ENSMUSG00000050382


Mus musculus

Features
Gene ID: ENSMUSG00000050382
  
Biological name :Kif7
  
Synonyms : Kif7 / kinesin family member 7
  
Possible biological names infered from orthology : Q2M1P5
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: D2
Gene start: 79698098
Gene end: 79715720
  
Corresponding Affymetrix probe sets: 10564777 (MoGene1.0st)   10564791 (MoGene1.0st)   1439637_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000061806
Ensembl peptide - ENSMUSP00000136993
Ensembl peptide - ENSMUSP00000139224
Ensembl peptide - ENSMUSP00000139359
NCBI entrez gene - 16576     See in Manteia.
MGI - MGI:1098239
RefSeq - XM_006540670
RefSeq - XM_006540666
RefSeq - XM_006540667
RefSeq - XM_006540668
RefSeq - XM_006540669
RefSeq - NM_001291222
RefSeq - NM_010626
RefSeq - XM_006540664
RefSeq - XM_006540665
RefSeq Peptide - NP_034756
RefSeq Peptide - NP_001278151
swissprot - J3QNW9
swissprot - E9QMU1
Ensembl - ENSMUSG00000050382
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kif7ENSDARG00000033099Danio rerio
 KIF7ENSGALG00000006611Gallus gallus
 KIF7ENSG00000166813Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kif27 / Q7M6Z4 / Kinesin-like protein KIF27 / Q86VH2* / kinesin family member 27*ENSMUSG0000006017639
Kif21b / kinesin family member 21B / O75037*ENSMUSG0000004164223
Kif21a / Q9QXL2 / Kinesin-like protein KIF21A / Q7Z4S6* / kinesin family member 21A*ENSMUSG0000002262923
Cenpe / centromere protein E / Q02224*ENSMUSG0000004532821
Kif4 / P33174 / Chromosome-associated kinesin KIF4 / KIF4A* / KIF4B* / Q2VIQ3* / O95239* / kinesin family member 4B* / kinesin family member 4A*ENSMUSG0000003431121
Kif17 / Q99PW8 / Kinesin-like protein KIF17 / Q9P2E2* / kinesin family member 17*ENSMUSG0000002875818
Kif15 / Q6P9L6 / Kinesin-like protein KIF15 / Q9NS87* / kinesin family member 15*ENSMUSG0000003676818
Kif5a / P33175 / Kinesin heavy chain isoform 5A / Q12840* / kinesin family member 5A*ENSMUSG0000007465717
Kif5b / Q61768 / Kinesin-1 heavy chain / P33176* / kinesin family member 5B*ENSMUSG0000000674017
Kif5c / P28738 / Kinesin heavy chain isoform 5C / O60282* / kinesin family member 5C*ENSMUSG0000002676417
Kif3c / O35066 / Kinesin-like protein KIF3C / O14782* / kinesin family member 3C*ENSMUSG0000002066816
Kif11 / Q6P9P6 / Kinesin-like protein KIF11 / P52732* / kinesin family member 11*ENSMUSG0000001244316
Kif3b / Q61771 / Kinesin-like protein KIF3B Kinesin-like protein KIF3B, N-terminally processed / O15066* / kinesin family member 3B*ENSMUSG0000002747515
Kif3a / P28741 / Kinesin-like protein KIF3A / Q9Y496* / kinesin family member 3A*ENSMUSG0000001839515


Protein motifs (from Interpro)
Interpro ID Name
 IPR001752  Kinesin motor domain
 IPR019821  Kinesin motor domain, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027640  Kinesin-like protein
 IPR036961  Kinesin motor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 cellular_componentGO:0005929 cilium IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA


Pathways (from Reactome)
Pathway description
Hedgehog off state
Hedgehog on state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Pcdh15m2Btlr/Pcdh15m2Btlr
Genetic Background: involves: C57BL/6J

 MP:0000153 rib bifurcation "forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rbm15tm1Swm/Rbm15tm1Swm,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Rbm15tm1Swm/Rbm15tm1Swm,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Rbm15tm1Swm/Rbm15tm1Swm,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0000159 abnormal xiphoid process "malformed posterior tip of the sternum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:42932]
Show

Allelic Composition: Rbm15tm1Swm/Rbm15tm1Swm,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0000273 overriding aorta "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]
Show

Allelic Composition: Kif7b2b2254Clo/Kif7b2b2254Clo
Genetic Background: C57BL/6J-Kif7b2b2254Clo

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Kif7b2b2254Clo/Kif7b2b2254Clo
Genetic Background: C57BL/6J-Kif7b2b2254Clo

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rbm15tm1Swm/Rbm15tm1Swm,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Kif7tm1Lex/Kif7tm1Lex
Genetic Background: involves: C57BL/6

Allelic Composition: Kif7b2b2254Clo/Kif7b2b2254Clo
Genetic Background: C57BL/6J-Kif7b2b2254Clo

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kif7b2b2254Clo/Kif7b2b2254Clo
Genetic Background: C57BL/6J-Kif7b2b2254Clo

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Rbm15tm1Swm/Rbm15tm1Swm,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Kif7tm1.2Hui/Kif7tm1.2Hui,Smotm1Amc/Smotm1Amc
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * CD-1

Allelic Composition: Kif7tm1Lex/Kif7tm1Lex
Genetic Background: involves: C57BL/6

Allelic Composition: Kif7b2b2254Clo/Kif7b2b2254Clo
Genetic Background: C57BL/6J-Kif7b2b2254Clo

 MP:0000926 absent floor plate "missing ventral midline thinning of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35802]
Show

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Kif7maki/Kif7maki,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Ift172wim/Ift172wim,Kif7maki/Kif7maki,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Rpl22tm1.2Psam/Rpl22tm1.2Psam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Kif7maki/Kif7maki,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kif7tm1Lex/Kif7tm1Lex
Genetic Background: involves: C57BL/6

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
Show

Allelic Composition: Kif7dda/Kif7dda
Genetic Background: FVB.A-Kif7dda

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
Show

Allelic Composition: Kif7b2b2254Clo/Kif7b2b2254Clo
Genetic Background: C57BL/6J-Kif7b2b2254Clo

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Kif7tm1Lex/Kif7tm1Lex
Genetic Background: involves: C57BL/6

Allelic Composition: Kif7b2b2254Clo/Kif7b2b2254Clo
Genetic Background: C57BL/6J-Kif7b2b2254Clo

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Rbm15tm1Swm/Rbm15tm1Swm,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Kif7tm1Lex/Kif7tm1Lex
Genetic Background: involves: C57BL/6

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Kif7b2b2254Clo/Kif7b2b2254Clo
Genetic Background: C57BL/6J-Kif7b2b2254Clo

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rpl22tm1.2Psam/Rpl22tm1.2Psam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Kif7maki/Kif7maki,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Gli3Xt/?,Kif7maki/Kif7maki,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6J * CBA/H * FVB/N

Allelic Composition: Kif7maki/Kif7maki,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Ift172wim/Ift172wim,Kif7maki/Kif7maki,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Kif7maki/Kif7maki,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

Allelic Composition: Kif7tm1.2Hui/Kif7tm1.2Hui,Smotm1Amc/Smotm1Amc
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * CD-1

Allelic Composition: Gli2tm1Alj/Gli2+,Kif7tm1.2Hui/Kif7tm1.2Hui
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * CD-1

Allelic Composition: Kif7dda/Kif7dda
Genetic Background: FVB.A-Kif7dda

 MP:0003924 herniated diaphragm "protrusion of abdominal contents into the thoracic cavity through the diaphragm" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Allelic Composition: Kif7dda/Kif7dda
Genetic Background: FVB.A-Kif7dda

 MP:0003936 abnormal reproductive system development "developmental anomaly of any of the organs involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kif7b2b2254Clo/Kif7b2b2254Clo
Genetic Background: C57BL/6J-Kif7b2b2254Clo

 MP:0004157 interrupted aortic arch "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kif7b2b2254Clo/Kif7b2b2254Clo
Genetic Background: C57BL/6J-Kif7b2b2254Clo

 MP:0004949 absent neuronal precursor cells "absence of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif7tm1.2Hui/Kif7tm1.2Hui,Smotm1Amc/Smotm1Amc
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * CD-1

 MP:0005170 cleft lip "defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Kif7b2b2254Clo/Kif7b2b2254Clo
Genetic Background: C57BL/6J-Kif7b2b2254Clo

 MP:0005192 increased motor neuron number "greater than the normal number of cells that innervate an effector (muscle or glandular) tissue" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rpl22tm1.2Psam/Rpl22tm1.2Psam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kif7dda/Kif7dda
Genetic Background: FVB.A-Kif7dda

 MP:0005650 abnormal limb bud morphology "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]
Show

Allelic Composition: Kif7tm1Lex/Kif7tm1Lex
Genetic Background: involves: C57BL/6

 MP:0006065 abnormal heart position "the heart is displaced from the normal left-sided position and/or orientation" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kif7dda/Kif7dda
Genetic Background: FVB.A-Kif7dda

 MP:0009743 preaxial polydactyly "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]
Show

Allelic Composition: Rpl22tm1.2Psam/Rpl22tm1.2Psam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Kif7tm1.2Hui/Kif7tm1.2Hui
Genetic Background: involves: 129S6/SvEvTac * CD-1

Allelic Composition: Kif7tm1Lex/Kif7tm1Lex
Genetic Background: involves: C57BL/6

Allelic Composition: Kif7b2b2254Clo/Kif7b2b2254Clo
Genetic Background: C57BL/6J-Kif7b2b2254Clo

 MP:0009744 postaxial polydactyly "duplication of all or part of any of the rays except the first ray on one or more of the autopods" [PMID:19125433]
Show

Allelic Composition: Kif7b2b2254Clo/Kif7b2b2254Clo
Genetic Background: C57BL/6J-Kif7b2b2254Clo

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif7tm1.2Hui/Kif7tm1.2Hui
Genetic Background: involves: 129S6/SvEvTac * CD-1

Allelic Composition: Kif7tm1.2Hui/Kif7tm1.2Hui,Smotm1Amc/Smotm1Amc
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * CD-1

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Kif7dda/Kif7dda
Genetic Background: FVB.A-Kif7dda

Allelic Composition: Kif7b2b2254Clo/Kif7b2b2254Clo
Genetic Background: C57BL/6J-Kif7b2b2254Clo

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
Show

Allelic Composition: Kif7b2b2254Clo/Kif7b2b2254Clo
Genetic Background: C57BL/6J-Kif7b2b2254Clo

 MP:0010460 pulmonary artery hypoplasia "underdevelopment or reduced size of the artery that arises from the right ventricle and conveys unaerated blood to the lungs, usually due to reduced cell number" [MESH:A07.231.114.715]
Show

Allelic Composition: Kif7b2b2254Clo/Kif7b2b2254Clo
Genetic Background: C57BL/6J-Kif7b2b2254Clo

 MP:0010975 abnormal lung lobe morphology "any structural anomaly of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif7b2b2254Clo/Kif7b2b2254Clo
Genetic Background: C57BL/6J-Kif7b2b2254Clo

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Kif7tm1.2Hui/Kif7tm1.2Hui
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Rpl22tm1.2Psam/Rpl22tm1.2Psam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Rpl22tm1.2Psam/Rpl22tm1.2Psam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Kif7maki/Kif7maki,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0012059 thick diaphragm muscle "increased thickness of the diaphragm muscle" [MGI:smb]
Show

Allelic Composition: Kif7dda/Kif7dda
Genetic Background: FVB.A-Kif7dda

 MP:0012060 diaphragm muscle hyperplasia 
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Allelic Composition: Kif7dda/Kif7dda
Genetic Background: FVB.A-Kif7dda

 MP:0012061 abnormal central tendon morphology "any structural anomaly of the three-lobed cloverleaf-shaped aponeurosis situated at the center of the diaphragm; the central tendon is fused with the fibrous pericardium that provides attachment for the muscle fibers" [MGI:csmith]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Allelic Composition: Kif7dda/Kif7dda
Genetic Background: FVB.A-Kif7dda

 MP:0012251 abnormal diaphragm development "malformation or incomplete differentiation of the thin musculomembranous barrier separating the abdominal and thoracic cavities and functioning in respiration" [MGI:anna]
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Allelic Composition: Kif7dda/Kif7dda
Genetic Background: FVB.A-Kif7dda

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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