MP:0000088 | short mandible | "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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MP:0000102 | abnormal nasal bone morphology | "malformed elongated rectangular bone that forms part of the nasal bridge" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489] |
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Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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MP:0000106 | abnormal basisphenoid bone morphology | "malformed base of the sphenoid bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583] |
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Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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MP:0000107 | abnormal frontal bone morphology | "malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489] |
Show
Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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MP:0000131 | abnormal long bone epiphysis morphology | "the head of a developing long bone that is separated from the shaft by the epiphyseal plate" [J:61509] |
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Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0000150 | abnormal rib morphology | "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311] |
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Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0000165 | abnormal hypertrophic chondrocyte zone | "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795] |
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Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0000166 | abnormal chondrocyte morphology | "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203] |
Show
Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0000269 | abnormal looping morphogenesis | "atypical bending of the primitive heart tube during early development" [J:27443] |
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Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Kif3atm1Noh/Kif3atm1Noh Genetic Background: involves: 129S4/SvJae * C57BL/6J
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MP:0000292 | distended pericardial sacs | "stretched outer parietal layer of the pericardium" [J:25248] |
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Allelic Composition: Kif3atm1Noh/Kif3atm1Noh Genetic Background: involves: 129S4/SvJae * C57BL/6J
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MP:0000438 | abnormal skull morphology | "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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MP:0000455 | abnormal maxilla morphology | "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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MP:0000522 | cysts in kidney cortex | "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844] |
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
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MP:0000547 | short limbs | "reduced average length of the extremities" [MGI:CLS, J:61509] |
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Allelic Composition: Jarid2jumonji/Jarid2jumonji Genetic Background: C3.129P2-Jarid2jumonji
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MP:0000562 | polydactyly | "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Jarid2jumonji/Jarid2jumonji Genetic Background: C3.129P2-Jarid2jumonji
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MP:0000930 | wavy neural tube | "undulations in the embryonic neural tube" [J:37888] |
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Allelic Composition: Kif3atm1Noh/Kif3atm1Noh Genetic Background: involves: 129S4/SvJae * C57BL/6J
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MP:0000955 | abnormal spinal cord morphology | "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Jarid2jumonji/Jarid2jumonji Genetic Background: C3.129P2-Jarid2jumonji
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MP:0001300 | ocular hypertelorism | "increased distance between the eyes " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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MP:0001672 | abnormal embryogenesis/ development | "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gpr161tm1Lex/Gpr161tm1Lex,Smotm1Amc/Smotm1Amc Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6N
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MP:0001680 | abnormal mesoderm development | "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Kif3atm1Noh/Kif3atm1Noh Genetic Background: involves: 129S4/SvJae * C57BL/6J
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MP:0001688 | abnormal somite development | "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Kif3atm1Noh/Kif3atm1Noh Genetic Background: involves: 129S4/SvJae * C57BL/6J
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MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
Show
Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Kif3atm1Noh/Kif3atm1Noh Genetic Background: involves: 129S4/SvJae * C57BL/6J
Allelic Composition: Gpr161tm1Lex/Gpr161tm1Lex,Kif3atm1Gsn/Kif3atm1Gsn Genetic Background: involves: 129 * C57BL/6N
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MP:0001700 | abnormal embryo turning | "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0001701 | incomplete embryo turning | "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571] |
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Allelic Composition: Kif3atm1Noh/Kif3atm1Noh Genetic Background: involves: 129S4/SvJae * C57BL/6J
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MP:0001706 | abnormal left-right axis patterning | "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Allelic Composition: Kif3atm1Noh/Kif3atm1Noh Genetic Background: involves: 129S4/SvJae * C57BL/6J
Allelic Composition: Kif3a2a/Kif3a2a Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
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MP:0001787 | pericardial edema | "accumulation of watery fluid in the pericardial sac of the heart" [J:52597] |
Show
Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0001891 | hydroencephaly | "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Kif3atm1Noh/Kif3atm1Noh Genetic Background: involves: 129S4/SvJae * C57BL/6J
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MP:0002084 | abnormal developmental patterning | "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Fgf23tm1Blan/Fgf23+,PhexHyp/Y Genetic Background: Not Specified
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MP:0002116 | abnormal craniofacial bone morphology | "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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MP:0002151 | abnormal neural tube morphology/development | "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ift122sopb/Ift122sopb,Kif3atm1Gsn/Kif3atm1Gsn Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J
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MP:0002152 | abnormal brain morphology | "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk] |
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Allelic Composition: Foxj1tm1.1Ctk/Foxj1tm1.2Ctk,Tg(FOXJ1-EGFP)85Leo/0,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * SJL
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MP:0002196 | acallosal | "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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MP:0002239 | abnormal nasal septum morphology | "any structural anomaly of the structure that separates the two nasal cavities " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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MP:0002427 | dwarfism | "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,Tg(Col2a1-cre)10Amc/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0002766 | situs inversus | "lateral transposition of the viscera of the thorax and abdomen, sometimes incomplete" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0002820 | abnormal premaxilla morphology | "malformation or absence of the anterior and inner portion of the maxilla" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:76662] |
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Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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MP:0003055 | abnormal epiphyseal plate morphology | "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0003068 | enlarged kidney | "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator] |
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
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MP:0003215 | renal interstitial fibrosis | "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission] |
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
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MP:0003606 | kidney failure | "cessation of renal function" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
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MP:0003662 | abnormal proliferative zone | "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254] |
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Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0003675 | kidney cysts | "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
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MP:0003720 | abnormal neural tube closure | "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099] |
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Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0003861 | abnormal nervous system development | "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gpr161tm1Lex/Gpr161tm1Lex,Kif3atm1Gsn/Kif3atm1Gsn Genetic Background: involves: 129 * C57BL/6N
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MP:0003935 | abnormal craniofacial development | "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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MP:0004066 | abnormal Henson s node morphology | "malformation of cells in the small pit at the anterior end of the primitive streak that are important in determining left-right asymmetry" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0004073 | caudal body truncation | "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0004132 | absent embryonic cilia | "absence of cilia on the cells of the embryonic node " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Allelic Composition: Kif3atm1Noh/Kif3atm1Noh Genetic Background: involves: 129S4/SvJae * C57BL/6J
Allelic Composition: Ift122sopb/Ift122sopb,Kif3atm1Gsn/Kif3atm1Gsn Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J
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MP:0004252 | abnormal direction of looping morphogenesis | "deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Allelic Composition: Kif3atm1Noh/Kif3atm1Noh Genetic Background: involves: 129S4/SvJae * C57BL/6J
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MP:0004623 | thoracic vertebral fusion | "the union of one or more thoracic vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0004686 | decreased length of long bones | "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Jarid2jumonji/Jarid2jumonji Genetic Background: C3.129P2-Jarid2jumonji
Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,Tg(Col2a1-cre)1Bhr/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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MP:0004911 | absent mandibular condyloid process | "absence of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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MP:0005202 | lethargy | "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
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MP:0005249 | abnormal palatine bone morphology | "structural anomaly of the anteriorly located rigid section of the palate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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MP:0005297 | spina bifida occulta | "common congenital midline defect of fusion of the vertebral arch without protrusion of the spinal cord or meninges" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0005312 | pericardial effusion | "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Kif3atm1Noh/Kif3atm1Noh Genetic Background: involves: 129S4/SvJae * C57BL/6J
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MP:0005565 | increased blood urea nitrogen level | "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
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MP:0005650 | abnormal limb bud morphology | "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460] |
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Allelic Composition: Jarid2jumonji/Jarid2jumonji Genetic Background: C3.129P2-Jarid2jumonji
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MP:0006279 | abnormal limb development | "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0006346 | small branchial arch | "reduced size of one or more of the branchial arches" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0006396 | decreased long bone epiphyseal plate size | "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Jarid2jumonji/Jarid2jumonji Genetic Background: C3.129P2-Jarid2jumonji
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MP:0006397 | disorganized long bone epiphyseal plate | "a lack of the regular arrangement of the cells or zones of the epiphyseal plate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Jarid2jumonji/Jarid2jumonji Genetic Background: C3.129P2-Jarid2jumonji
Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,Tg(Col2a1-cre)10Amc/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0008272 | abnormal endochondral bone ossification | "anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958] |
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Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,Tg(Col2a1-cre)10Amc/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0008528 | polycystic kidney | "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,Tg(Col2a1-cre)10Amc/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0009328 | delayed heart looping | "late onset of the initiation and/or completion of cardiac looping" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0009890 | cleft secondary palate | "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722] |
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Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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MP:0010029 | abnormal basicranium morphology | "any structural anomaly of the sloping floor of the cranial cavity that is comprised of parts of the ethmoidal, occipital and sphenoid bones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,Tg(Col2a1-cre)10Amc/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0010500 | myocardium hypoplasia | "underdevelopment or reduced size, usually due to a reduced number of cells, of the heart myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kif3atm1Noh/Kif3atm1Noh Genetic Background: involves: 129S4/SvJae * C57BL/6J
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MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Allelic Composition: Kif3atm1Noh/Kif3atm1Noh Genetic Background: involves: 129S4/SvJae * C57BL/6J
Allelic Composition: Kif3a2a/Kif3a2a Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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MP:0011307 | kidney medulla cysts | "abnormal membranous sacs appearing in the inner portion of the kidney which consists of the renal pyramids" [MGI:anna] |
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
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MP:0011346 | renal tubule atrophy | "acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna] |
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
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MP:0011368 | increased kidney apoptosis | "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna] |
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
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MP:0012093 | absent nodal flow | "absence of the leftward movement of extra-embryonic fluid at the ventral node; nodal flow is autonomously generated by the rotation of cilia that are tilted toward the posterior on cells of the ventral node and is the central process in symmetry breaking on the left-right axis; when nodal cilia are immotile or absent, nodal flow does not occur" [MGI:anna] |
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Allelic Composition: Kif3atm1Noh/Kif3atm1Noh Genetic Background: involves: 129S4/SvJae * C57BL/6J
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MP:0012509 | neural tube degeneration | "a retrogressive impairment of function or destruction of the hollow epithelial tube found on the dorsal side of the vertebrate embryo that develops into the central nervous system (i.e. brain and spinal cord)" [MGI:anna] |
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Allelic Composition: Kif3atm1Noh/Kif3atm1Noh Genetic Background: involves: 129S4/SvJae * C57BL/6J
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MP:0012754 | abnormal cranial neural crest cell morphology | "any structural anomaly of the neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage" [http://discovery.lifemapsc.com/in-vivo-development/neural-crest/cranial-neural-crest, http://embryology.med.unsw.edu.au/embryology/index.php?title=Neural_Crest_Development#Cranial_neural_crest, http://en.wikipedia.org/wiki/Cranial_neural_crest, MGI:anna] |
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Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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MP:0012759 | increased cranial neural crest cell proliferation | "enhanced ability of the cranial neural crest cells (NCCs) to undergo rapid expansion by cell division" [MGI:anna] |
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Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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MP:0020378 | abnormal cell cytoskeleton morphology | "any anomaly in the structure of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm" [GO:0005856, MGI:mberry] |
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Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,Tg(Col2a1-cre)1Bhr/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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MP:0020384 | absent kidney epithelial cell primary cilium | "absence of non-motile cilia on cells of the renal tubule or collecting duct" [ORCID: orcid.org/0000-0003-4606-0597] |
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
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MP:0030251 | broad frontonasal prominence | "increased width of the unpaired embryonic process that is formed from the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout" [MGI:anna] |
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Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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MP:0030269 | absent mandibular ramus | "absence of the upturned perpendicular extremity of the mandible" [MGI:anna] |
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Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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MP:0030276 | anterior cranium occultum | "presence of an abnormal skin-covered gap in the front of the head, usually due to increased distance between the frontal bones" [PMID:20106874] |
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Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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