ENSMUSG00000026585


Mus musculus

Features
Gene ID: ENSMUSG00000026585
  
Biological name :Kifap3
  
Synonyms : Kifap3 / Kinesin-associated protein 3 / P70188
  
Possible biological names infered from orthology : Q92845
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H2.1
Gene start: 163779583
Gene end: 163917109
  
Corresponding Affymetrix probe sets: 10351140 (MoGene1.0st)   1417181_a_at (Mouse Genome 430 2.0 Array)   1451783_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027877
Ensembl peptide - ENSMUSP00000076830
NCBI entrez gene - 16579     See in Manteia.
MGI - MGI:107566
RefSeq - XM_006496681
RefSeq - NM_001305643
RefSeq - NM_010629
RefSeq - XM_006496679
RefSeq Peptide - NP_001292572
RefSeq Peptide - NP_034759
swissprot - P70188
Ensembl - ENSMUSG00000026585
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kifap3aENSDARG00000008639Danio rerio
 kifap3bENSDARG00000006862Danio rerio
 KIFAP3ENSGALG00000021047Gallus gallus
 KIFAP3ENSG00000075945Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR008658  Kinesin-associated protein 3
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007017 microtubule-based process IPI
 biological_processGO:0008104 protein localization IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0046587 positive regulation of calcium-dependent cell-cell adhesion IMP
 cellular_componentGO:0000794 condensed nuclear chromosome IEA
 cellular_componentGO:0001917 photoreceptor inner segment IC
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005871 kinesin complex IEA
 cellular_componentGO:0005876 spindle microtubule IEA
 cellular_componentGO:0005930 axoneme IDA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0016939 kinesin II complex IPI
 cellular_componentGO:0030990 intraciliary transport particle IDA
 cellular_componentGO:0032391 photoreceptor connecting cilium IDA
 cellular_componentGO:0036064 ciliary basal body IDA
 cellular_componentGO:1990075 periciliary membrane compartment IDA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019894 kinesin binding ISO


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
Intraflagellar transport
COPI-dependent Golgi-to-ER retrograde traffic
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Atp8a2wl-vmd/Atp8a2wl-vmd
Genetic Background: C3H/HeSnJ-Atp8a2wl-vmd/J

 MP:0000786 abnormal neuroepithelial layer differentiation "malformation or arrest of differentiation or patterning of the epithelial layer of the brain" [J:45302]
Show

Allelic Composition: Atp8a2wl-vmd/Atp8a2wl-vmd
Genetic Background: C3H/HeSnJ-Atp8a2wl-vmd/J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Atp8a2wl-vmd/Atp8a2wl-vmd
Genetic Background: C3H/HeSnJ-Atp8a2wl-vmd/J

 MP:0000846 abnormal medulla oblongata "anomaly in the most caudal region of the brainstem that lies directly rostral to the spinal cord; includes regions responsible for autonomic functions such as digestion, breathing and control of heart rate" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp8a2wl-vmd/Atp8a2wl-vmd
Genetic Background: C3H/HeSnJ-Atp8a2wl-vmd/J

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0001092 abnormal trigeminal ganglion morphology "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Atp8a2wl-vmd/Atp8a2wl-vmd
Genetic Background: C3H/HeSnJ-Atp8a2wl-vmd/J

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0003105 abnormal heart atrium morphology "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0003653 decreased skin turgor "reduced ability of the skin to resist deformation; influential factors include dehydration and age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0005238 increased brain size "larger than the normal physical proportions of the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57958]
Show

Allelic Composition: Atp8a2wl-vmd/Atp8a2wl-vmd
Genetic Background: C3H/HeSnJ-Atp8a2wl-vmd/J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0006113 abnormal heart septum morphology "abnormality in the wall between the atria or ventricles of the heart, usually incomplete closure" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0010019 liver vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Atp8a2wl-vmd/Atp8a2wl-vmd
Genetic Background: C3H/HeSnJ-Atp8a2wl-vmd/J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0013182 increased spinal cord apoptosis "increase in the number of cells of the neural tube undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020668 Kif3c / O35066 / Kinesin-like protein KIF3C / O14782* / kinesin family member 3C*  / complex / reaction
 ENSMUSG00000018395 Kif3a / P28741 / Kinesin-like protein KIF3A / Q9Y496* / kinesin family member 3A*  / complex / reaction
 ENSMUSG00000001105 Ift20 / Q61025 / Intraflagellar transport / Q8IY31* / intraflagellar transport 20*  / complex / reaction
 ENSMUSG00000027475 Kif3b / Q61771 / Kinesin-like protein KIF3B Kinesin-like protein KIF3B, N-terminally processed / O15066* / kinesin family member 3B*  / complex / reaction
 ENSMUSG00000019478 Rab4a / P56371 / Ras-related protein Rab-4A / P20338* / RAB4A, member RAS oncogene family*  / reaction / complex






 

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