ENSDARG00000002952


Danio rerio

Features
Gene ID: ENSDARG00000002952
  
Biological name :smo
  
Synonyms : smo / smoothened, frizzled class receptor
  
Possible biological names infered from orthology : P56726 / Q99835
  
Species: Danio rerio
  
Chr. number: 4
Strand: 1
Band:
Gene start: 14971239
Gene end: 14979937
  
Corresponding Affymetrix probe sets: Dr.24766.1.S1_at (Zebrafish Array)   Dr.4416.2.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000013486
NCBI entrez gene - 30225     See in Manteia.
swissprot - Q5RH73
ZFIN ID - ZDB-GENE-980526-89
Ensembl - ENSDARG00000002952
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SMOENSGALG00000036114Gallus gallus
 SMOENSG00000128602Homo sapiens
 SmoENSMUSG00000001761Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fzd3b / frizzled class receptor 3bENSDARG0000005869217
fzd3a / frizzled class receptor 3a / FZD3* / Q61086* / Q9NPG1* / Frizzled-3 * / frizzled class receptor 3*ENSDARG0000002166417
fzd8a / frizzled class receptor 8a / FZD8* / Q61091* / Q9H461* / Frizzled-8 * / frizzled class receptor 8*ENSDARG0000004544417
fzd7b / frizzled class receptor 7b / FZD7* / O75084* / Q61090* / Frizzled-7 * / frizzled class receptor 7*ENSDARG0000002758916
fzd9a / frizzled class receptor 9a / FZD9* / O00144* / Q9R216* / Frizzled-9 * / frizzled class receptor 9*ENSDARG0000003518516
fzd10 / frizzled class receptor 10 / Q8BKG4* / Q9ULW2* / Frizzled-10 *ENSDARG0000006821316
fzd8b / frizzled class receptor 8b / FZD8* / Q61091* / Q9H461* / Frizzled-8 * / frizzled class receptor 8*ENSDARG0000003856916
fzd1 / frizzled class receptor 1 / Q9UP38*ENSDARG0000010606216
fzd5 / frizzled class receptor 5 / Q13467* / Q9EQD0* / Frizzled-5 *ENSDARG0000002542016
fzd7a / frizzled class receptor 7a / FZD7* / O75084* / Q61090* / Frizzled-7 * / frizzled class receptor 7*ENSDARG0000006000416
fzd9b / frizzled class receptor 9b / FZD9* / O00144* / Q9R216* / Frizzled-9 * / frizzled class receptor 9*ENSDARG0000001467316
CABZ01088508.1 / FZD6* / O60353* / frizzled class receptor 6*ENSDARG0000010487415
fzd2 / frizzled class receptor 2 / Q14332* / Q9JIP6* / Frizzled-2 *ENSDARG0000005443815
sfrp1a / secreted frizzled-related protein 1a / SFRP1* / Q8C4U3* / Q8N474* / secreted frizzled related protein 1*ENSDARG000000355217
sfrp5 / secreted frizzled-related protein 5 / Q5T4F7* / secreted frizzled-related sequence protein 5*ENSDARG000000390417
sfrp1b / secreted frizzled-related protein 1b / SFRP1* / Q8C4U3* / Q8N474* / secreted frizzled related protein 1*ENSDARG000000576787
CZQB01095947.1ENSDARG000000895636
sfrp2 / secreted frizzled-related protein 2 / P97299* / Q96HF1*ENSDARG000000700506
frzb / frizzled related protein / P97401* / Q92765* / Secreted frizzled-related protein 3 *ENSDARG000000183835
FP102169.1ENSDARG000001109675


Protein motifs (from Interpro)
Interpro ID Name
 IPR000539  Frizzled/Smoothened, transmembrane domain
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR017981  GPCR, family 2-like
 IPR020067  Frizzled domain
 IPR026544  Smoothened
 IPR035683  Smoothened, transmembrane domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001839 neural plate morphogenesis IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003231 cardiac ventricle development IMP
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0007517 muscle organ development IMP
 biological_processGO:0009880 embryonic pattern specification IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0010002 cardioblast differentiation IMP
 biological_processGO:0014003 oligodendrocyte development IMP
 biological_processGO:0014033 neural crest cell differentiation IMP
 biological_processGO:0021508 floor plate formation IGI
 biological_processGO:0021520 spinal cord motor neuron cell fate specification IMP
 biological_processGO:0021522 spinal cord motor neuron differentiation IMP
 biological_processGO:0021523 somatic motor neuron differentiation IMP
 biological_processGO:0021536 diencephalon development IGI
 biological_processGO:0021537 telencephalon development IMP
 biological_processGO:0021587 cerebellum morphogenesis IMP
 biological_processGO:0021782 glial cell development IMP
 biological_processGO:0021798 forebrain dorsal/ventral pattern formation IMP
 biological_processGO:0021984 adenohypophysis development IMP
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0030239 myofibril assembly IMP
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0030902 hindbrain development IMP
 biological_processGO:0031016 pancreas development IMP
 biological_processGO:0031017 exocrine pancreas development IMP
 biological_processGO:0031018 endocrine pancreas development IMP
 biological_processGO:0031076 embryonic camera-type eye development IDA
 biological_processGO:0031290 retinal ganglion cell axon guidance IMP
 biological_processGO:0032474 otolith morphogenesis IMP
 biological_processGO:0035143 caudal fin morphogenesis IMP
 biological_processGO:0035270 endocrine system development IMP
 biological_processGO:0035479 angioblast cell migration from lateral mesoderm to midline IMP
 biological_processGO:0035912 dorsal aorta morphogenesis IMP
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0042693 muscle cell fate commitment IMP
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IMP
 biological_processGO:0048557 embryonic digestive tract morphogenesis IMP
 biological_processGO:0048663 neuron fate commitment IMP
 biological_processGO:0048702 embryonic neurocranium morphogenesis IMP
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0048741 skeletal muscle fiber development IMP
 biological_processGO:0048745 smooth muscle tissue development IMP
 biological_processGO:0048752 semicircular canal morphogenesis IMP
 biological_processGO:0048794 swim bladder development IMP
 biological_processGO:0048795 swim bladder morphogenesis IMP
 biological_processGO:0048839 inner ear development IMP
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0055002 striated muscle cell development IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060830 ciliary receptor clustering involved in smoothened signaling pathway IMP
 biological_processGO:0060844 arterial endothelial cell fate commitment IMP
 biological_processGO:0060896 neural plate pattern specification IMP
 biological_processGO:0060956 endocardial cell differentiation IMP
 biological_processGO:0071679 commissural neuron axon guidance IMP
 biological_processGO:0072175 epithelial tube formation IMP
 cellular_componentGO:0005929 cilium ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0005113 patched binding IBA
 molecular_functionGO:0008142 oxysterol binding IDA
 molecular_functionGO:0017147 Wnt-protein binding IBA


Pathways (from Reactome)
Pathway description
Hedgehog off state
BBSome-mediated cargo-targeting to cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000003 adaxial cell adaxial cell decreased amount , abnormal
Show

 ZFA:0000008 brain brain quality , abnormal
brain decreased amount , abnormal
brain hydrocephalic , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle cardiac muscle cell decreased amount , abnormal
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 ZFA:0000022 floor plate floor plate quality , abnormal
Show

 ZFA:0000028 heart primordium heart primordium cardiac muscle myoblast decreased amount , abnormal
heart primordium mesodermal cell decreased amount , abnormal
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 ZFA:0000029 hindbrain hindbrain dorso-lateral region decreased distribution , abnormal
hindbrain axial region decreased amount , abnormal
hindbrain anterior/posterior pattern specification disrupted , abnormal
hindbrain radial glial cell morphology , abnormal
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 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary physical object quality , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000059 postoptic commissure postoptic commissure absent , abnormal
postoptic commissure morphology , abnormal
postoptic commissure astrocyte mislocalised , abnormal
Show

 ZFA:0000066 proctodeum proctodeum malformed , abnormal
proctodeum atretic , abnormal
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 ZFA:0000075 spinal cord spinal cord molecular quality , abnormal
spinal cord lacks all parts of type oligodendrocyte , abnormal
spinal cord physical object quality , abnormal
spinal cord ventral region absent , abnormal
spinal cord motor neuron decreased amount , abnormal
spinal cord morphology , abnormal
spinal cord ventral region spatial pattern , ameliorated
spinal cord lacks all parts of type ventricular zone radial glial cell, abnormal
spinal cord glial cell (sensu Vertebrata) mislocalised , abnormal
spinal cord anterior region has fewer parts of type primary motor neuron , abnormal
spinal cord curved , abnormal
Show

 ZFA:0000076 swim bladder swim bladder physical object quality , abnormal
swim bladder aplastic , abnormal
swim bladder disorganized , abnormal
Show

 ZFA:0000084 yolk yolk grey , abnormal
yolk swollen , abnormal
yolk morphology , abnormal
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 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
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 ZFA:0000100 cerebellum cerebellum physical object quality , abnormal
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 ZFA:0000101 diencephalon diencephalon ventral region decreased distribution , abnormal
diencephalon ventral region decreased amount , abnormal
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 ZFA:0000107 eye eye fused with eye , abnormal
eye decreased distance eye , abnormal
eye decreased size , abnormal
eye morphology , abnormal
eye quality , abnormal
eye lens deformed , abnormal
eye adjacent to eye , abnormal
eye proliferative region increased size , abnormal
eye proliferative region mislocalised , abnormal
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 ZFA:0000109 forebrain forebrain physical object quality , abnormal
forebrain quality , abnormal
forebrain axon guidance process quality , abnormal
Show

 ZFA:0000114 heart heart decreased size , abnormal
heart malformed , abnormal
heart cardiac muscle cell decreased amount , abnormal
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 ZFA:0000123 liver liver morphology , abnormal
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 ZFA:0000128 midbrain midbrain quality , abnormal
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 ZFA:0000137 optic stalk optic stalk physical object quality , abnormal
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 ZFA:0000140 pancreas pancreas morphology , abnormal
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 ZFA:0000155 somite somite U-shaped , abnormal
somite morphology , abnormal
somite lacks all parts of type horizontal myoseptum , abnormal
somite shape , abnormal
somite absent , abnormal
somite has extra parts of type muscle precursor cell , abnormal
somite disorganized , abnormal
somite quality , abnormal
somite decreased amount , abnormal
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 ZFA:0000164 ventral mesenchyme ventral mesenchyme physical object quality , abnormal
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 ZFA:0000168 anterior macula anterior macula increased size , abnormal
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 ZFA:0000184 cleithrum cleithrum hypoplastic , abnormal
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 ZFA:0000186 common cardinal vein common cardinal vein increased width , abnormal
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 ZFA:0000217 inner ear inner ear decreased size , abnormal
inner ear wholly anterioralized , abnormal
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 ZFA:0000254 pancreas primordium pancreas primordium hypoplastic , abnormal
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 ZFA:0000279 segmental plate segmental plate anterior region lacks all parts of type adaxial cell , abnormal
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 ZFA:0000282 sensory system sensory system quality , abnormal
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 ZFA:0000292 surface structure surface structure quality , abnormal
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 ZFA:0000320 caudal commissure caudal commissure absent , abnormal
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 ZFA:0000386 macula macula fused with macula , abnormal
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 ZFA:0000396 nervous system nervous system quality , abnormal
nervous system apoptotic , abnormal
Show

 ZFA:0000435 cranial nerve II cranial nerve II commissural neuron axon guidance disrupted , abnormal
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 ZFA:0000447 tela chorioidea tela chorioidea morphology , abnormal
tela chorioidea decreased size , abnormal
tela chorioidea hypoplastic , abnormal
tela chorioidea cell decreased amount , abnormal
tela chorioidea cell fragility , abnormal
Show

 ZFA:0000458 ventral thalamus ventral thalamus decreased size , abnormal
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 ZFA:0000471 atrium atrium cardiac muscle cell decreased amount , abnormal
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 ZFA:0000530 lapillus lapillus decreased size , abnormal
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 ZFA:0000556 optic chiasm optic chiasm malformed , abnormal
optic chiasm absent , abnormal
Show

 ZFA:0000558 posterior macula posterior macula aplastic , abnormal
Show

 ZFA:0000676 sagitta sagitta decreased size , abnormal
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 ZFA:0000690 supraoptic commissure supraoptic commissure physical object quality , abnormal
Show

 ZFA:0001056 myotome myotome morphology , abnormal
myotome decreased distribution , abnormal
Show

 ZFA:0001058 caudal fin caudal fin melanocyte mislocalised , abnormal
caudal fin curved ventral , abnormal
caudal fin lacks all parts of type primary motor neuron , abnormal
Show

 ZFA:0001086 muscle pioneer muscle pioneer absent , abnormal
muscle pioneer decreased amount , abnormal
Show

 ZFA:0001089 myoseptum myoseptum broken , abnormal
myoseptum quality , abnormal
Show

 ZFA:0001094 whole organism whole organism curved , abnormal
whole organism absent , abnormal
whole organism viability , abnormal
whole organism curved ventral , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism decreased thickness , abnormal
whole organism quality , abnormal
whole organism shape , abnormal
whole organism anterior-posterior axis curved ventral , abnormal
Show

 ZFA:0001108 anterior commissure anterior commissure absent , abnormal
anterior commissure morphology , abnormal
anterior commissure astrocyte mislocalised , abnormal
anterior commissure physical object quality , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0001115 trunk trunk decreased thickness , abnormal
trunk posterior region lacks all parts of type primary motor neuron , abnormal
trunk curved ventral , abnormal
trunk curved , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
post-vent region quality , abnormal
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 ZFA:0001135 neural tube neural tube absent , abnormal
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 ZFA:0001161 pectoral fin pectoral fin aplastic , abnormal
pectoral fin quality , abnormal
pectoral fin decreased size , abnormal
pectoral fin hypoplastic , abnormal
Show

 ZFA:0001177 roof plate spinal cord region roof plate spinal cord region cell projection decreased length , abnormal
Show

 ZFA:0001198 adenohypophyseal placode adenohypophyseal placode transformed to lens , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton aplastic , abnormal
mandibular arch skeleton absent , abnormal
Show

 ZFA:0001256 lateral floor plate lateral floor plate aplastic , abnormal
lateral floor plate absent , abnormal
Show

 ZFA:0001257 medial floor plate medial floor plate broken , abnormal
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 ZFA:0001261 ventricular system ventricular system apoptotic , abnormal
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 ZFA:0001338 intestine intestine epithelial tube morphogenesis disrupted , abnormal
intestine anatomical space trabecular , abnormal
intestine anatomical space increased amount , abnormal
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 ZFA:0001458 cranial cartilage cranial cartilage absent , abnormal
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 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 aplastic , abnormal
Show

 ZFA:0001617 otolith otolith decreased size , abnormal
otolith mislocalised , abnormal
otolith non-functional , abnormal
Show

 ZFA:0005274 smooth muscle smooth muscle aplastic , abnormal
Show

 ZFA:0005409 pars superior ear pars superior ear has extra parts of type anterior crista , abnormal
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 ZFA:0007054 pillar of the anterior semicircular canal pillar of the anterior semicircular canal shape , abnormal
pillar of the anterior semicircular canal increased thickness , abnormal
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 ZFA:0009040 mesothelial cell mesothelial cell distributed , abnormal
mesothelial cell decreased amount , abnormal
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 ZFA:0009053 sensory neuron sensory neuron morphology , abnormal
sensory neuron mislocalised , abnormal
Show

 ZFA:0009084 chondrocyte chondrocyte absent , abnormal
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 ZFA:0009096 endocrine cell endocrine cell decreased amount , abnormal
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 ZFA:0009116 slow muscle cell slow muscle cell decreased size , abnormal
slow muscle cell aplastic , abnormal
slow muscle cell absent , abnormal
slow muscle cell decreased amount , abnormal
slow muscle cell morphology , abnormal
Show

 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron morphology , abnormal
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 ZFA:0009244 primary motor neuron primary motor neuron axon disorganized , abnormal
primary motor neuron decreased amount , abnormal
primary motor neuron absent , abnormal
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 ZFA:0009247 secondary motor neuron secondary motor neuron absent , abnormal
secondary motor neuron decreased amount , abnormal
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 ZFA:0009301 dopaminergic neuron dopaminergic neuron decreased amount , abnormal
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 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon guidance process quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002952 smo / smoothened, frizzled class receptor / P56726* / Q99835*  / complex
 ENSDARG00000011545 arrb2b / arrestin, beta 2b / ARRB2* / Q91YI4* / P32121* / arrestin beta 2* / Beta-arrestin-2 *  / complex
 ENSDARG00000039215 arrb2a / arrestin, beta 2a / ARRB2* / Q91YI4* / P32121* / arrestin beta 2* / Beta-arrestin-2 *  / complex
 ENSDARG00000087538 kif3a / kinesin family member 3A / P28741* / Q9Y496* / Kinesin-like protein KIF3A *  / complex
 ENSDARG00000043241 arrb1 / arrestin, beta 1 / P49407*  / complex






 

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