ENSMUSG00000041642


Mus musculus

Features
Gene ID: ENSMUSG00000041642
  
Biological name :Kif21b
  
Synonyms : Kif21b / kinesin family member 21B
  
Possible biological names infered from orthology : O75037
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E4
Gene start: 136131389
Gene end: 136177998
  
Corresponding Affymetrix probe sets: 10350247 (MoGene1.0st)   1421119_at (Mouse Genome 430 2.0 Array)   1435772_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000074661
Ensembl peptide - ENSMUSP00000114297
Ensembl peptide - ENSMUSP00000131815
NCBI entrez gene - 16565     See in Manteia.
MGI - MGI:109234
RefSeq - NM_001039472
RefSeq Peptide - NP_001034561
swissprot - F8VQE2
swissprot - F6ZSF2
swissprot - E9Q0A4
Ensembl - ENSMUSG00000041642
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kif21bENSDARG00000009733Danio rerio
 KIF21BENSGALG00000034347Gallus gallus
 KIF21BENSG00000116852Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kif21a / Q9QXL2 / Kinesin-like protein KIF21A / Q7Z4S6* / kinesin family member 21A*ENSMUSG0000002262961
Kif4 / P33174 / Chromosome-associated kinesin KIF4 / KIF4A* / KIF4B* / Q2VIQ3* / O95239* / kinesin family member 4B* / kinesin family member 4A*ENSMUSG0000003431121
Kif27 / Q7M6Z4 / Kinesin-like protein KIF27 / Q86VH2* / kinesin family member 27*ENSMUSG0000006017620
Kif7 / kinesin family member 7 / Q2M1P5*ENSMUSG0000005038219
Kif15 / Q6P9L6 / Kinesin-like protein KIF15 / Q9NS87* / kinesin family member 15*ENSMUSG0000003676816
Kif17 / Q99PW8 / Kinesin-like protein KIF17 / Q9P2E2* / kinesin family member 17*ENSMUSG0000002875816
Cenpe / centromere protein E / Q02224*ENSMUSG0000004532816
Kif5a / P33175 / Kinesin heavy chain isoform 5A / Q12840* / kinesin family member 5A*ENSMUSG0000007465716
Kif5c / P28738 / Kinesin heavy chain isoform 5C / O60282* / kinesin family member 5C*ENSMUSG0000002676415
Kif11 / Q6P9P6 / Kinesin-like protein KIF11 / P52732* / kinesin family member 11*ENSMUSG0000001244314
Kif5b / Q61768 / Kinesin-1 heavy chain / P33176* / kinesin family member 5B*ENSMUSG0000000674014
Kif3b / Q61771 / Kinesin-like protein KIF3B Kinesin-like protein KIF3B, N-terminally processed / O15066* / kinesin family member 3B*ENSMUSG0000002747513
Kif3a / P28741 / Kinesin-like protein KIF3A / Q9Y496* / kinesin family member 3A*ENSMUSG0000001839512
Kif3c / O35066 / Kinesin-like protein KIF3C / O14782* / kinesin family member 3C*ENSMUSG0000002066812


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR001752  Kinesin motor domain
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR019821  Kinesin motor domain, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027640  Kinesin-like protein
 IPR036322  WD40-repeat-containing domain superfamily
 IPR036961  Kinesin motor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA


Pathways (from Reactome)
Pathway description
COPI-dependent Golgi-to-ER retrograde traffic
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005632 decreased circulating aspartate transaminase level "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Hcfc2em1Btlr/Hcfc2em1Btlr
Genetic Background: C57BL/6J-Hcfc2em1Btlr

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hcfc2em1Btlr/Hcfc2em1Btlr
Genetic Background: C57BL/6J-Hcfc2em1Btlr

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
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Allelic Composition: Hcfc2em1Btlr/Hcfc2em1Btlr
Genetic Background: C57BL/6J-Hcfc2em1Btlr

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
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Allelic Composition: Hcfc2em1Btlr/Hcfc2em1Btlr
Genetic Background: C57BL/6J-Hcfc2em1Btlr

 MP:0020338 abnormal hippocampal pyramidal neuron dendrite morphology "structural anomaly of the highly branched tree-like process of the hippocampal neurons that have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base" [CL_1001571, ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Hcfc2em1Btlr/Hcfc2em1Btlr
Genetic Background: C57BL/6J-Hcfc2em1Btlr

 MP:0020508 decreased dendritic spine density "decrease in the number of dendritic spines in a given cross-sectional area of a dendrite" [MGI:smb]
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Allelic Composition: Hcfc2em1Btlr/Hcfc2em1Btlr
Genetic Background: C57BL/6J-Hcfc2em1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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