Manteia

ENSDARG00000025420

Danio rerio

Features

Gene ID:	ENSDARG00000025420

Biological name :	fzd5

Synonyms :	frizzled class receptor 5 / fzd5

Possible biological names infered from orthology :	Frizzled-5 / Q13467 / Q9EQD0

Species:	Danio rerio

Chr. number:	9
Strand:	1
Band:
Gene start:	28232522
Gene end:	28234444

Corresponding Affymetrix probe sets:	Dr.8066.1.S1_at (Zebrafish Array) NM_131134_at (Zebrafish Genome Array with custom cdf files)

Cross references:	Ensembl peptide - ENSDARP00000036600 NCBI entrez gene - 30364 See in Manteia. RefSeq - NM_131134 RefSeq Peptide - NP_571209 swissprot - B3DIG4 ZFIN ID - ZDB-GENE-990415-218 Ensembl - ENSDARG00000025420

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
FZD5	ENSGALG00000034101	Gallus gallus
FZD5	ENSG00000163251	Homo sapiens
Fzd5	ENSMUSG00000045005	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
fzd8a / frizzled class receptor 8a / FZD8* / Q61091* / Q9H461* / Frizzled-8 * / frizzled class receptor 8*	ENSDARG00000045444	69
fzd8b / frizzled class receptor 8b / FZD8* / Q61091* / Q9H461* / Frizzled-8 * / frizzled class receptor 8*	ENSDARG00000038569	65
fzd7b / frizzled class receptor 7b / FZD7* / O75084* / Q61090* / Frizzled-7 * / frizzled class receptor 7*	ENSDARG00000027589	45
fzd1 / frizzled class receptor 1 / Q9UP38*	ENSDARG00000106062	45
fzd7a / frizzled class receptor 7a / FZD7* / O75084* / Q61090* / Frizzled-7 * / frizzled class receptor 7*	ENSDARG00000060004	44
fzd2 / frizzled class receptor 2 / Q14332* / Q9JIP6* / Frizzled-2 *	ENSDARG00000054438	44
fzd10 / frizzled class receptor 10 / Q8BKG4* / Q9ULW2* / Frizzled-10 *	ENSDARG00000068213	40
fzd9a / frizzled class receptor 9a / FZD9* / O00144* / Q9R216* / Frizzled-9 * / frizzled class receptor 9*	ENSDARG00000035185	39
fzd9b / frizzled class receptor 9b / FZD9* / O00144* / Q9R216* / Frizzled-9 * / frizzled class receptor 9*	ENSDARG00000014673	38
fzd3b / frizzled class receptor 3b	ENSDARG00000058692	35
fzd3a / frizzled class receptor 3a / FZD3* / Q61086* / Q9NPG1* / Frizzled-3 * / frizzled class receptor 3*	ENSDARG00000021664	34
CABZ01088508.1 / FZD6* / O60353* / frizzled class receptor 6*	ENSDARG00000104874	31
smo / smoothened, frizzled class receptor / P56726* / Q99835*	ENSDARG00000002952	22
frzb / frizzled related protein / P97401* / Q92765* / Secreted frizzled-related protein 3 *	ENSDARG00000018383	14
sfrp2 / secreted frizzled-related protein 2 / P97299* / Q96HF1*	ENSDARG00000070050	13
sfrp1a / secreted frizzled-related protein 1a / SFRP1* / Q8C4U3* / Q8N474* / secreted frizzled related protein 1*	ENSDARG00000035521	13
sfrp5 / secreted frizzled-related protein 5 / Q5T4F7* / secreted frizzled-related sequence protein 5*	ENSDARG00000039041	12
CZQB01095947.1	ENSDARG00000089563	12
sfrp1b / secreted frizzled-related protein 1b / SFRP1* / Q8C4U3* / Q8N474* / secreted frizzled related protein 1*	ENSDARG00000057678	11
FP102169.1	ENSDARG00000110967	10

Protein motifs (from Interpro)

Interpro ID	Name
IPR000539	Frizzled/Smoothened, transmembrane domain
IPR015526	Frizzled/secreted frizzled-related protein
IPR017981	GPCR, family 2-like
IPR020067	Frizzled domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001889	liver development	IGI
biological_process	GO:0007166	cell surface receptor signaling pathway	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0016055	Wnt signaling pathway	IMP
biological_process	GO:0035567	non-canonical Wnt signaling pathway	IGI
biological_process	GO:0043010	camera-type eye development	IMP
biological_process	GO:0048794	swim bladder development	IMP
biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IMP
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IBA
molecular_function	GO:0004888	transmembrane signaling receptor activity	IEA
molecular_function	GO:0004930	G-protein coupled receptor activity	IBA
molecular_function	GO:0017147	Wnt-protein binding	IBA
molecular_function	GO:0042813	Wnt-activated receptor activity	IMP

Pathways (from Reactome)

Pathway description

Ca2+ pathway

Asymmetric localization of PCP proteins

Disassembly of the destruction complex and recruitment of AXIN to the membrane

Regulation of FZD by ubiquitination

WNT5A-dependent internalization of FZD2, FZD5 and ROR2

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000076	swim bladder	swim bladder decreased size , abnormal	Show
ZFA:0000107	eye	eye decreased size , abnormal eye perforate , abnormal	Show
ZFA:0000123	liver	liver decreased size , abnormal	Show
ZFA:0000570	optic primordium	optic primordium decreased size , abnormal	Show
ZFA:0001202	optic cup	optic cup increased amount , abnormal	Show
ZFA:0001284	optic fissure	optic fissure closure incomplete , abnormal	Show
ZFA:0001679	solid lens vesicle	solid lens vesicle decreased amount , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr