624
Kif11 / Q6P9P6 / Kinesin-like protein KIF11 / P52732* / kinesin family member 11*ENSMUSG0000001244324
Kif21b / kinesin family member 21B / O75037*ENSMUSG0000004164224
Kif17 / Q99PW8 / Kinesin-like protein KIF17 / Q9P2E2* / kinesin family member 17*ENSMUSG0000002875824
Kif15 / Q6P9L6 / Kinesin-like protein KIF15 / Q9NS87* / kinesin family member 15*ENSMUSG0000003676823
Kif3b / Q61771 / Kinesin-like protein KIF3B Kinesin-like protein KIF3B, N-terminally processed / O15066* / kinesin family member 3B*ENSMUSG0000002747521
Kif3c / O35066 / Kinesin-like protein KIF3C / O14782* / kinesin family member 3C*ENSMUSG0000002066821
Kif3a / P28741 / Kinesin-like protein KIF3A / Q9Y496* / kinesin family member 3A*ENSMUSG0000001839520


Protein motifs (from Interpro)
Interpro ID Name
 IPR001752  Kinesin motor domain
 IPR019821  Kinesin motor domain, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027640  Kinesin-like protein
 IPR036961  Kinesin motor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006839 mitochondrial transport TAS
 biological_processGO:0007017 microtubule-based process TAS
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007028 cytoplasm organization IMP
 biological_processGO:0007411 axon guidance IBA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008104 protein localization IBA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0031340 positive regulation of vesicle fusion IEA
 biological_processGO:0032230 positive regulation of synaptic transmission, GABAergic IDA
 biological_processGO:0035617 stress granule disassembly IMP
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0043268 positive regulation of potassium ion transport IEA
 biological_processGO:0047496 vesicle transport along microtubule IEA
 biological_processGO:0051642 centrosome localization IEA
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 biological_processGO:0072383 plus-end-directed vesicle transport along microtubule IMP
 biological_processGO:0090316 positive regulation of intracellular protein transport IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:1905152 positive regulation of voltage-gated sodium channel activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005871 kinesin complex TAS
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0030139 endocytic vesicle IDA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0035253 ciliary rootlet IDA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043227 membrane-bounded organelle IDA
 cellular_componentGO:0044295 axonal growth cone IEA
 cellular_componentGO:0045335 phagocytic vesicle IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008432 JUN kinase binding IEA
 molecular_functionGO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IBA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0099609 microtubule lateral binding IEA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
RHO GTPases activate KTN1
COPI-dependent Golgi-to-ER retrograde traffic
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tln2tm2Crit/Tln2tm2Crit
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tln2tm2Crit/Tln2tm2Crit
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tln2tm2Crit/Tln2tm2Crit
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002693 abnormal pancreas physiology "abberrant function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tln2tm2Crit/Tln2tm2Crit
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tln2tm2Crit/Tln2tm2Crit
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Tln2tm2Crit/Tln2tm2Crit
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Kif5btm1Njen/Kif5b+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6N * DBA * SJL

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tln2tm2Crit/Tln2tm2Crit
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003645 increased number of pancreatic beta cells "greater than normal number of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tln2tm2Crit/Tln2tm2Crit
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005058 abnormal lysosome morphology "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tln2tm2Crit/Tln2tm2Crit
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tln2tm2Crit/Tln2tm2Crit
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Kif5btm1Njen/Kif5b+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6N * DBA * SJL

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008546 abnormal vesicle-mediated transport "anomaly in the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell" [GO:0016192]
Show

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Tln2tm2Crit/Tln2tm2Crit
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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