ENSMUSG00000045328


Mus musculus

Features
Gene ID: ENSMUSG00000045328
  
Biological name :Cenpe
  
Synonyms : Cenpe / centromere protein E
  
Possible biological names infered from orthology : Q02224
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G3
Gene start: 135212537
Gene end: 135273611
  
Corresponding Affymetrix probe sets: 10496204 (MoGene1.0st)   1435005_at (Mouse Genome 430 2.0 Array)   1439040_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057938
Ensembl peptide - ENSMUSP00000143435
NCBI entrez gene - 229841     See in Manteia.
MGI - MGI:1098230
RefSeq - NM_173762
RefSeq - XM_017319565
RefSeq Peptide - NP_776123
swissprot - E9QKK1
swissprot - A0A0G2JG58
Ensembl - ENSMUSG00000045328
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cenpeENSDARG00000063385Danio rerio
 ENSGALG00000013208Gallus gallus
 CENPEENSG00000138778Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kif15 / Q6P9L6 / Kinesin-like protein KIF15 / Q9NS87* / kinesin family member 15*ENSMUSG0000003676815
Kif21a / Q9QXL2 / Kinesin-like protein KIF21A / Q7Z4S6* / kinesin family member 21A*ENSMUSG0000002262911
Kif5a / P33175 / Kinesin heavy chain isoform 5A / Q12840* / kinesin family member 5A*ENSMUSG0000007465711
Kif21b / kinesin family member 21B / O75037*ENSMUSG0000004164211
Kif7 / kinesin family member 7 / Q2M1P5*ENSMUSG0000005038211
Kif27 / Q7M6Z4 / Kinesin-like protein KIF27 / Q86VH2* / kinesin family member 27*ENSMUSG0000006017611
Kif4 / P33174 / Chromosome-associated kinesin KIF4 / KIF4A* / KIF4B* / Q2VIQ3* / O95239* / kinesin family member 4B* / kinesin family member 4A*ENSMUSG0000003431111
Kif17 / Q99PW8 / Kinesin-like protein KIF17 / Q9P2E2* / kinesin family member 17*ENSMUSG0000002875810
Kif5b / Q61768 / Kinesin-1 heavy chain / P33176* / kinesin family member 5B*ENSMUSG0000000674010
Kif5c / P28738 / Kinesin heavy chain isoform 5C / O60282* / kinesin family member 5C*ENSMUSG0000002676410
Kif3b / Q61771 / Kinesin-like protein KIF3B Kinesin-like protein KIF3B, N-terminally processed / O15066* / kinesin family member 3B*ENSMUSG000000274759
Kif3a / P28741 / Kinesin-like protein KIF3A / Q9Y496* / kinesin family member 3A*ENSMUSG000000183959
Kif11 / Q6P9P6 / Kinesin-like protein KIF11 / P52732* / kinesin family member 11*ENSMUSG000000124439
Kif3c / O35066 / Kinesin-like protein KIF3C / O14782* / kinesin family member 3C*ENSMUSG000000206688


Protein motifs (from Interpro)
Interpro ID Name
 IPR001752  Kinesin motor domain
 IPR019821  Kinesin motor domain, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027640  Kinesin-like protein
 IPR036961  Kinesin motor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007052 mitotic spindle organization IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0007079 mitotic chromosome movement towards spindle pole IEA
 biological_processGO:0007080 mitotic metaphase plate congression IEA
 biological_processGO:0030071 regulation of mitotic metaphase/anaphase transition IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0051310 metaphase plate congression IEA
 biological_processGO:0051315 attachment of mitotic spindle microtubules to kinetochore IEA
 biological_processGO:0099606 microtubule plus-end directed mitotic chromosome migration IEA
 biological_processGO:0099607 lateral attachment of mitotic spindle microtubules to kinetochore IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000779 condensed chromosome, centromeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005828 kinetochore microtubule IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:1990023 mitotic spindle midzone IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0043515 kinetochore binding IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
COPI-dependent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002658 abnormal liver regeneration "deviation from the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

Allelic Composition: Cenpetm2Dwc/Cenpetm2Dwc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cenpetm1Dwc/Cenpetm2Dwc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004966 abnormal inner cell mass proliferation "any anomaly in the ability of the inner cell mass population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
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Allelic Composition: Cenpetm2Dwc/Cenpetm2Dwc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000045328 Cenpe / centromere protein E / Q02224*  / reaction / complex






 

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