ENSG00000177283


Homo sapiens

Features
Gene ID: ENSG00000177283
  
Biological name :FZD8
  
Synonyms : frizzled class receptor 8 / FZD8 / Q9H461
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: p11.21
Gene start: 35638249
Gene end: 35642278
  
Corresponding Affymetrix probe sets: 216587_s_at (Human Genome U133 Plus 2.0 Array)   224325_at (Human Genome U133 Plus 2.0 Array)   227405_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000363826
NCBI entrez gene - 8325     See in Manteia.
OMIM - 606146
RefSeq - NM_031866
RefSeq Peptide - NP_114072
swissprot - Q9H461
Ensembl - ENSG00000177283
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fzd8aENSDARG00000045444Danio rerio
 fzd8bENSDARG00000038569Danio rerio
 FZD8ENSGALG00000039999Gallus gallus
 Fzd8ENSMUSG00000036904Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FZD5 / Q13467 / frizzled class receptor 5ENSG0000016325159
FZD2 / Q14332 / frizzled class receptor 2ENSG0000018034041
FZD1 / Q9UP38 / frizzled class receptor 1ENSG0000015724040
FZD7 / O75084 / frizzled class receptor 7ENSG0000015576039
FZD10 / Q9ULW2 / frizzled class receptor 10ENSG0000011143237
FZD9 / O00144 / frizzled class receptor 9ENSG0000018876335
FZD4 / Q9ULV1 / frizzled class receptor 4ENSG0000017480433
FZD6 / O60353 / frizzled class receptor 6ENSG0000016493029
FZD3 / Q9NPG1 / frizzled class receptor 3ENSG0000010429029
SMO / Q99835 / smoothened, frizzled class receptorENSG0000012860222
FRZB / Q92765 / frizzled related proteinENSG0000016299813
SFRP4 / Q6FHJ7 / secreted frizzled related protein 4ENSG0000010648313
SFRP5 / Q5T4F7 / secreted frizzled related protein 5ENSG0000012005711
SFRP2 / Q96HF1 / secreted frizzled related protein 2ENSG0000014542311
SFRP1 / Q8N474 / secreted frizzled related protein 1ENSG0000010433210


Protein motifs (from Interpro)
Interpro ID Name
 IPR000539  Frizzled/Smoothened, transmembrane domain
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR017981  GPCR, family 2-like
 IPR020067  Frizzled domain
 IPR036790  Frizzled cysteine-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030182 neuron differentiation ISS
 biological_processGO:0033077 T cell differentiation in thymus IEA
 biological_processGO:0035567 non-canonical Wnt signaling pathway IBA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IMP
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 cellular_componentGO:1990851 Wnt-Frizzled-LRP5/6 complex IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017147 Wnt-protein binding IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042813 Wnt-activated receptor activity IEA


Pathways (from Reactome)
Pathway description
Class B/2 (Secretin family receptors)
Asymmetric localization of PCP proteins
Regulation of FZD by ubiquitination
RNF mutants show enhanced WNT signaling and proliferation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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