ENSMUSG00000001105


Mus musculus

Features
Gene ID: ENSMUSG00000001105
  
Biological name :Ift20
  
Synonyms : Ift20 / Intraflagellar transport / Q61025
  
Possible biological names infered from orthology : intraflagellar transport 20 / Q8IY31
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 78536361
Gene end: 78541737
  
Corresponding Affymetrix probe sets: 10379215 (MoGene1.0st)   1451412_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000051699
Ensembl peptide - ENSMUSP00000103910
Ensembl peptide - ENSMUSP00000118015
NCBI entrez gene - 55978     See in Manteia.
MGI - MGI:1915585
RefSeq - NM_018854
RefSeq Peptide - NP_061342
swissprot - Q61025
swissprot - Z4YJL9
Ensembl - ENSMUSG00000001105
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ift20ENSDARG00000040556Danio rerio
 IFT20ENSGALG00000005707Gallus gallus
 IFT20ENSG00000109083Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR028172  Intraflagellar transport protein 20


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001736 establishment of planar polarity IMP
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0007224 smoothened signaling pathway IMP
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0022008 neurogenesis IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0034067 protein localization to Golgi apparatus ISO
 biological_processGO:0035845 photoreceptor cell outer segment organization IMP
 biological_processGO:0036372 opsin transport IMP
 biological_processGO:0042073 intraciliary transport IMP
 biological_processGO:0051642 centrosome localization IMP
 biological_processGO:0055007 cardiac muscle cell differentiation IMP
 biological_processGO:0060122 inner ear receptor cell stereocilium organization IMP
 biological_processGO:0060271 cilium assembly ISO
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IMP
 biological_processGO:0061351 neural precursor cell proliferation IMP
 biological_processGO:0061512 protein localization to cilium ISO
 biological_processGO:0072659 protein localization to plasma membrane IMP
 biological_processGO:0090102 cochlea development IMP
 biological_processGO:1902017 regulation of cilium assembly IMP
 biological_processGO:2000785 regulation of autophagosome assembly IMP
 cellular_componentGO:0001750 photoreceptor outer segment IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005801 cis-Golgi network ISO
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005902 microvillus IDA
 cellular_componentGO:0005929 cilium TAS
 cellular_componentGO:0030992 intraciliary transport particle B IDA
 cellular_componentGO:0031514 motile cilium IDA
 cellular_componentGO:0032391 photoreceptor connecting cilium IDA
 cellular_componentGO:0032420 stereocilium IDA
 cellular_componentGO:0036064 ciliary basal body IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0044292 dendrite terminus IDA
 cellular_componentGO:0097546 ciliary base IDA
 cellular_componentGO:1902636 kinociliary basal body IDA
 molecular_functionGO:0002046 opsin binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017137 Rab GTPase binding ISO


Pathways (from Reactome)
Pathway description
Intraflagellar transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm13.1(cre/Esr1*)Ysa
Genetic Background: Not Specified

 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm13.1(cre/Esr1*)Ysa
Genetic Background: Not Specified

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm13.1(cre/Esr1*)Ysa
Genetic Background: Not Specified

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm13.1(cre/Esr1*)Ysa
Genetic Background: Not Specified

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm13.1(cre/Esr1*)Ysa
Genetic Background: Not Specified

 MP:0004860 dilated kidney collecting duct "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm13.1(cre/Esr1*)Ysa
Genetic Background: Not Specified

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm13.1(cre/Esr1*)Ysa
Genetic Background: Not Specified

 MP:0005571 decreased lactate dehydrogenase level "less than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm13.1(cre/Esr1*)Ysa
Genetic Background: Not Specified

 MP:0011440 increased kidney cell proliferation "increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]
Show

Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm13.1(cre/Esr1*)Ysa
Genetic Background: Not Specified

 MP:0011843 abnormal kidney collecting duct epithelium morphology "any structural anomaly of the simple cuboidal epithelium lining the lumen of kidney collecting ducts; the mature and differentiated CD epithelium comprises two unique cells types with principal cells responsible for vasopressin-regulated water reabsorption, and intercalated cells regulating acid-base homeostasis; injury to the epithelium is believed to cause epithelial cells to acquire mesenchymal characteristics via epithelial-mesenchymal transition (EMT), a process through which tubular epithelial cells may transform into interstitial fibroblasts and promote renal fibrosis" [MGI:anna]
Show

Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm13.1(cre/Esr1*)Ysa
Genetic Background: Not Specified

 MP:0020384 absent kidney epithelial cell primary cilium "absence of non-motile cilia on cells of the renal tubule or collecting duct" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm13.1(cre/Esr1*)Ysa
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020668 Kif3c / O35066 / Kinesin-like protein KIF3C / O14782* / kinesin family member 3C*  / complex / reaction
 ENSMUSG00000026585 Kifap3 / P70188 / Kinesin-associated protein 3 / Q92845*  / complex / reaction
 ENSMUSG00000027475 Kif3b / Q61771 / Kinesin-like protein KIF3B Kinesin-like protein KIF3B, N-terminally processed / O15066* / kinesin family member 3B*  / complex / reaction
 ENSMUSG00000034292 Q149C2 / Traf3ip1 / TRAF3 interacting protein 1 / Q8TDR0*  / reaction / complex
 ENSMUSG00000018395 Kif3a / P28741 / Kinesin-like protein KIF3A / Q9Y496* / kinesin family member 3A*  / complex / reaction






 

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