ENSMUSG00000012443


Mus musculus

Features
Gene ID: ENSMUSG00000012443
  
Biological name :Kif11
  
Synonyms : Kif11 / Kinesin-like protein KIF11 / Q6P9P6
  
Possible biological names infered from orthology : kinesin family member 11 / P52732
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C2
Gene start: 37376403
Gene end: 37421859
  
Corresponding Affymetrix probe sets: 10462796 (MoGene1.0st)   1435306_a_at (Mouse Genome 430 2.0 Array)   1452314_at (Mouse Genome 430 2.0 Array)   1452315_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000012587
NCBI entrez gene - 16551     See in Manteia.
MGI - MGI:1098231
RefSeq - NM_010615
RefSeq Peptide - NP_034745
swissprot - Q6P9P6
Ensembl - ENSMUSG00000012443
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kif11ENSDARG00000010948Danio rerio
 KIF11ENSGALG00000030597Gallus gallus
 KIF11ENSG00000138160Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kif17 / Q99PW8 / Kinesin-like protein KIF17 / Q9P2E2* / kinesin family member 17*ENSMUSG0000002875824
Kif5b / Q61768 / Kinesin-1 heavy chain / P33176* / kinesin family member 5B*ENSMUSG0000000674022
Cenpe / centromere protein E / Q02224*ENSMUSG0000004532822
Kif21a / Q9QXL2 / Kinesin-like protein KIF21A / Q7Z4S6* / kinesin family member 21A*ENSMUSG0000002262922
Kif5a / P33175 / Kinesin heavy chain isoform 5A / Q12840* / kinesin family member 5A*ENSMUSG0000007465721
Kif5c / P28738 / Kinesin heavy chain isoform 5C / O60282* / kinesin family member 5C*ENSMUSG0000002676421
Kif21b / kinesin family member 21B / O75037*ENSMUSG0000004164221
Kif3b / Q61771 / Kinesin-like protein KIF3B Kinesin-like protein KIF3B, N-terminally processed / O15066* / kinesin family member 3B*ENSMUSG0000002747521
Kif15 / Q6P9L6 / Kinesin-like protein KIF15 / Q9NS87* / kinesin family member 15*ENSMUSG0000003676821
Kif3c / O35066 / Kinesin-like protein KIF3C / O14782* / kinesin family member 3C*ENSMUSG0000002066821
Kif3a / P28741 / Kinesin-like protein KIF3A / Q9Y496* / kinesin family member 3A*ENSMUSG0000001839521
Kif4 / P33174 / Chromosome-associated kinesin KIF4 / KIF4A* / KIF4B* / Q2VIQ3* / O95239* / kinesin family member 4B* / kinesin family member 4A*ENSMUSG0000003431121
Kif7 / kinesin family member 7 / Q2M1P5*ENSMUSG0000005038220
Kif27 / Q7M6Z4 / Kinesin-like protein KIF27 / Q86VH2* / kinesin family member 27*ENSMUSG0000006017620


Protein motifs (from Interpro)
Interpro ID Name
 IPR001752  Kinesin motor domain
 IPR019821  Kinesin motor domain, conserved site
 IPR025901  Kinesin-associated microtubule-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027640  Kinesin-like protein
 IPR036961  Kinesin motor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IBA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007051 spindle organization IEA
 biological_processGO:0007059 chromosome segregation IBA
 biological_processGO:0007100 mitotic centrosome separation IMP
 biological_processGO:0046602 regulation of mitotic centrosome separation IEA
 biological_processGO:0051225 spindle assembly IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0090307 mitotic spindle assembly IEA
 cellular_componentGO:0000922 spindle pole ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005871 kinesin complex IBA
 cellular_componentGO:0005874 microtubule ISO
 cellular_componentGO:0005876 spindle microtubule IEA
 cellular_componentGO:0072686 mitotic spindle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IBA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
COPI-dependent Golgi-to-ER retrograde traffic
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001728 failure of implantation "inability of the blastocyst to attach to the endometrium of the uterus" [J:38772]
Show

Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Tsc2tm1Mjg/Tsc2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003694 failure to hatch from the zona pellucida "the embryo fails to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0006204 embryonic lethality before implantation "death anytime after fertilization but before implantation (E0 to less than E4.5)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0009781 abnormal preimplantation embryo development "an anomaly in the developmental progress of an embryo from 2 cell to blastocyst affecting the viability or number of embryos" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tsc2tm1Mjg/Tsc2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Tsc2tm1Mjg/Tsc2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011104 partial embryonic lethality before implantation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Tsc2tm1Mjg/Tsc2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012111 failure of morula compaction "inability to initiate or maintain the first cell differentiation event in mammalian development, occurring at the late eight-cell stage in the mouse, whereby cells on the outer part of the morula become flattened and bound tightly together with the formation of desmosomes and gap junctions, becoming nearly indistinguishable" [MGI:anna]
Show

Allelic Composition: Tsc2tm1Mjg/Tsc2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000012443 Kif11 / Q6P9P6 / Kinesin-like protein KIF11 / P52732* / kinesin family member 11*  / reaction / complex






 

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