ENSDARG00000087538


Danio rerio

Features
Gene ID: ENSDARG00000087538
  
Biological name :kif3a
  
Synonyms : kif3a / kinesin family member 3A
  
Possible biological names infered from orthology : Kinesin-like protein KIF3A / P28741 / Q9Y496
  
Species: Danio rerio
  
Chr. number: 14
Strand: 1
Band:
Gene start: 23970818
Gene end: 23999566
  
Corresponding Affymetrix probe sets: Dr.3264.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000107221
Ensembl peptide - ENSDARP00000106255
NCBI entrez gene - 550267     See in Manteia.
RefSeq - NM_001017604
RefSeq Peptide - NP_001017604
swissprot - E9QB71
swissprot - Q568I3
ZFIN ID - ZDB-GENE-050417-71
Ensembl - ENSDARG00000087538
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KIF3AENSGALG00000006860Gallus gallus
 KIF3AENSG00000131437Homo sapiens
 Kif3aENSMUSG00000018395Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
kif3b / kinesin family member 3B / O15066* / Q61771* / Kinesin-like protein KIF3B Kinesin-like protein KIF3B, N-terminally processed*ENSDARG0000010112049
kif3ca / kinesin family member 3Ca / KIF3C* / O14782* / kinesin family member 3C*ENSDARG0000001716245
kif3cb / kinesin family member 3Cb / KIF3C* / O14782* / O35066* / kinesin family member 3C* / Kinesin-like protein KIF3C *ENSDARG0000007950044
kif17 / kinesin family member 17 / Q99PW8* / Q9P2E2* / Kinesin-like protein KIF17 *ENSDARG0000005523841
kif11 / kinesin family member 11 / P52732* / Q6P9P6* / Kinesin-like protein KIF11 *ENSDARG0000001094831
kif15 / kinesin family member 15 / Q6P9L6* / Q9NS87* / Kinesin-like protein KIF15 *ENSDARG0000001207330
kif4 / kinesin family member 4 / KIF4A* / KIF4B* / Q2VIQ3* / O95239* / P33174* / kinesin family member 4A* / kinesin family member 4B* / Chromosome-associated kinesin KIF4 *ENSDARG0000000546230
kif5aa / kinesin family member 5A, a / KIF5A* / Q12840* / kinesin family member 5A*ENSDARG0000009893630
kif21a / kinesin family member 21A / Q7Z4S6* / Q9QXL2* / Kinesin-like protein KIF21A *ENSDARG0000006113130
kif5c / kinesin family member 5C / O60282* / P28738* / Kinesin heavy chain isoform 5C *ENSDARG0000007602729
kif7 / kinesin family member 7 / Q2M1P5*ENSDARG0000003309929
cenpe / centromere protein E / Q02224*ENSDARG0000006338528
kif21b / kinesin family member 21B / O75037*ENSDARG0000000973328
kif5ab / kinesin family member 5A, b / KIF5A* / P33175* / Q12840* / kinesin family member 5A* / Kinesin heavy chain isoform 5A *ENSDARG0000005981827
kif5ba / kif5bb / kinesin family member 5B, b / KIF5B* / P33176* / kinesin family member 5B*ENSDARG0000010339427
kif5ba / kinesin family member 5B, a / KIF5B* / Q61768* / P33176* / Kinesin-1 heavy chain * / kinesin family member 5B*ENSDARG0000007413127
CABZ01066312.1ENSDARG000001006242


Protein motifs (from Interpro)
Interpro ID Name
 IPR001752  Kinesin motor domain
 IPR019821  Kinesin motor domain, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0035845 photoreceptor cell outer segment organization IMP
 biological_processGO:0046907 intracellular transport IMP
 biological_processGO:0060271 cilium assembly IMP
 cellular_componentGO:0005871 kinesin complex IDA
 cellular_componentGO:0005874 microtubule IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0016887 ATPase activity IBA


Pathways (from Reactome)
Pathway description
Hedgehog off state
Intraflagellar transport
Hedgehog on state
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000076 swim bladder swim bladder physical object quality , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000130 olfactory pit olfactory pit cilium absent , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct cilium absent , abnormal
Show

 ZFA:0000151 pronephros pronephros cilium shortened , abnormal
pronephros cystic , abnormal
Show

 ZFA:0000152 retina retina central region degenerate , abnormal
retina central region lacks parts or has fewer parts of type retinal rod cell , abnormal
retina central region has fewer parts of type retinal cone cell , abnormal
retina cell death increased occurrence , abnormal
Show

 ZFA:0000166 lateral crista lateral crista cilium decreased length , abnormal
lateral crista cilium decreased amount , abnormal
Show

 ZFA:0000281 hair cell posterior macula hair cell posterior macula cilium absent , abnormal
Show

 ZFA:0000529 kidney kidney cystic , abnormal
Show

 ZFA:0000566 posterior crista posterior crista cilium decreased length , abnormal
posterior crista cilium decreased amount , abnormal
Show

 ZFA:0000619 anterior crista anterior crista cilium decreased length , abnormal
anterior crista cilium decreased amount , abnormal
Show

 ZFA:0000678 hair cell anterior macula hair cell anterior macula cilium absent , abnormal
Show

 ZFA:0000938 central canal central canal cilium absent , abnormal
Show

 ZFA:0001094 whole organism whole organism curved ventral , abnormal
whole organism curved , abnormal
whole organism increased curvature , abnormal
whole organism decreased amount , abnormal
Show

 ZFA:0001464 retinal outer nuclear layer retinal outer nuclear layer decreased thickness , abnormal
retinal outer nuclear layer absence due to degeneration , abnormal
Show

 ZFA:0001466 photoreceptor outer segment layer photoreceptor outer segment layer morphology , abnormal
photoreceptor outer segment layer decreased size , abnormal
photoreceptor outer segment layer degenerate , abnormal
Show

 ZFA:0001469 lateral line lateral line cilium absent , abnormal
Show

 ZFA:0009091 melanocyte melanocyte melanosome spatial pattern , abnormal
Show

 ZFA:0009127 photoreceptor cell photoreceptor cell photoreceptor outer segment absent , abnormal
photoreceptor cell photoreceptor outer segment displaced to photoreceptor cell lateral surface, abnormal
photoreceptor cell ciliary basal body mislocalised , abnormal
photoreceptor cell cilium absent , abnormal
photoreceptor cell photoreceptor connecting cilium absent , abnormal
photoreceptor cell ciliary basal body absent , abnormal
Show

 ZFA:0009154 eye photoreceptor cell eye photoreceptor cell photoreceptor outer segment decreased amount , abnormal
eye photoreceptor cell photoreceptor connecting cilium absent , abnormal
eye photoreceptor cell degenerate , abnormal
Show

 ZFA:0009262 retinal cone cell retinal cone cell decreased amount , abnormal
retinal cone cell decreased length , abnormal
retinal cone cell decreased distribution , abnormal
retinal cone cell non-functional , abnormal
Show

 ZFA:0009275 retinal rod cell retinal rod cell decreased amount , abnormal
retinal rod cell structure , abnormal
retinal rod cell photoreceptor outer segment absent , abnormal
retinal rod cell photoreceptor inner segment mislocalised , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000006862 kifap3b / kinesin-associated protein 3b / Q92845* / KIFAP3* / P70188* / kinesin associated protein 3*  / complex
 ENSDARG00000087538 kif3a / kinesin family member 3A / P28741* / Q9Y496* / Kinesin-like protein KIF3A *  / reaction / complex
 ENSDARG00000011545 arrb2b / arrestin, beta 2b / ARRB2* / Q91YI4* / P32121* / arrestin beta 2* / Beta-arrestin-2 *  / complex
 ENSDARG00000101120 kif3b / kinesin family member 3B / O15066* / Q61771* / Kinesin-like protein KIF3B Kinesin-like protein KIF3B, N-terminally processed*  / complex
 ENSDARG00000079500 kif3cb / kinesin family member 3Cb / KIF3C* / O14782* / O35066* / kinesin family member 3C* / Kinesin-like protein KIF3C *  / complex
 ENSDARG00000043241 arrb1 / arrestin, beta 1 / P49407*  / complex
 ENSDARG00000002952 smo / smoothened, frizzled class receptor / P56726* / Q99835*  / complex
 ENSDARG00000039215 arrb2a / arrestin, beta 2a / ARRB2* / Q91YI4* / P32121* / arrestin beta 2* / Beta-arrestin-2 *  / complex
 ENSDARG00000017162 kif3ca / kinesin family member 3Ca / KIF3C* / O14782* / kinesin family member 3C*  / complex
 ENSDARG00000040556 ift20 / intraflagellar transport 20 homolog (Chlamydomonas) / Q8IY31* / Q61025* / Intraflagellar transport * / intraflagellar transport 20*  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr