ENSG00000104332


Homo sapiens

Features
Gene ID: ENSG00000104332
  
Biological name :SFRP1
  
Synonyms : Q8N474 / secreted frizzled related protein 1 / SFRP1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p11.21
Gene start: 41261958
Gene end: 41309497
  
Corresponding Affymetrix probe sets: 202035_s_at (Human Genome U133 Plus 2.0 Array)   202036_s_at (Human Genome U133 Plus 2.0 Array)   202037_s_at (Human Genome U133 Plus 2.0 Array)   228413_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000220772
Ensembl peptide - ENSP00000369174
NCBI entrez gene - 6422     See in Manteia.
OMIM - 604156
RefSeq - NM_003012
RefSeq Peptide - NP_003003
swissprot - Q6ZSL4
swissprot - Q8N474
Ensembl - ENSG00000104332
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sfrp1aENSDARG00000035521Danio rerio
 sfrp1bENSDARG00000057678Danio rerio
 SFRP1ENSGALG00000003473Gallus gallus
 Sfrp1ENSMUSG00000031548Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SFRP5 / Q5T4F7 / secreted frizzled related protein 5ENSG0000012005756
SFRP2 / Q96HF1 / secreted frizzled related protein 2ENSG0000014542338
FZD1 / Q9UP38 / frizzled class receptor 1ENSG0000015724028
FZD7 / O75084 / frizzled class receptor 7ENSG0000015576027
FZD4 / Q9ULV1 / frizzled class receptor 4ENSG0000017480426
FZD10 / Q9ULW2 / frizzled class receptor 10ENSG0000011143224
FZD2 / Q14332 / frizzled class receptor 2ENSG0000018034024
FZD5 / Q13467 / frizzled class receptor 5ENSG0000016325124
FZD9 / O00144 / frizzled class receptor 9ENSG0000018876323
FZD8 / Q9H461 / frizzled class receptor 8ENSG0000017728323
FZD3 / Q9NPG1 / frizzled class receptor 3ENSG0000010429021
FZD6 / O60353 / frizzled class receptor 6ENSG0000016493020
SMO / Q99835 / smoothened, frizzled class receptorENSG0000012860220
FRZB / Q92765 / frizzled related proteinENSG0000016299817
SFRP4 / Q6FHJ7 / secreted frizzled related protein 4ENSG0000010648317


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR018933  Netrin module, non-TIMP type
 IPR020067  Frizzled domain
 IPR026559  Secreted frizzled-related protein 1
 IPR036790  Frizzled cysteine-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IEP
 biological_processGO:0001657 ureteric bud development IEA
 biological_processGO:0001756 somitogenesis IEA
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0001954 positive regulation of cell-matrix adhesion ISS
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IDA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0008585 female gonad development IEA
 biological_processGO:0009267 cellular response to starvation IEP
 biological_processGO:0009950 dorsal/ventral axis specification IDA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0010564 regulation of cell cycle process IMP
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IDA
 biological_processGO:0010975 regulation of neuron projection development IEA
 biological_processGO:0014034 neural crest cell fate commitment IEA
 biological_processGO:0014070 response to organic cyclic compound IDA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0021915 neural tube development IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IDA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IEA
 biological_processGO:0030279 negative regulation of ossification IEA
 biological_processGO:0030307 positive regulation of cell growth IDA
 biological_processGO:0030308 negative regulation of cell growth IDA
 biological_processGO:0030336 negative regulation of cell migration IDA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 biological_processGO:0033689 negative regulation of osteoblast proliferation IEA
 biological_processGO:0035019 somatic stem cell population maintenance IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043508 negative regulation of JUN kinase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity ISS
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IDA
 biological_processGO:0044345 stromal-epithelial cell signaling involved in prostate gland development IEA
 biological_processGO:0045578 negative regulation of B cell differentiation IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation IDA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0045671 negative regulation of osteoclast differentiation IEA
 biological_processGO:0045765 regulation of angiogenesis ISS
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0046546 development of primary male sexual characteristics IEA
 biological_processGO:0046676 negative regulation of insulin secretion IDA
 biological_processGO:0046851 negative regulation of bone remodeling IMP
 biological_processGO:0048147 negative regulation of fibroblast proliferation IDA
 biological_processGO:0048546 digestive tract morphogenesis IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IMP
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IDA
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0051496 positive regulation of stress fiber assembly ISS
 biological_processGO:0051894 positive regulation of focal adhesion assembly ISS
 biological_processGO:0060070 canonical Wnt signaling pathway IDA
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway IEA
 biological_processGO:0060218 hematopoietic stem cell differentiation IDA
 biological_processGO:0060346 bone trabecula formation IEA
 biological_processGO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IEA
 biological_processGO:0060687 regulation of branching involved in prostate gland morphogenesis IEA
 biological_processGO:0060766 negative regulation of androgen receptor signaling pathway IDA
 biological_processGO:0071305 cellular response to vitamin D IEP
 biological_processGO:0071347 cellular response to interleukin-1 IEP
 biological_processGO:0071356 cellular response to tumor necrosis factor IDA
 biological_processGO:0071363 cellular response to growth factor stimulus IDA
 biological_processGO:0071380 cellular response to prostaglandin E stimulus IEP
 biological_processGO:0071391 cellular response to estrogen stimulus IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEP
 biological_processGO:0071456 cellular response to hypoxia IEP
 biological_processGO:0071481 cellular response to X-ray IEA
 biological_processGO:0071504 cellular response to heparin IDA
 biological_processGO:0071542 dopaminergic neuron differentiation IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEP
 biological_processGO:0071773 cellular response to BMP stimulus IEP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090175 regulation of establishment of planar polarity IEA
 biological_processGO:0090179 planar cell polarity pathway involved in neural tube closure IEA
 biological_processGO:0090244 Wnt signaling pathway involved in somitogenesis IEA
 biological_processGO:0090246 convergent extension involved in somitogenesis IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IGI
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
 biological_processGO:1904956 regulation of midbrain dopaminergic neuron differentiation IEA
 biological_processGO:2000041 negative regulation of planar cell polarity pathway involved in axis elongation IEA
 biological_processGO:2000052 positive regulation of non-canonical Wnt signaling pathway IDA
 biological_processGO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification IDA
 biological_processGO:2000080 negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation IDA
 biological_processGO:2000270 negative regulation of fibroblast apoptotic process IDA
 biological_processGO:2000271 positive regulation of fibroblast apoptotic process IDA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IMP
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0005109 frizzled binding IPI
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008144 drug binding IDA
 molecular_functionGO:0008201 heparin binding IDA
 molecular_functionGO:0017147 Wnt-protein binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042813 Wnt-activated receptor activity IBA


Pathways (from Reactome)
Pathway description
TCF dependent signaling in response to WNT
Negative regulation of TCF-dependent signaling by WNT ligand antagonists


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000154342 WNT3A / P56704 / Wnt family member 3A  / complex / reaction






 

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