ENSGALG00000034101


Gallus gallus

Features
Gene ID: ENSGALG00000034101
  
Biological name :FZD5
  
Synonyms : frizzled class receptor 5 / FZD5
  
Possible biological names infered from orthology : Frizzled-5 / Q13467 / Q9EQD0
  
Species: Gallus gallus
  
Chr. number: 7
Strand: 1
Band:
Gene start: 12182572
Gene end: 12186566
  
Corresponding Affymetrix probe sets: Gga.18914.1.A1_at (Chicken Array)   Gga.18914.1.S1_at (Chicken Array)   Gga.311.1.S1_at (Chicken Array)   Gga.4.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000056684
NCBI entrez gene - 395571     See in Manteia.
RefSeq - NM_001305216
RefSeq Peptide - NP_001292145
swissprot - A0A1D5PUS8
Ensembl - ENSGALG00000034101
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fzd5ENSDARG00000025420Danio rerio
 FZD5ENSG00000163251Homo sapiens
 Fzd5ENSMUSG00000045005Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FZD8 / frizzled class receptor 8 / Q61091* / Q9H461* / Frizzled-8 *ENSGALG0000003999968
FZD1 / frizzled-1 precursor / Q9UP38* / O70421* / Frizzled-1 * / frizzled class receptor 1*ENSGALG0000000906448
FZD7 / frizzled class receptor 7 / O75084* / Q61090* / Frizzled-7 *ENSGALG0000003497348
FZD2 / frizzled-2 precursor / Q9JIP6* / Q14332* / Frizzled-2 * / frizzled class receptor 2*ENSGALG0000003084746
FZD10 / frizzled-10 precursor / Q9ULW2* / Q8BKG4* / Frizzled-10 * / frizzled class receptor 10*ENSGALG0000004200345
FZD9 / frizzled-9 precursor / Q9R216* / O00144* / Frizzled-9 * / frizzled class receptor 9*ENSGALG0000004192743
FZD10* / Q8BKG4* / Q9ULW2* / Frizzled-10 * / frizzled class receptor 10*ENSGALG0000000265243
FZD4 / Q9IA05 / Frizzled-4 / Q61088* / Q9ULV1* / frizzled class receptor 4*ENSGALG0000001724239
FZD3 / frizzled class receptor 3 / Q61086* / Q9NPG1* / Frizzled-3 *ENSGALG0000004230836
FZD6 / frizzled-6 precursor / Q61089* / O60353* / Frizzled-6 * / frizzled class receptor 6*ENSGALG0000003062634
SMO / smoothened, frizzled class receptor / P56726* / Q99835*ENSGALG0000003611422
SFRP4 / secreted frizzled related protein 4 / Q6FHJ7* / Q9Z1N6*ENSGALG0000003199715
FRZB / secreted frizzled-related protein 3 precursor / P97401* / Q92765* / frizzled related protein* / Secreted frizzled-related protein 3 *ENSGALG0000000276314
SFRP1 / secreted frizzled related protein 1 / Q8C4U3* / Q8N474*ENSGALG0000000347312
crescent precursor ENSGALG0000000694412
SFRP5 / Gallus gallus secreted frizzled related protein 5 (SFRP5), mRNA. / Q5T4F7* / secreted frizzled related protein 5* / secreted frizzled-related sequence protein 5*ENSGALG0000000751512
SFRP2 / secreted frizzled-related protein 2 precursor / P97299* / Q96HF1* / secreted frizzled related protein 2*ENSGALG0000000924112
ENSGALG0000000863510


Protein motifs (from Interpro)
Interpro ID Name
 IPR000539  Frizzled/Smoothened, transmembrane domain
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR017981  GPCR, family 2-like
 IPR020067  Frizzled domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000578 embryonic axis specification IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001944 vasculature development IEA
 biological_processGO:0002726 positive regulation of T cell cytokine production IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008595 anterior/posterior axis specification, embryo IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0031076 embryonic camera-type eye development IEA
 biological_processGO:0031077 post-embryonic camera-type eye development IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0033077 T cell differentiation in thymus IEA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048469 cell maturation IEA
 biological_processGO:0048596 embryonic camera-type eye morphogenesis IEA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IEA
 biological_processGO:0060061 Spemann organizer formation IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060561 apoptotic process involved in morphogenesis IEA
 biological_processGO:0060670 branching involved in labyrinthine layer morphogenesis IEA
 biological_processGO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development IEA
 biological_processGO:0060716 labyrinthine layer blood vessel development IEA
 biological_processGO:0060718 chorionic trophoblast cell differentiation IEA
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0071219 cellular response to molecule of bacterial origin IEA
 biological_processGO:1901382 regulation of chorionic trophoblast cell proliferation IEA
 biological_processGO:1903146 regulation of autophagy of mitochondrion IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 biological_processGO:1904469 positive regulation of tumor necrosis factor secretion IEA
 biological_processGO:2000810 regulation of bicellular tight junction assembly IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0106003 amyloid-beta complex IEA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0017147 Wnt-protein binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042813 Wnt-activated receptor activity IEA


Pathways (from Reactome)
Pathway description
Ca2+ pathway
Asymmetric localization of PCP proteins
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Regulation of FZD by ubiquitination
WNT5A-dependent internalization of FZD2, FZD5 and ROR2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000034168 WNT5A / Wnt family member 5A / P22725* / P41221* / wingless-type MMTV integration site family, member 5A*  / reaction / complex






 

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