ENSMUSG00000020668


Mus musculus

Features
Gene ID: ENSMUSG00000020668
  
Biological name :Kif3c
  
Synonyms : Kif3c / Kinesin-like protein KIF3C / O35066
  
Possible biological names infered from orthology : kinesin family member 3C / O14782
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A1.1
Gene start: 3365132
Gene end: 3406494
  
Corresponding Affymetrix probe sets: 10394158 (MoGene1.0st)   1434947_at (Mouse Genome 430 2.0 Array)   1448946_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020999
Ensembl peptide - ENSMUSP00000151286
Ensembl peptide - ENSMUSP00000151953
NCBI entrez gene - 16570     See in Manteia.
MGI - MGI:107979
RefSeq - NM_008445
RefSeq Peptide - NP_032471
swissprot - O35066
swissprot - Q3UT07
Ensembl - ENSMUSG00000020668
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kif3caENSDARG00000017162Danio rerio
 kif3cbENSDARG00000079500Danio rerio
 KIF3CENSGALG00000026973Gallus gallus
 KIF3CENSG00000084731Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kif3b / Q61771 / Kinesin-like protein KIF3B Kinesin-like protein KIF3B, N-terminally processed / O15066* / kinesin family member 3B*ENSMUSG0000002747562
Kif3a / P28741 / Kinesin-like protein KIF3A / Q9Y496* / kinesin family member 3A*ENSMUSG0000001839540
Kif17 / Q99PW8 / Kinesin-like protein KIF17 / Q9P2E2* / kinesin family member 17*ENSMUSG0000002875837
Kif11 / Q6P9P6 / Kinesin-like protein KIF11 / P52732* / kinesin family member 11*ENSMUSG0000001244328
Kif7 / kinesin family member 7 / Q2M1P5*ENSMUSG0000005038227
Cenpe / centromere protein E / Q02224*ENSMUSG0000004532826
Kif27 / Q7M6Z4 / Kinesin-like protein KIF27 / Q86VH2* / kinesin family member 27*ENSMUSG0000006017626
Kif5a / P33175 / Kinesin heavy chain isoform 5A / Q12840* / kinesin family member 5A*ENSMUSG0000007465726
Kif5b / Q61768 / Kinesin-1 heavy chain / P33176* / kinesin family member 5B*ENSMUSG0000000674026
Kif15 / Q6P9L6 / Kinesin-like protein KIF15 / Q9NS87* / kinesin family member 15*ENSMUSG0000003676825
Kif21a / Q9QXL2 / Kinesin-like protein KIF21A / Q7Z4S6* / kinesin family member 21A*ENSMUSG0000002262925
Kif21b / kinesin family member 21B / O75037*ENSMUSG0000004164225
Kif5c / P28738 / Kinesin heavy chain isoform 5C / O60282* / kinesin family member 5C*ENSMUSG0000002676425
Kif4 / P33174 / Chromosome-associated kinesin KIF4 / KIF4A* / KIF4B* / Q2VIQ3* / O95239* / kinesin family member 4B* / kinesin family member 4A*ENSMUSG0000003431125


Protein motifs (from Interpro)
Interpro ID Name
 IPR001752  Kinesin motor domain
 IPR019821  Kinesin motor domain, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027640  Kinesin-like protein
 IPR036961  Kinesin motor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0072384 organelle transport along microtubule IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005871 kinesin complex IBA
 cellular_componentGO:0005874 microtubule ISO
 cellular_componentGO:0043025 neuronal cell body ISO
 cellular_componentGO:0071598 neuronal ribonucleoprotein granule ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0016887 ATPase activity IBA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
Intraflagellar transport
COPI-dependent Golgi-to-ER retrograde traffic
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Kcnj11tm1b(EUCOMM)Wtsi/Kcnj11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcnj11tm1b(EUCOMM)Wtsi/H

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Kcnj11tm1b(EUCOMM)Wtsi/Kcnj11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcnj11tm1b(EUCOMM)Wtsi/H

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Kif3ctm1Gsn/Kif3ctm1Gsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Kif3ctm2Gsn/Kif3ctm2Gsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnj11tm1b(EUCOMM)Wtsi/Kcnj11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcnj11tm1b(EUCOMM)Wtsi/H

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Fzd4tm1.1(KOMP)Vlcg/Fzd4tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fzd4tm1.1(KOMP)Vlcg/Ucd

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
Show

Allelic Composition: Kcnj11tm1b(EUCOMM)Wtsi/Kcnj11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcnj11tm1b(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026585 Kifap3 / P70188 / Kinesin-associated protein 3 / Q92845*  / complex / reaction
 ENSMUSG00000018395 Kif3a / P28741 / Kinesin-like protein KIF3A / Q9Y496* / kinesin family member 3A*  / complex / reaction
 ENSMUSG00000001105 Ift20 / Q61025 / Intraflagellar transport / Q8IY31* / intraflagellar transport 20*  / complex / reaction






 

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