ENSDARG00000039041


Danio rerio

Features
Gene ID: ENSDARG00000039041
  
Biological name :sfrp5
  
Synonyms : secreted frizzled-related protein 5 / sfrp5
  
Possible biological names infered from orthology : Q5T4F7 / secreted frizzled-related sequence protein 5
  
Species: Danio rerio
  
Chr. number: 13
Strand: -1
Band:
Gene start: 39911551
Gene end: 39947335
  
Corresponding Affymetrix probe sets: Dr.21012.1.A1_at (Zebrafish Array)   Dr.21012.1.S1_at (Zebrafish Array)   NM_131858_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000056995
NCBI entrez gene - 117510     See in Manteia.
RefSeq - NM_131858
RefSeq Peptide - NP_571933
swissprot - F1QJG6
ZFIN ID - ZDB-GENE-011108-2
Ensembl - ENSDARG00000039041
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SFRP5ENSGALG00000007515Gallus gallus
 SFRP5ENSG00000120057Homo sapiens
 Sfrp5ENSMUSG00000018822Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sfrp1a / secreted frizzled-related protein 1a / SFRP1* / Q8C4U3* / Q8N474* / secreted frizzled related protein 1*ENSDARG0000003552154
sfrp1b / secreted frizzled-related protein 1b / SFRP1* / Q8C4U3* / Q8N474* / secreted frizzled related protein 1*ENSDARG0000005767852
sfrp2 / secreted frizzled-related protein 2 / P97299* / Q96HF1*ENSDARG0000007005041
FP102169.1ENSDARG0000011096734
CZQB01095947.1ENSDARG0000008956330
fzd1 / frizzled class receptor 1 / Q9UP38*ENSDARG0000010606227
szl / sizzledENSDARG0000009963726
fzd7a / frizzled class receptor 7a / FZD7* / O75084* / Q61090* / Frizzled-7 * / frizzled class receptor 7*ENSDARG0000006000425
fzd9b / frizzled class receptor 9b / FZD9* / O00144* / Q9R216* / Frizzled-9 * / frizzled class receptor 9*ENSDARG0000001467324
fzd2 / frizzled class receptor 2 / Q14332* / Q9JIP6* / Frizzled-2 *ENSDARG0000005443824
fzd8a / frizzled class receptor 8a / FZD8* / Q61091* / Q9H461* / Frizzled-8 * / frizzled class receptor 8*ENSDARG0000004544424
fzd7b / frizzled class receptor 7b / FZD7* / O75084* / Q61090* / Frizzled-7 * / frizzled class receptor 7*ENSDARG0000002758924
fzd9a / frizzled class receptor 9a / FZD9* / O00144* / Q9R216* / Frizzled-9 * / frizzled class receptor 9*ENSDARG0000003518524
fzd10 / frizzled class receptor 10 / Q8BKG4* / Q9ULW2* / Frizzled-10 *ENSDARG0000006821324
fzd8b / frizzled class receptor 8b / FZD8* / Q61091* / Q9H461* / Frizzled-8 * / frizzled class receptor 8*ENSDARG0000003856923
fzd5 / frizzled class receptor 5 / Q13467* / Q9EQD0* / Frizzled-5 *ENSDARG0000002542022
fzd3a / frizzled class receptor 3a / FZD3* / Q61086* / Q9NPG1* / Frizzled-3 * / frizzled class receptor 3*ENSDARG0000002166421
fzd3b / frizzled class receptor 3bENSDARG0000005869221
CABZ01088508.1 / FZD6* / O60353* / frizzled class receptor 6*ENSDARG0000010487420
smo / smoothened, frizzled class receptor / P56726* / Q99835*ENSDARG0000000295218


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR018933  Netrin module, non-TIMP type
 IPR020067  Frizzled domain
 IPR034860  Secreted frizzled-related protein 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001654 eye development IGI
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030111 regulation of Wnt signaling pathway IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IGI
 biological_processGO:0030510 regulation of BMP signaling pathway IEA
 biological_processGO:0030513 positive regulation of BMP signaling pathway IGI
 biological_processGO:0030900 forebrain development IDA
 biological_processGO:0035567 non-canonical Wnt signaling pathway IBA
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IGI
 biological_processGO:0060070 canonical Wnt signaling pathway IBA
 biological_processGO:0061031 endodermal digestive tract morphogenesis IMP
 biological_processGO:0061386 closure of optic fissure IGI
 biological_processGO:0072576 liver morphogenesis IMP
 biological_processGO:2000056 regulation of Wnt signaling pathway involved in digestive tract morphogenesis IGI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0017147 Wnt-protein binding IBA
 molecular_functionGO:0042813 Wnt-activated receptor activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000017 endoderm endoderm decreased size , abnormal
Show

 ZFA:0000123 liver liver decreased size , abnormal
liver disorganized , abnormal
Show

 ZFA:0000140 pancreas pancreas decreased size , abnormal
Show

 ZFA:0001338 intestine intestine decreased size , abnormal
Show

 ZFA:0009398 hepatoblast hepatoblast decreased size , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr