ENSGALG00000034168


Gallus gallus

Features
Gene ID: ENSGALG00000034168
  
Biological name :WNT5A
  
Synonyms : WNT5A / Wnt family member 5A
  
Possible biological names infered from orthology : P22725 / P41221 / wingless-type MMTV integration site family, member 5A
  
Species: Gallus gallus
  
Chr. number: 12
Strand: -1
Band:
Gene start: 7906344
Gene end: 7917765
  
Corresponding Affymetrix probe sets: Gga.409.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050737
Ensembl peptide - ENSGALP00000048027
NCBI entrez gene - 395703     See in Manteia.
RefSeq - XM_015292956
RefSeq - NM_204887
RefSeq - XM_015292954
RefSeq - XM_015292955
RefSeq Peptide - NP_990218
swissprot - A0A1D5PD93
swissprot - Q9YGX6
Ensembl - ENSGALG00000034168
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnt5aENSDARG00000104973Danio rerio
 WNT5AENSG00000114251Homo sapiens
 Wnt5aENSMUSG00000021994Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WNT5B / protein Wnt-5b precursor / Q9H1J7* / P22726* / Wnt family member 5B* / wingless-type MMTV integration site family, member 5B*ENSGALG0000001299877
WNT2B / O70283* / Q93097* / Wnt family member 2B* / wingless-type MMTV integration site family, member 2B*ENSGALG0000003419647
WNT4 / P49337 / Protein Wnt-4 / P56705* / P22724* / Wnt family member 4* / wingless-type MMTV integration site family, member 4*ENSGALG0000004170844
WNT2 / Wnt family member 2 / P09544* / P21552* / wingless-type MMTV integration site family, member 2*ENSGALG0000003017343
WNT7B / Q3L254 / Protein Wnt-7b / P56706* / P28047* / Wnt family member 7B* / wingless-type MMTV integration site family, member 7B*ENSGALG0000003625542
WNT3A / Q2LMP1 / Protein Wnt-3a / P56704* / P27467* / Wnt family member 3A* / wingless-type MMTV integration site family, member 3A*ENSGALG0000004265741
WNT7A / Wnt family member 7A / O00755* / P24383* / wingless-type MMTV integration site family, member 7A*ENSGALG0000000512341
WNT3 / Wnt family member 3 / P17553* / P56703* / wingless-type MMTV integration site family, member 3*ENSGALG0000000107941
WNT11 / P49339 / Protein Wnt-11 / P48615* / O96014* / Wnt family member 11* / wingless-type MMTV integration site family, member 11*ENSGALG0000000083936
WNT6 / protein Wnt-6 / Q9Y6F9* / P22727* / Wnt family member 6* / wingless-type MMTV integration site family, member 6*ENSGALG0000001135836
WNT11BENSGALG0000000440135
WNT16 / Wnt family member 16 / Q9QYS1* / Q9UBV4* / wingless-type MMTV integration site family, member 16*ENSGALG0000002806935


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR018161  Wnt protein, conserved site
 IPR026538  Wnt-5a protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001667 ameboidal-type cell migration IEA
 biological_processGO:0001736 establishment of planar polarity IEA
 biological_processGO:0001756 somitogenesis IEA
 biological_processGO:0001819 positive regulation of cytokine production IEA
 biological_processGO:0001837 epithelial to mesenchymal transition IEA
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0002009 morphogenesis of an epithelium IEA
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IEA
 biological_processGO:0002088 lens development in camera-type eye IEP
 biological_processGO:0002741 positive regulation of cytokine secretion involved in immune response IEA
 biological_processGO:0003323 type B pancreatic cell development IEA
 biological_processGO:0003344 pericardium morphogenesis IEA
 biological_processGO:0003401 axis elongation IEA
 biological_processGO:0003402 planar cell polarity pathway involved in axis elongation IEA
 biological_processGO:0003408 optic cup formation involved in camera-type eye development IEP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway IEA
 biological_processGO:0007254 JNK cascade IEA
 biological_processGO:0007257 activation of JUN kinase activity IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007368 determination of left/right symmetry IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007442 hindgut morphogenesis IEA
 biological_processGO:0007494 midgut development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0008595 anterior/posterior axis specification, embryo IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0010820 positive regulation of T cell chemotaxis IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0021891 olfactory bulb interneuron development IEA
 biological_processGO:0021915 neural tube development IEA
 biological_processGO:0022008 neurogenesis IEA
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0030216 keratinocyte differentiation IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030326 embryonic limb morphogenesis IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 biological_processGO:0030825 obsolete positive regulation of cGMP metabolic process IEA
 biological_processGO:0030901 midbrain development IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032148 activation of protein kinase B activity IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032880 regulation of protein localization IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0035108 limb morphogenesis IEA
 biological_processGO:0035567 non-canonical Wnt signaling pathway IEA
 biological_processGO:0036342 post-anal tail morphogenesis IEA
 biological_processGO:0036517 chemoattraction of serotonergic neuron axon IEA
 biological_processGO:0036518 chemorepulsion of dopaminergic neuron axon IEA
 biological_processGO:0038031 non-canonical Wnt signaling pathway via JNK cascade IEA
 biological_processGO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042472 inner ear morphogenesis IEA
 biological_processGO:0042733 embryonic digit morphogenesis IEA
 biological_processGO:0043032 positive regulation of macrophage activation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045080 positive regulation of chemokine biosynthetic process IEA
 biological_processGO:0045165 cell fate commitment IBA
 biological_processGO:0045198 establishment of epithelial cell apical/basal polarity IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0045662 negative regulation of myoblast differentiation IDA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045778 positive regulation of ossification IEA
 biological_processGO:0045807 positive regulation of endocytosis IEA
 biological_processGO:0045836 positive regulation of meiotic nuclear division IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0046546 development of primary male sexual characteristics IEA
 biological_processGO:0048022 negative regulation of melanin biosynthetic process IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0048341 paraxial mesoderm formation IEA
 biological_processGO:0048546 digestive tract morphogenesis IEA
 biological_processGO:0048570 notochord morphogenesis IEA
 biological_processGO:0048706 embryonic skeletal system development IEA
 biological_processGO:0048806 genitalia development IEA
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0048843 negative regulation of axon extension involved in axon guidance IEA
 biological_processGO:0048850 hypophysis morphogenesis IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IEA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0050919 negative chemotaxis IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051885 positive regulation of timing of anagen IEA
 biological_processGO:0051964 negative regulation of synapse assembly IEA
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0060026 convergent extension IEA
 biological_processGO:0060028 convergent extension involved in axis elongation IEA
 biological_processGO:0060029 convergent extension involved in organogenesis IEA
 biological_processGO:0060065 uterus development IEA
 biological_processGO:0060067 cervix development IEA
 biological_processGO:0060068 vagina development IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway IEA
 biological_processGO:0060157 urinary bladder development IEA
 biological_processGO:0060324 face development IEA
 biological_processGO:0060340 positive regulation of type I interferon-mediated signaling pathway IEA
 biological_processGO:0060599 lateral sprouting involved in mammary gland duct morphogenesis IEA
 biological_processGO:0060606 tube closure IEA
 biological_processGO:0060638 mesenchymal-epithelial cell signaling IEA
 biological_processGO:0060686 negative regulation of prostatic bud formation IEA
 biological_processGO:0060744 mammary gland branching involved in thelarche IEA
 biological_processGO:0060750 epithelial cell proliferation involved in mammary gland duct elongation IEA
 biological_processGO:0060760 positive regulation of response to cytokine stimulus IEA
 biological_processGO:0060762 regulation of branching involved in mammary gland duct morphogenesis IEA
 biological_processGO:0060775 planar cell polarity pathway involved in gastrula mediolateral intercalation IEA
 biological_processGO:0060809 mesodermal to mesenchymal transition involved in gastrulation IEA
 biological_processGO:0060907 positive regulation of macrophage cytokine production IEA
 biological_processGO:0061036 positive regulation of cartilage development IEA
 biological_processGO:0061053 somite development IEA
 biological_processGO:0061347 planar cell polarity pathway involved in outflow tract morphogenesis IEA
 biological_processGO:0061348 planar cell polarity pathway involved in ventricular septum morphogenesis IEA
 biological_processGO:0061349 planar cell polarity pathway involved in cardiac right atrium morphogenesis IEA
 biological_processGO:0061350 planar cell polarity pathway involved in cardiac muscle tissue morphogenesis IEA
 biological_processGO:0061354 planar cell polarity pathway involved in pericardium morphogenesis IEA
 biological_processGO:0070245 positive regulation of thymocyte apoptotic process IEA
 biological_processGO:0071219 cellular response to molecule of bacterial origin IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071277 cellular response to calcium ion IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0071425 hematopoietic stem cell proliferation IEA
 biological_processGO:0071542 dopaminergic neuron differentiation IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0072201 negative regulation of mesenchymal cell proliferation IEA
 biological_processGO:0090009 primitive streak formation IEA
 biological_processGO:0090037 positive regulation of protein kinase C signaling IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090103 cochlea morphogenesis IEA
 biological_processGO:0090179 planar cell polarity pathway involved in neural tube closure IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090630 activation of GTPase activity IEA
 biological_processGO:0097325 melanocyte proliferation IEA
 biological_processGO:0150012 positive regulation of neuron projection arborization IEA
 biological_processGO:1900020 positive regulation of protein kinase C activity IEA
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1903827 regulation of cellular protein localization IEA
 biological_processGO:1904469 positive regulation of tumor necrosis factor secretion IEA
 biological_processGO:1904934 negative regulation of cell proliferation in midbrain IEA
 biological_processGO:1904938 planar cell polarity pathway involved in axon guidance IEA
 biological_processGO:1904948 midbrain dopaminergic neuron differentiation IEA
 biological_processGO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation IEA
 biological_processGO:2000049 positive regulation of cell-cell adhesion mediated by cadherin IEA
 biological_processGO:2000052 positive regulation of non-canonical Wnt signaling pathway IEA
 biological_processGO:2000484 positive regulation of interleukin-8 secretion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0009986 cell surface IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005109 frizzled binding IEA
 molecular_functionGO:0005115 receptor tyrosine kinase-like orphan receptor binding IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:1902379 chemoattractant activity involved in axon guidance IEA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking
Ca2+ pathway
Asymmetric localization of PCP proteins
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000005139 CLTC / clathrin heavy chain / Q00610*  / complex
 ENSGALG00000008432 AP2M1 / Q5ZMP6 / AP-2 complex subunit mu / P84091* / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / complex
 ENSGALG00000034101 FZD5 / frizzled class receptor 5 / Q13467* / Q9EQD0* / Frizzled-5 *  / complex / reaction
 ENSGALG00000015208 ROR2 / receptor tyrosine kinase like orphan receptor 2 / Q01974* / Q9Z138*  / complex / reaction
 ENSGALG00000017242 FZD4 / Q9IA05 / Frizzled-4 / Q61088* / Q9ULV1* / frizzled class receptor 4*  / complex / reaction
 ENSGALG00000042125 AP2B1 / adaptor related protein complex 2 beta 1 subunit / P63010* / Q9DBG3* / AP-2 complex subunit beta *  / complex






 

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