ENSGALG00000036114


Gallus gallus

Features
Gene ID: ENSGALG00000036114
  
Biological name :SMO
  
Synonyms : SMO / smoothened, frizzled class receptor
  
Possible biological names infered from orthology : P56726 / Q99835
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 704038
Gene end: 711778
  
Corresponding Affymetrix probe sets: Gga.4082.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000048984
NCBI entrez gene - 395949     See in Manteia.
RefSeq - XM_015288188
swissprot - A0A1D5P8D7
Ensembl - ENSGALG00000036114
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smoENSDARG00000002952Danio rerio
 SMOENSG00000128602Homo sapiens
 SmoENSMUSG00000001761Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FZD6 / frizzled-6 precursor / Q61089* / O60353* / Frizzled-6 * / frizzled class receptor 6*ENSGALG0000003062618
FZD3 / frizzled class receptor 3 / Q61086* / Q9NPG1* / Frizzled-3 *ENSGALG0000004230818
FZD8 / frizzled class receptor 8 / Q61091* / Q9H461* / Frizzled-8 *ENSGALG0000003999917
FZD5 / frizzled class receptor 5 / Q13467* / Q9EQD0* / Frizzled-5 *ENSGALG0000003410116
FZD9 / frizzled-9 precursor / Q9R216* / O00144* / Frizzled-9 * / frizzled class receptor 9*ENSGALG0000004192716
FZD2 / frizzled-2 precursor / Q9JIP6* / Q14332* / Frizzled-2 * / frizzled class receptor 2*ENSGALG0000003084716
FZD7 / frizzled class receptor 7 / O75084* / Q61090* / Frizzled-7 *ENSGALG0000003497316
FZD1 / frizzled-1 precursor / Q9UP38* / O70421* / Frizzled-1 * / frizzled class receptor 1*ENSGALG0000000906416
FZD10 / frizzled-10 precursor / Q9ULW2* / Q8BKG4* / Frizzled-10 * / frizzled class receptor 10*ENSGALG0000004200316
FZD4 / Q9IA05 / Frizzled-4 / Q61088* / Q9ULV1* / frizzled class receptor 4*ENSGALG0000001724215
FZD10* / Q8BKG4* / Q9ULW2* / Frizzled-10 * / frizzled class receptor 10*ENSGALG0000000265215
SFRP4 / secreted frizzled related protein 4 / Q6FHJ7* / Q9Z1N6*ENSGALG000000319978
SFRP1 / secreted frizzled related protein 1 / Q8C4U3* / Q8N474*ENSGALG000000034737
SFRP5 / Gallus gallus secreted frizzled related protein 5 (SFRP5), mRNA. / Q5T4F7* / secreted frizzled related protein 5* / secreted frizzled-related sequence protein 5*ENSGALG000000075157
FRZB / secreted frizzled-related protein 3 precursor / P97401* / Q92765* / frizzled related protein* / Secreted frizzled-related protein 3 *ENSGALG000000027636
crescent precursor ENSGALG000000069446
SFRP2 / secreted frizzled-related protein 2 precursor / P97299* / Q96HF1* / secreted frizzled related protein 2*ENSGALG000000092415
ENSGALG000000086355


Protein motifs (from Interpro)
Interpro ID Name
 IPR000539  Frizzled/Smoothened, transmembrane domain
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR017981  GPCR, family 2-like
 IPR020067  Frizzled domain
 IPR026544  Smoothened


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001708 cell fate specification IEA
 biological_processGO:0001755 neural crest cell migration IEA
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0002052 positive regulation of neuroblast proliferation IEA
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IEA
 biological_processGO:0003007 heart morphogenesis IEA
 biological_processGO:0003140 determination of left/right asymmetry in lateral mesoderm IEA
 biological_processGO:0003323 type B pancreatic cell development IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007228 positive regulation of hh target transcription factor activity IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007368 determination of left/right symmetry IEA
 biological_processGO:0007371 ventral midline determination IEA
 biological_processGO:0007389 pattern specification process IEA
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0007494 midgut development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0021542 dentate gyrus development IEA
 biological_processGO:0021696 cerebellar cortex morphogenesis IEA
 biological_processGO:0021794 thalamus development IEA
 biological_processGO:0021904 dorsal/ventral neural tube patterning IEA
 biological_processGO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning IEA
 biological_processGO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation IEA
 biological_processGO:0021953 central nervous system neuron differentiation IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0030857 negative regulation of epithelial cell differentiation IEA
 biological_processGO:0031069 hair follicle morphogenesis IEA
 biological_processGO:0034504 protein localization to nucleus IEA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0040018 positive regulation of multicellular organism growth IEA
 biological_processGO:0042307 positive regulation of protein import into nucleus IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043392 negative regulation of DNA binding IEA
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046622 positive regulation of organ growth IEA
 biological_processGO:0048143 astrocyte activation IEA
 biological_processGO:0048468 cell development IEA
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0048568 embryonic organ development IEA
 biological_processGO:0048589 developmental growth IEA
 biological_processGO:0048741 skeletal muscle fiber development IEA
 biological_processGO:0048853 forebrain morphogenesis IEA
 biological_processGO:0048873 homeostasis of number of cells within a tissue IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051451 myoblast migration IEA
 biological_processGO:0051799 negative regulation of hair follicle development IEA
 biological_processGO:0060248 detection of cell density by contact stimulus involved in contact inhibition IEA
 biological_processGO:0060413 atrial septum morphogenesis IEA
 biological_processGO:0060644 mammary gland epithelial cell differentiation IEA
 biological_processGO:0060684 epithelial-mesenchymal cell signaling IEA
 biological_processGO:0061053 somite development IEA
 biological_processGO:0061113 pancreas morphogenesis IEA
 biological_processGO:0070986 left/right axis specification IEA
 biological_processGO:0071397 cellular response to cholesterol IEA
 biological_processGO:0072001 renal system development IEA
 biological_processGO:0072285 mesenchymal to epithelial transition involved in metanephric renal vesicle formation IEA
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IEA
 biological_processGO:2000036 regulation of stem cell population maintenance IEA
 biological_processGO:2000826 regulation of heart morphogenesis IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0060170 ciliary membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005113 patched binding IEA
 molecular_functionGO:0008144 drug binding IEA


Pathways (from Reactome)
Pathway description
Hedgehog off state
BBSome-mediated cargo-targeting to cilium
Hedgehog on state
Activation of SMO


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001364 P67962 / CSNK1A1 / Casein kinase I isoform alpha / Q8N752* / P48729* / Q8BK63* / CSNK1A1L* / casein kinase 1 alpha 1* / casein kinase 1 alpha 1 like*  / complex
 ENSGALG00000036114 SMO / smoothened, frizzled class receptor / P56726* / Q99835*  / complex






 

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