ENSMUSG00000028758


Mus musculus

Features
Gene ID: ENSMUSG00000028758
  
Biological name :Kif17
  
Synonyms : Kif17 / Kinesin-like protein KIF17 / Q99PW8
  
Possible biological names infered from orthology : kinesin family member 17 / Q9P2E2
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D3
Gene start: 138250435
Gene end: 138301967
  
Corresponding Affymetrix probe sets: 10509526 (MoGene1.0st)   1419826_at (Mouse Genome 430 2.0 Array)   1419827_s_at (Mouse Genome 430 2.0 Array)   1422762_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101444
Ensembl peptide - ENSMUSP00000101447
Ensembl peptide - ENSMUSP00000030539
NCBI entrez gene - 16559     See in Manteia.
MGI - MGI:1098229
RefSeq - NM_010623
RefSeq - NM_001190978
RefSeq Peptide - NP_001177907
RefSeq Peptide - NP_034753
swissprot - Q99PW8
swissprot - A2AM74
swissprot - A2AM72
Ensembl - ENSMUSG00000028758
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kif17ENSDARG00000055238Danio rerio
 KIF17ENSG00000117245Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kif3b / Q61771 / Kinesin-like protein KIF3B Kinesin-like protein KIF3B, N-terminally processed / O15066* / kinesin family member 3B*ENSMUSG0000002747530
Kif3c / O35066 / Kinesin-like protein KIF3C / O14782* / kinesin family member 3C*ENSMUSG0000002066829
Kif3a / P28741 / Kinesin-like protein KIF3A / Q9Y496* / kinesin family member 3A*ENSMUSG0000001839528
Kif21a / Q9QXL2 / Kinesin-like protein KIF21A / Q7Z4S6* / kinesin family member 21A*ENSMUSG0000002262926
Kif15 / Q6P9L6 / Kinesin-like protein KIF15 / Q9NS87* / kinesin family member 15*ENSMUSG0000003676825
Kif21b / kinesin family member 21B / O75037*ENSMUSG0000004164225
Kif11 / Q6P9P6 / Kinesin-like protein KIF11 / P52732* / kinesin family member 11*ENSMUSG0000001244324
Kif27 / Q7M6Z4 / Kinesin-like protein KIF27 / Q86VH2* / kinesin family member 27*ENSMUSG0000006017624
Kif7 / kinesin family member 7 / Q2M1P5*ENSMUSG0000005038224
Cenpe / centromere protein E / Q02224*ENSMUSG0000004532823
Kif4 / P33174 / Chromosome-associated kinesin KIF4 / KIF4A* / KIF4B* / Q2VIQ3* / O95239* / kinesin family member 4B* / kinesin family member 4A*ENSMUSG0000003431123
Kif5c / P28738 / Kinesin heavy chain isoform 5C / O60282* / kinesin family member 5C*ENSMUSG0000002676422
Kif5b / Q61768 / Kinesin-1 heavy chain / P33176* / kinesin family member 5B*ENSMUSG0000000674022
Kif5a / P33175 / Kinesin heavy chain isoform 5A / Q12840* / kinesin family member 5A*ENSMUSG0000007465722


Protein motifs (from Interpro)
Interpro ID Name
 IPR001752  Kinesin motor domain
 IPR019821  Kinesin motor domain, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027640  Kinesin-like protein
 IPR036961  Kinesin motor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007017 microtubule-based process IDA
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IDA
 biological_processGO:0022008 neurogenesis IBA
 biological_processGO:0030030 cell projection organization IBA
 biological_processGO:0031503 protein-containing complex localization IMP
 biological_processGO:0042073 intraciliary transport IC
 biological_processGO:0098971 anterograde dendritic transport of neurotransmitter receptor complex IMP
 cellular_componentGO:0001917 photoreceptor inner segment IC
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005871 kinesin complex IDA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0005930 axoneme IDA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0030992 intraciliary transport particle B IDA
 cellular_componentGO:0032391 photoreceptor connecting cilium IDA
 cellular_componentGO:0032839 dendrite cytoplasm IEA
 cellular_componentGO:0036064 ciliary basal body ISO
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:1990075 periciliary membrane compartment IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IBA


Pathways (from Reactome)
Pathway description
Intraflagellar transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Mecp2tm1.1Mitoh/Mecp2tm1.1Mitoh
Genetic Background: Not Specified

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Mecp2tm1.1Mitoh/Mecp2tm1.1Mitoh
Genetic Background: Not Specified

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Mecp2tm1.1Mitoh/Mecp2tm1.1Mitoh
Genetic Background: Not Specified

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mecp2tm1.1Mitoh/Mecp2tm1.1Mitoh
Genetic Background: Not Specified

 MP:0001902 reduced NMDA -mediated synaptic currents "reduction in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mecp2tm1.1Mitoh/Mecp2tm1.1Mitoh
Genetic Background: Not Specified

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Mecp2tm1.1Mitoh/Mecp2tm1.1Mitoh
Genetic Background: Not Specified

 MP:0004768 abnormal axonal transport "any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mecp2tm1.1Mitoh/Mecp2tm1.1Mitoh
Genetic Background: Not Specified

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mecp2tm1.1Mitoh/Mecp2tm1.1Mitoh
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028758 Kif17 / Q99PW8 / Kinesin-like protein KIF17 / Q9P2E2* / kinesin family member 17*  / complex
 ENSMUSG00000009470 Tnpo1 / Q8BFY9 / transportin 1 / Q92973*  / complex / reaction






 

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