ENSDARG00000087538


Danio rerio

Features
Gene ID: ENSDARG00000087538
  
Biological name :kif3a
  
Synonyms : kif3a / kinesin family member 3A
  
Possible biological names infered from orthology : Kinesin-like protein KIF3A / P28741 / Q9Y496
  
Species: Danio rerio
  
Chr. number: 14
Strand: 1
Band:
Gene start: 23970818
Gene end: 23999566
  
Corresponding Affymetrix probe sets: Dr.3264.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000107221
Ensembl peptide - ENSDARP00000106255
NCBI entrez gene - 550267     See in Manteia.
RefSeq - NM_001017604
RefSeq Peptide - NP_001017604
swissprot - E9QB71
swissprot - Q568I3
ZFIN ID - ZDB-GENE-050417-71
Ensembl - ENSDARG00000087538
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KIF3AENSGALG00000006860Gallus gallus
 KIF3AENSG00000131437Homo sapiens
 Kif3aENSMUSG00000018395Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
kif3b / kinesin family member 3B / O15066* / Q61771* / Kinesin-like protein KIF3B Kinesin-like protein KIF3B, N-terminally processed*ENSDARG0000010112049
kif3ca / kinesin family member 3Ca / KIF3C* / O14782* / kinesin family member 3C*ENSDARG0000001716245
kif3cb / kinesin family member 3Cb / KIF3C* / O14782* / O35066* / kinesin family member 3C* / Kinesin-like protein KIF3C *ENSDARG0000007950044
kif17 / kinesin family member 17 / Q99PW8* / Q9P2E2* / Kinesin-like protein KIF17 *ENSDARG0000005523841
kif11 / kinesin family member 11 / P52732* / Q6P9P6* / Kinesin-like protein KIF11 *ENSDARG0000001094831
kif15 / kinesin family member 15 / Q6P9L6* / Q9NS87* / Kinesin-like protein KIF15 *ENSDARG0000001207330
kif4 / kinesin family member 4 / KIF4A* / KIF4B* / Q2VIQ3* / O95239* / P33174* / kinesin family member 4A* / kinesin family member 4B* / Chromosome-associated kinesin KIF4 *ENSDARG0000000546230
kif5aa / kinesin family member 5A, a / KIF5A* / Q12840* / kinesin family member 5A*ENSDARG0000009893630
kif21a / kinesin family member 21A / Q7Z4S6* / Q9QXL2* / Kinesin-like protein KIF21A *ENSDARG0000006113130
kif5c / kinesin family member 5C / O60282* / P28738* / Kinesin heavy chain isoform 5C *ENSDARG0000007602729
kif7 / kinesin family member 7 / Q2M1P5*ENSDARG0000003309929
cenpe / centromere protein E / Q02224*ENSDARG0000006338528
kif21b / kinesin family member 21B / O75037*ENSDARG0000000973328
kif5ab / kinesin family member 5A, b / KIF5A* / P33175* / Q12840* / kinesin family member 5A* / Kinesin heavy chain isoform 5A *ENSDARG0000005981827
kif5ba / kif5bb / kinesin family member 5B, b / KIF5B* / P33176* / kinesin family member 5B*ENSDARG0000010339427
kif5ba / kinesin family member 5B, a / KIF5B* / Q61768* / P33176* / Kinesin-1 heavy chain * / kinesin family member 5B*ENSDARG0000007413127
CABZ01066312.1ENSDARG000001006242


Protein motifs (from Interpro)
Interpro ID Name
 IPR001752  Kinesin motor domain
 IPR019821  Kinesin motor domain, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0035845 photoreceptor cell outer segment organization IMP
 biological_processGO:0046907 intracellular transport IMP
 biological_processGO:0060271 cilium assembly IMP
 cellular_componentGO:0005871 kinesin complex IDA
 cellular_componentGO:0005874 microtubule IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0016887 ATPase activity IBA


Pathways (from Reactome)
Pathway description
Hedgehog off state
Intraflagellar transport
Hedgehog on state
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000076 swim bladder swim bladder physical object quality , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000130 olfactory pit olfactory pit cilium absent , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct cilium absent , abnormal
Show

 ZFA:0000151 pronephros pronephros cilium shortened , abnormal
pronephros cystic , abnormal
Show

 ZFA:0000152 retina retina central region degenerate , abnormal
retina central region lacks parts or has fewer parts of type retinal rod cell , abnormal
retina central region has fewer parts of type retinal cone cell , abnormal
retina cell death increased occurrence , abnormal
Show

 ZFA:0000166 lateral crista lateral crista cilium decreased length , abnormal
lateral crista cilium decreased amount , abnormal
Show

 ZFA:0000281 hair cell posterior macula hair cell posterior macula cilium absent , abnormal
Show

 ZFA:0000529 kidney kidney cystic , abnormal
Show

 ZFA:0000566 posterior crista posterior crista cilium decreased length , abnormal
posterior crista cilium decreased amount , abnormal
Show

 ZFA:0000619 anterior crista anterior crista cilium decreased length , abnormal
anterior crista cilium decreased amount , abnormal
Show

 ZFA:0000678 hair cell anterior macula hair cell anterior macula cilium absent , abnormal
Show

 ZFA:0000938 central canal central canal cilium absent , abnormal
Show

 ZFA:0001094 whole organism whole organism curved ventral , abnormal
whole organism curved , abnormal
whole organism increased curvature , abnormal
whole organism decreased amount , abnormal
Show

 ZFA:0001464 retinal outer nuclear layer retinal outer nuclear layer decreased thickness , abnormal
retinal outer nuclear layer absence due to degeneration , abnormal
Show

 ZFA:0001466 photoreceptor outer segment layer photoreceptor outer segment layer morphology , abnormal
photoreceptor outer segment layer decreased size , abnormal
photoreceptor outer segment layer degenerate , abnormal
Show

 ZFA:0001469 lateral line lateral line cilium absent , abnormal
Show

 ZFA:0009091 melanocyte melanocyte melanosome spatial pattern , abnormal
Show

 ZFA:0009127 photoreceptor cell photoreceptor cell photoreceptor outer segment absent , abnormal
photoreceptor cell photoreceptor outer segment displaced to photoreceptor cell lateral surface, abnormal
photoreceptor cell ciliary basal body mislocalised , abnormal
photoreceptor cell cilium absent , abnormal
photoreceptor cell photoreceptor connecting cilium absent , abnormal
photoreceptor cell ciliary basal body absent , abnormal
Show

 ZFA:0009154 eye photoreceptor cell eye photoreceptor cell photoreceptor outer segment decreased amount , abnormal
eye photoreceptor cell photoreceptor connecting cilium absent , abnormal
eye photoreceptor cell degenerate , abnormal
Show

 ZFA:0009262 retinal cone cell retinal cone cell decreased amount , abnormal
retinal cone cell decreased length , abnormal
retinal cone cell decreased distribution , abnormal
retinal cone cell non-functional , abnormal
Show

 ZFA:0009275 retinal rod cell retinal rod cell decreased amount , abnormal
retinal rod cell structure , abnormal
retinal rod cell photoreceptor outer segment absent , abnormal
retinal rod cell photoreceptor inner segment mislocalised , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000006862 kifap3b / kinesin-associated protein 3b / Q92845* / KIFAP3* / P70188* / kinesin associated protein 3*  / complex
 ENSDARG00000087538 kif3a / kinesin family member 3A / P28741* / Q9Y496* / Kinesin-like protein KIF3A *  / reaction / complex
 ENSDARG00000011545 arrb2b / arrestin, beta 2b / ARRB2* / Q91YI4* / P32121* / arrestin beta 2* / Beta-arrestin-2 *  / complex
 ENSDARG00000101120 kif3b / kinesin family member 3B / O15066* / Q61771* / Kinesin-like protein KIF3B Kinesin-like protein KIF3B, N-terminally processed*  / complex
 ENSDARG00000079500 kif3cb / kinesin family member 3Cb / KIF3C* / O14782* / O35066* / kinesin family member 3C* / Kinesin-like protein KIF3C *  / complex
 ENSDARG00000043241 arrb1 / arrestin, beta 1 / P49407*  / complex
 ENSDARG00000002952 smo / smoothened, frizzled class receptor / P56726* / Q99835*  / complex
 ENSDARG00000039215 arrb2a / arrestin, beta 2a / ARRB2* / Q91YI4* / P32121* / arrestin beta 2* / Beta-arrestin-2 *  / complex
 ENSDARG00000017162 kif3ca / kinesin family member 3Ca / KIF3C* / O14782* / kinesin family member 3C*  / complex
 ENSDARG00000040556 ift20 / intraflagellar transport 20 homolog (Chlamydomonas) / Q8IY31* / Q61025* / Intraflagellar transport * / intraflagellar transport 20*  / complex






 

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