ENSG00000120057


Homo sapiens

Features
Gene ID: ENSG00000120057
  
Biological name :SFRP5
  
Synonyms : Q5T4F7 / secreted frizzled related protein 5 / SFRP5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q24.2
Gene start: 97766751
Gene end: 97771952
  
Corresponding Affymetrix probe sets: 207468_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000266066
NCBI entrez gene - 6425     See in Manteia.
OMIM - 604158
RefSeq - NM_003015
RefSeq Peptide - NP_003006
swissprot - Q5T4F7
Ensembl - ENSG00000120057
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sfrp5ENSDARG00000039041Danio rerio
 SFRP5ENSGALG00000007515Gallus gallus
 Sfrp5ENSMUSG00000018822Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SFRP1 / Q8N474 / secreted frizzled related protein 1ENSG0000010433255
SFRP2 / Q96HF1 / secreted frizzled related protein 2ENSG0000014542339
FZD1 / Q9UP38 / frizzled class receptor 1ENSG0000015724026
FZD7 / O75084 / frizzled class receptor 7ENSG0000015576024
FZD5 / Q13467 / frizzled class receptor 5ENSG0000016325124
FZD9 / O00144 / frizzled class receptor 9ENSG0000018876324
FZD8 / Q9H461 / frizzled class receptor 8ENSG0000017728323
FZD2 / Q14332 / frizzled class receptor 2ENSG0000018034023
FZD4 / Q9ULV1 / frizzled class receptor 4ENSG0000017480423
FZD10 / Q9ULW2 / frizzled class receptor 10ENSG0000011143223
FZD6 / O60353 / frizzled class receptor 6ENSG0000016493020
FZD3 / Q9NPG1 / frizzled class receptor 3ENSG0000010429020
SMO / Q99835 / smoothened, frizzled class receptorENSG0000012860218
FRZB / Q92765 / frizzled related proteinENSG0000016299817
SFRP4 / Q6FHJ7 / secreted frizzled related protein 4ENSG0000010648316


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR018933  Netrin module, non-TIMP type
 IPR020067  Frizzled domain
 IPR034860  Secreted frizzled-related protein 5
 IPR036790  Frizzled cysteine-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0007163 establishment or maintenance of cell polarity TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007601 visual perception TAS
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030111 regulation of Wnt signaling pathway IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway NAS
 biological_processGO:0030510 regulation of BMP signaling pathway IEA
 biological_processGO:0035567 non-canonical Wnt signaling pathway IBA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0051898 negative regulation of protein kinase B signaling IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 biological_processGO:2000057 negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0016021 integral component of membrane IBA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017147 Wnt-protein binding IBA
 molecular_functionGO:0042813 Wnt-activated receptor activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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