ENSGALG00000003473


Gallus gallus

Features
Gene ID: ENSGALG00000003473
  
Biological name :SFRP1
  
Synonyms : secreted frizzled related protein 1 / SFRP1
  
Possible biological names infered from orthology : Q8C4U3 / Q8N474
  
Species: Gallus gallus
  
Chr. number: 22
Strand: -1
Band:
Gene start: 2593802
Gene end: 2604692
  
Corresponding Affymetrix probe sets: Gga.4830.1.S1_at (Chicken Array)   Gga.4830.1.S2_at (Chicken Array)   GgaAffx.12350.1.A1_at (Chicken Array)   GgaAffx.12350.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000005489
Ensembl peptide - ENSGALP00000060914
Ensembl peptide - ENSGALP00000055383
NCBI entrez gene - 395237     See in Manteia.
RefSeq - NM_204553
RefSeq Peptide - NP_989884
swissprot - A0A1L1RQ37
swissprot - A0A1D5PR61
swissprot - F1NPV5
Ensembl - ENSGALG00000003473
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sfrp1aENSDARG00000035521Danio rerio
 sfrp1bENSDARG00000057678Danio rerio
 SFRP1ENSG00000104332Homo sapiens
 Sfrp1ENSMUSG00000031548Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SFRP5 / Gallus gallus secreted frizzled related protein 5 (SFRP5), mRNA. / Q5T4F7* / secreted frizzled related protein 5* / secreted frizzled-related sequence protein 5*ENSGALG0000000751550
SFRP2 / secreted frizzled-related protein 2 precursor / P97299* / Q96HF1* / secreted frizzled related protein 2*ENSGALG0000000924135
crescent precursor ENSGALG0000000694433
FZD7 / frizzled class receptor 7 / O75084* / Q61090* / Frizzled-7 *ENSGALG0000003497326
ENSGALG0000000863525
FZD2 / frizzled-2 precursor / Q9JIP6* / Q14332* / Frizzled-2 * / frizzled class receptor 2*ENSGALG0000003084724
FZD5 / frizzled class receptor 5 / Q13467* / Q9EQD0* / Frizzled-5 *ENSGALG0000003410123
FZD1 / frizzled-1 precursor / Q9UP38* / O70421* / Frizzled-1 * / frizzled class receptor 1*ENSGALG0000000906423
FZD8 / frizzled class receptor 8 / Q61091* / Q9H461* / Frizzled-8 *ENSGALG0000003999923
FZD10 / frizzled-10 precursor / Q9ULW2* / Q8BKG4* / Frizzled-10 * / frizzled class receptor 10*ENSGALG0000004200323
FZD4 / Q9IA05 / Frizzled-4 / Q61088* / Q9ULV1* / frizzled class receptor 4*ENSGALG0000001724223
FZD9 / frizzled-9 precursor / Q9R216* / O00144* / Frizzled-9 * / frizzled class receptor 9*ENSGALG0000004192722
FZD3 / frizzled class receptor 3 / Q61086* / Q9NPG1* / Frizzled-3 *ENSGALG0000004230822
FZD6 / frizzled-6 precursor / Q61089* / O60353* / Frizzled-6 * / frizzled class receptor 6*ENSGALG0000003062620
FZD10* / Q8BKG4* / Q9ULW2* / Frizzled-10 * / frizzled class receptor 10*ENSGALG0000000265220
SMO / smoothened, frizzled class receptor / P56726* / Q99835*ENSGALG0000003611419
FRZB / secreted frizzled-related protein 3 precursor / P97401* / Q92765* / frizzled related protein* / Secreted frizzled-related protein 3 *ENSGALG0000000276317
SFRP4 / secreted frizzled related protein 4 / Q6FHJ7* / Q9Z1N6*ENSGALG0000003199717


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR018933  Netrin module, non-TIMP type
 IPR020067  Frizzled domain
 IPR026559  Secreted frizzled-related protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001657 ureteric bud development IEA
 biological_processGO:0001756 somitogenesis IEA
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0008585 female gonad development IEA
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0009950 dorsal/ventral axis specification IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0010564 regulation of cell cycle process IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010975 regulation of neuron projection development IEA
 biological_processGO:0014034 neural crest cell fate commitment IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0021915 neural tube development IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IEA
 biological_processGO:0030279 negative regulation of ossification IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 biological_processGO:0033689 negative regulation of osteoblast proliferation IEA
 biological_processGO:0035019 somatic stem cell population maintenance IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043508 negative regulation of JUN kinase activity IEA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0044345 stromal-epithelial cell signaling involved in prostate gland development IEA
 biological_processGO:0045578 negative regulation of B cell differentiation IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0045671 negative regulation of osteoclast differentiation IEA
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0046546 development of primary male sexual characteristics IEA
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0046851 negative regulation of bone remodeling IEA
 biological_processGO:0048147 negative regulation of fibroblast proliferation IEA
 biological_processGO:0048546 digestive tract morphogenesis IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway IEA
 biological_processGO:0060218 hematopoietic stem cell differentiation IEA
 biological_processGO:0060346 bone trabecula formation IEA
 biological_processGO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IEA
 biological_processGO:0060687 regulation of branching involved in prostate gland morphogenesis IEA
 biological_processGO:0060766 negative regulation of androgen receptor signaling pathway IEA
 biological_processGO:0071305 cellular response to vitamin D IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0071380 cellular response to prostaglandin E stimulus IEA
 biological_processGO:0071391 cellular response to estrogen stimulus IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071481 cellular response to X-ray IEA
 biological_processGO:0071504 cellular response to heparin IEA
 biological_processGO:0071542 dopaminergic neuron differentiation IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090175 regulation of establishment of planar polarity IEA
 biological_processGO:0090179 planar cell polarity pathway involved in neural tube closure IEA
 biological_processGO:0090244 Wnt signaling pathway involved in somitogenesis IEA
 biological_processGO:0090246 convergent extension involved in somitogenesis IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:1904956 regulation of midbrain dopaminergic neuron differentiation IEA
 biological_processGO:2000041 negative regulation of planar cell polarity pathway involved in axis elongation IEA
 biological_processGO:2000052 positive regulation of non-canonical Wnt signaling pathway IEA
 biological_processGO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification IEA
 biological_processGO:2000080 negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation IEA
 biological_processGO:2000270 negative regulation of fibroblast apoptotic process IEA
 biological_processGO:2000271 positive regulation of fibroblast apoptotic process IEA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0005109 frizzled binding IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0017147 Wnt-protein binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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