ENSMUSG00000021994


Mus musculus

Features
Gene ID: ENSMUSG00000021994
  
Biological name :Wnt5a
  
Synonyms : P22725 / wingless-type MMTV integration site family, member 5A / Wnt5a
  
Possible biological names infered from orthology : P41221 / Wnt family member 5A
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: A3
Gene start: 28504750
Gene end: 28527448
  
Corresponding Affymetrix probe sets: 10413482 (MoGene1.0st)   1436791_at (Mouse Genome 430 2.0 Array)   1437673_at (Mouse Genome 430 2.0 Array)   1448818_at (Mouse Genome 430 2.0 Array)   1456976_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000064878
Ensembl peptide - ENSMUSP00000107891
NCBI entrez gene - 22418     See in Manteia.
MGI - MGI:98958
RefSeq - XM_006518926
RefSeq - NM_001256224
RefSeq - NM_009524
RefSeq - XM_006518923
RefSeq - XM_006518924
RefSeq - XM_006518925
RefSeq Peptide - NP_033550
RefSeq Peptide - NP_001243153
swissprot - P22725
Ensembl - ENSMUSG00000021994
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnt5aENSDARG00000104973Danio rerio
 WNT5AENSGALG00000034168Gallus gallus
 WNT5AENSG00000114251Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wnt5b / P22726 / wingless-type MMTV integration site family, member 5B / Q9H1J7* / Wnt family member 5B*ENSMUSG0000003017076
Wnt2b / O70283 / wingless-type MMTV integration site family, member 2B / Q93097* / Wnt family member 2B*ENSMUSG0000002784046
Wnt2 / P21552 / wingless-type MMTV integration site family, member 2 / P09544* / Wnt family member 2*ENSMUSG0000001079745
Wnt4 / P22724 / wingless-type MMTV integration site family, member 4 / P56705* / Wnt family member 4*ENSMUSG0000003685644
Wnt7b / P28047 / wingless-type MMTV integration site family, member 7B / P56706* / Wnt family member 7B*ENSMUSG0000002238242
Wnt3a / P27467 / wingless-type MMTV integration site family, member 3A / P56704* / Wnt family member 3A*ENSMUSG0000000990041
Wnt3 / P17553 / wingless-type MMTV integration site family, member 3 / P56703* / Wnt family member 3*ENSMUSG0000000012541
Wnt7a / P24383 / wingless-type MMTV integration site family, member 7A / O00755* / Wnt family member 7A*ENSMUSG0000003009341
Wnt16 / Q9QYS1 / wingless-type MMTV integration site family, member 16 / Q9UBV4* / Wnt family member 16*ENSMUSG0000002967136
Wnt6 / P22727 / wingless-type MMTV integration site family, member 6 / Q9Y6F9* / Wnt family member 6*ENSMUSG0000003322736
Wnt11 / P48615 / wingless-type MMTV integration site family, member 11 / O96014* / Wnt family member 11*ENSMUSG0000001595736
Wnt1 / P04426 / wingless-type MMTV integration site family, member 1 / P04628* / Wnt family member 1*ENSMUSG0000002299735


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR018161  Wnt protein, conserved site
 IPR026538  Wnt-5a protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity ISO
 biological_processGO:0001667 ameboidal-type cell migration IMP
 biological_processGO:0001736 establishment of planar polarity IMP
 biological_processGO:0001756 somitogenesis IGI
 biological_processGO:0001819 positive regulation of cytokine production IDA
 biological_processGO:0001837 epithelial to mesenchymal transition IEA
 biological_processGO:0001843 neural tube closure IGI
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation ISO
 biological_processGO:0001947 heart looping IGI
 biological_processGO:0002009 morphogenesis of an epithelium IMP
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IMP
 biological_processGO:0002741 positive regulation of cytokine secretion involved in immune response ISO
 biological_processGO:0003323 type B pancreatic cell development IMP
 biological_processGO:0003344 pericardium morphogenesis IGI
 biological_processGO:0003401 axis elongation IMP
 biological_processGO:0003402 planar cell polarity pathway involved in axis elongation IMP
 biological_processGO:0006468 protein phosphorylation IGI
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway IDA
 biological_processGO:0007254 JNK cascade IDA
 biological_processGO:0007257 activation of JUN kinase activity ISO
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007409 axonogenesis IDA
 biological_processGO:0007411 axon guidance IDA
 biological_processGO:0007413 axonal fasciculation TAS
 biological_processGO:0007442 hindgut morphogenesis IMP
 biological_processGO:0007494 midgut development IMP
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0008595 anterior/posterior axis specification, embryo IDA
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration ISO
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IGI
 biological_processGO:0010820 positive regulation of T cell chemotaxis ISO
 biological_processGO:0010976 positive regulation of neuron projection development IDA
 biological_processGO:0016055 Wnt signaling pathway ISO
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0021891 olfactory bulb interneuron development IMP
 biological_processGO:0021915 neural tube development IGI
 biological_processGO:0022008 neurogenesis IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030216 keratinocyte differentiation IEA
 biological_processGO:0030324 lung development IMP
 biological_processGO:0030326 embryonic limb morphogenesis IMP
 biological_processGO:0030514 negative regulation of BMP signaling pathway IMP
 biological_processGO:0030825 obsolete positive regulation of cGMP metabolic process ISO
 biological_processGO:0030901 midbrain development IGI
 biological_processGO:0032092 positive regulation of protein binding IDA
 biological_processGO:0032148 activation of protein kinase B activity ISO
 biological_processGO:0032729 positive regulation of interferon-gamma production IMP
 biological_processGO:0032755 positive regulation of interleukin-6 production IDA
 biological_processGO:0032880 regulation of protein localization IDA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IGI
 biological_processGO:0034613 cellular protein localization ISO
 biological_processGO:0035108 limb morphogenesis IMP
 biological_processGO:0035567 non-canonical Wnt signaling pathway TAS
 biological_processGO:0036342 post-anal tail morphogenesis IMP
 biological_processGO:0036517 chemoattraction of serotonergic neuron axon IDA
 biological_processGO:0036518 chemorepulsion of dopaminergic neuron axon IDA
 biological_processGO:0038031 non-canonical Wnt signaling pathway via JNK cascade IMP
 biological_processGO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway IMP
 biological_processGO:0042060 wound healing ISO
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0042733 embryonic digit morphogenesis IMP
 biological_processGO:0043032 positive regulation of macrophage activation ISO
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0043507 positive regulation of JUN kinase activity IMP
 biological_processGO:0043547 positive regulation of GTPase activity IDA
 biological_processGO:0045080 positive regulation of chemokine biosynthetic process ISO
 biological_processGO:0045165 cell fate commitment IBA
 biological_processGO:0045198 establishment of epithelial cell apical/basal polarity IGI
 biological_processGO:0045599 negative regulation of fat cell differentiation ISO
 biological_processGO:0045732 positive regulation of protein catabolic process ISO
 biological_processGO:0045766 positive regulation of angiogenesis ISO
 biological_processGO:0045778 positive regulation of ossification ISO
 biological_processGO:0045807 positive regulation of endocytosis IDA
 biological_processGO:0045836 positive regulation of meiotic nuclear division IGI
 biological_processGO:0045860 positive regulation of protein kinase activity IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0046330 positive regulation of JNK cascade IMP
 biological_processGO:0046546 development of primary male sexual characteristics IMP
 biological_processGO:0048022 negative regulation of melanin biosynthetic process IDA
 biological_processGO:0048146 positive regulation of fibroblast proliferation ISO
 biological_processGO:0048341 paraxial mesoderm formation IGI
 biological_processGO:0048546 digestive tract morphogenesis IMP
 biological_processGO:0048570 notochord morphogenesis IGI
 biological_processGO:0048706 embryonic skeletal system development ISO
 biological_processGO:0048806 genitalia development ISO
 biological_processGO:0048812 neuron projection morphogenesis IDA
 biological_processGO:0048843 negative regulation of axon extension involved in axon guidance IGI
 biological_processGO:0048850 hypophysis morphogenesis IMP
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IMP
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IMP
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IMP
 biological_processGO:0050729 positive regulation of inflammatory response ISO
 biological_processGO:0050919 negative chemotaxis IGI
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0051885 positive regulation of timing of anagen IDA
 biological_processGO:0051964 negative regulation of synapse assembly IDA
 biological_processGO:0060021 roof of mouth development ISO
 biological_processGO:0060026 convergent extension IMP
 biological_processGO:0060028 convergent extension involved in axis elongation IMP
 biological_processGO:0060029 convergent extension involved in organogenesis IGI
 biological_processGO:0060065 uterus development IMP
 biological_processGO:0060067 cervix development IMP
 biological_processGO:0060068 vagina development IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IMP
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway ISO
 biological_processGO:0060157 urinary bladder development IMP
 biological_processGO:0060324 face development ISO
 biological_processGO:0060340 positive regulation of type I interferon-mediated signaling pathway ISO
 biological_processGO:0060599 lateral sprouting involved in mammary gland duct morphogenesis IDA
 biological_processGO:0060606 tube closure IMP
 biological_processGO:0060638 mesenchymal-epithelial cell signaling IMP
 biological_processGO:0060686 negative regulation of prostatic bud formation IMP
 biological_processGO:0060744 mammary gland branching involved in thelarche IDA
 biological_processGO:0060750 epithelial cell proliferation involved in mammary gland duct elongation IDA
 biological_processGO:0060760 positive regulation of response to cytokine stimulus ISO
 biological_processGO:0060762 regulation of branching involved in mammary gland duct morphogenesis IGI
 biological_processGO:0060775 planar cell polarity pathway involved in gastrula mediolateral intercalation IGI
 biological_processGO:0060809 mesodermal to mesenchymal transition involved in gastrulation IGI
 biological_processGO:0060907 positive regulation of macrophage cytokine production ISO
 biological_processGO:0061036 positive regulation of cartilage development IMP
 biological_processGO:0061053 somite development IGI
 biological_processGO:0061347 planar cell polarity pathway involved in outflow tract morphogenesis IMP
 biological_processGO:0061348 planar cell polarity pathway involved in ventricular septum morphogenesis IMP
 biological_processGO:0061349 planar cell polarity pathway involved in cardiac right atrium morphogenesis IMP
 biological_processGO:0061350 planar cell polarity pathway involved in cardiac muscle tissue morphogenesis IMP
 biological_processGO:0061354 planar cell polarity pathway involved in pericardium morphogenesis IMP
 biological_processGO:0070245 positive regulation of thymocyte apoptotic process IMP
 biological_processGO:0071219 cellular response to molecule of bacterial origin IDA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071277 cellular response to calcium ion IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0071425 hematopoietic stem cell proliferation ISO
 biological_processGO:0071542 dopaminergic neuron differentiation IDA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0072201 negative regulation of mesenchymal cell proliferation ISO
 biological_processGO:0090009 primitive streak formation IGI
 biological_processGO:0090037 positive regulation of protein kinase C signaling ISO
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IDA
 biological_processGO:0090103 cochlea morphogenesis IMP
 biological_processGO:0090179 planar cell polarity pathway involved in neural tube closure IMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IDA
 biological_processGO:0090630 activation of GTPase activity IDA
 biological_processGO:0097325 melanocyte proliferation IDA
 biological_processGO:0150012 positive regulation of neuron projection arborization IGI
 biological_processGO:1900020 positive regulation of protein kinase C activity ISO
 biological_processGO:1901216 positive regulation of neuron death IDA
 biological_processGO:1903827 regulation of cellular protein localization IDA
 biological_processGO:1904469 positive regulation of tumor necrosis factor secretion IMP
 biological_processGO:1904934 negative regulation of cell proliferation in midbrain IMP
 biological_processGO:1904938 planar cell polarity pathway involved in axon guidance IMP
 biological_processGO:1904948 midbrain dopaminergic neuron differentiation IMP
 biological_processGO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation IDA
 biological_processGO:2000049 positive regulation of cell-cell adhesion mediated by cadherin IDA
 biological_processGO:2000052 positive regulation of non-canonical Wnt signaling pathway IDA
 biological_processGO:2000484 positive regulation of interleukin-8 secretion IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0009986 cell surface IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005109 frizzled binding IPI
 molecular_functionGO:0005115 receptor tyrosine kinase-like orphan receptor binding ISO
 molecular_functionGO:0005125 cytokine activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISO
 molecular_functionGO:1902379 chemoattractant activity involved in axon guidance IDA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking
Ca2+ pathway
PCP/CE pathway
Asymmetric localization of PCP proteins
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000018 small ears "outer ears of a smaller than normal size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Plxnd1b2b3150Clo/Plxnd1b2b3150Clo
Genetic Background: C57BL/6J-Plxnd1b2b3150Clo

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+,Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1Clo
Genetic Background: C57BL/6J-Wnt5ab2b3077.1Clo

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: H2afvTg(Wnt1-cre)11Rth/0,Wnt5atm1Amc/Wnt5atm1.1Krvl
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * CBA/J

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1Clo
Genetic Background: C57BL/6J-Wnt5ab2b3077.1Clo

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1Clo
Genetic Background: C57BL/6J-Wnt5ab2b3077.1Clo

 MP:0000492 abnormal rectum morphology "structural aberration in the terminal portion of the intestinal tube adjacent to the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000538 abnormal urinary bladder morphology "malformation of the inflatable musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000561 adactyly "missing all digits; usually refered to as a congenital condition" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1Clo
Genetic Background: C57BL/6J-Wnt5ab2b3077.1Clo

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

Allelic Composition: Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1Clo
Genetic Background: C57BL/6J-Wnt5ab2b3077.1Clo

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
Show

Allelic Composition: Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt5atm1Amc/Wnt5a+
Genetic Background: involves: 129 * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tg(ACTFLPe)9205Dym/0,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Wnt4tm1Amc/Wnt4+,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5a+,Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tg(ACTFLPe)9205Dym/0,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5a+,Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0001011 abnormal superior cervical ganglion morphology "malformation or absence of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cers6tm1Arte/Cers6tm1Arte,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Wnt5atm1.1Tpy/Wnt5atm1.1Tpy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
Show

Allelic Composition: Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1Clo
Genetic Background: C57BL/6J-Wnt5ab2b3077.1Clo

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Ror1tm1.1Meg/Ror1tm1.1Meg,Ror2tm1.1Meg/Ror2tm1.1Meg
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Wnt5atm1.1Tpy/Wnt5atm1.1Tpy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001729 impaired implantation "impaired ability of the blastocyst to attach to the endometrium of the uterus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Wnt5atm1.1Tpy/Wnt5atm1.1Tpy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1Clo
Genetic Background: C57BL/6J-Wnt5ab2b3077.1Clo

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Wnt5atm1.1Tpy/Wnt5atm1.1Tpy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Wnt5atm1.1Tpy/Wnt5atm1.1Tpy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tg(ACTFLPe)9205Dym/0,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Wnt4tm1Amc/Wnt4+,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5a+,Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1Clo
Genetic Background: C57BL/6J-Wnt5ab2b3077.1Clo

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1Clo
Genetic Background: C57BL/6J-Wnt5ab2b3077.1Clo

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plxnd1b2b3150Clo/Plxnd1b2b3150Clo
Genetic Background: C57BL/6J-Plxnd1b2b3150Clo

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: En1tm2(cre)Wrst/En1+,Tor1atm2Wtd/Tor1atm3.1Wtd
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * SJL

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+,Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+,Wnt5atm1Amc/Wnt5a+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0002230 abnormal primitive streak formation "anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002276 abnormal lung interstitium morphology "any structural anomaly of the lung tissue, but not including the conducting airways (bronchi, bronchioles, alveoli) " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002632 vestigial tail "a trace or rudimentary tail structure; the degenerated remains of any tail structure" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1Clo
Genetic Background: C57BL/6J-Wnt5ab2b3077.1Clo

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1Clo
Genetic Background: C57BL/6J-Wnt5ab2b3077.1Clo

 MP:0002982 abnormal germ cell migration "defects in the orderly movement of a germ cell, a cell specialized to produce haploid gametes, from one site to another during development" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003119 abnormal digestive system development "dysmorphology of the organ system that converts ingested food to nutrients and energy" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0003130 anal atresia "absence of a connection between the anal pit and the rectum" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91491]
Show

Allelic Composition: Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: H2afvTg(Wnt1-cre)11Rth/0,Wnt5atm1Amc/Wnt5atm1.1Krvl
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * CBA/J

 MP:0003380 abnormal intestine regeneration "deviation from the normal ability of the intestine to regenerate healthy tissue following injury" [J:93428, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nlgn3tm1Rhn/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wnt5atm1.1Tpy/Wnt5atm1.1Tpy,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: H2afvTg(Wnt1-cre)11Rth/0,Wnt5atm1Amc/Wnt5atm1.1Krvl
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * CBA/J

 MP:0003920 abnormal right ventricle morphology "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+,Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt5atm1Amc/Wnt5a+
Genetic Background: involves: 129 * C57BL/6

 MP:0004056 abnormal myocardial compact layer morphology "malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+,Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0004256 abnormal maternal decidual layer morphology "anomaly in the structure of the maternal uterine-derived portion of the placenta" [PMID:11433360]
Show

Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Wnt5atm1.1Tpy/Wnt5atm1.1Tpy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0004355 short radius "reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0004550 short trachea "reduced length of the tube descending from the larynx and branching into the right and left main bronchi" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0004551 decreased tracheal cartilage ring number "less than the 16-20 incomplete rings of hyaline cartilage forming the skeleton of the trachea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0004609 vertebral fusion "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0004610 small vertebrae "reduced size of the bony segments of the spinal column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0004653 absent caudal vertebrae "absence of all of the bony segments of the coccyx or tail; there are usually 27-30 present in rodents and only 3-5 fused vertebrae in human" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0004704 short vertebral column "decreased rostral-caudal length of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0004733 abnormal thoracic cavity "any structural anomaly of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1Clo
Genetic Background: C57BL/6J-Wnt5ab2b3077.1Clo

 MP:0005023 abnormal wound healing "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nlgn3tm1Rhn/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wnt5atm1.1Tpy/Wnt5atm1.1Tpy,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

 MP:0005034 abnormal anus morphology "structural anomaly of the lower opening of the digestive tract" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005170 cleft lip "defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1Clo
Genetic Background: C57BL/6J-Wnt5ab2b3077.1Clo

 MP:0006301 abnormal mesenchyme morphology "abnormality in the loosely packed, unspecialized cells that derive mostly from the mesoderm and contribute to connective tissue, bone, cartilage and circulatory and lymphatic systems." [J:120305, mnk:Michelle Knowlton_MGI Curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0008392 decreased primordial germ cell number "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Cers6tm1Arte/Cers6tm1Arte,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0008999 absent anus "absence of the lower opening of the digestive tract" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009204 absent external male genitalia "absence of the external masculine genital organs, including the penis and scrotum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0009211 absent external female genitalia "absence of the external feminine genital organs, collectively known as the vulva" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0009284 abnormal sympathetic neuron innervation "defective or incomplete supply of nerve fibers to sympathetic termini" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H2afvTg(Wnt1-cre)11Rth/0,Wnt5atm1Amc/Wnt5atm1.1Krvl
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * CBA/J

Allelic Composition: Tg(Th-cre)#Gsat/0,Wnt5atm1.1Krvl/Wnt5atm1.1Krvl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0009352 impaired spacing of implantation sites "in organisms which give birth to multiple offspring in one litter, blastocysts fail to implant at intervals conducive to the formation of a normal enveloping membrane or decidua for each conceptus from the epithelial tissue of the endometrium lining of the uterus" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Wnt5atm1.1Tpy/Wnt5atm1.1Tpy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009353 twin decidual capsule "two embryos share one decidual membrane" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Wnt5atm1.1Tpy/Wnt5atm1.1Tpy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009509 absent rectum "absence or loss of the terminal portion of the intestinal tube adjacent to the anus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009663 abnormal uterine-embryonic axis "any anomaly in the process whereby the implantation chamber orients in the uterus in response to decidual growth to insure correct alignment of the embryo to the uterus" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:10882512 "Carson DD, et al, Embryo implantation Dev Biol. 2000 Jul 15;223(2):217-37."]
Show

Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Wnt5atm1.1Tpy/Wnt5atm1.1Tpy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009666 abnormal embryo attachment "any anomaly in the process whereby the blastocyst anchors to the uterine luminal epithelium and cannot be dislodged by flushing" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:10882512 "Carson DD, et al, Embryo implantation Dev Biol. 2000 Jul 15;223(2):217-37."]
Show

Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Wnt5atm1.1Tpy/Wnt5atm1.1Tpy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009705 abnormal midgut morphology "any structural anomaly of the portion of the embryonic gut between the foregut and the hindgut, which originally is open to the yolk sac" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0009907 decreased tongue size "reduced size of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0010039 abnormal trophoblast giant cell proliferation "abnormality in the expansion rate of the trophoblast giant cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Wnt5atm1.1Tpy/Wnt5atm1.1Tpy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
Show

Allelic Composition: Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1Clo
Genetic Background: C57BL/6J-Wnt5ab2b3077.1Clo

 MP:0010446 heart left ventricle hypoplasia "underdevelopment or reduced size of the heart left ventricle, often due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1Clo
Genetic Background: C57BL/6J-Wnt5ab2b3077.1Clo

 MP:0010460 pulmonary artery hypoplasia "underdevelopment or reduced size of the artery that arises from the right ventricle and conveys unaerated blood to the lungs, usually due to reduced cell number" [MESH:A07.231.114.715]
Show

Allelic Composition: Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1Clo
Genetic Background: C57BL/6J-Wnt5ab2b3077.1Clo

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: H2afvTg(Wnt1-cre)11Rth/0,Wnt5atm1Amc/Wnt5atm1.1Krvl
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * CBA/J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tg(ACTFLPe)9205Dym/0,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt5atm1Amc/Wnt5a+
Genetic Background: involves: 129 * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+,Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0011521 decreased placental labyrinth size "reduction in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
Show

Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Wnt5atm1.1Tpy/Wnt5atm1.1Tpy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011610 abnormal primordial germ cell apoptosis "change in the timing or the number of primordial germ cells undergoing programmed cell death" [MGI:smb]
Show

Allelic Composition: Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0011772 genital tubercle hypoplasia "underdevelopment or reduced size of the embryonic anlage of the external genitalia, usually due to a reduced number of cells" [MGI:anna]
Show

Allelic Composition: Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0012182 abnormal presomitic mesoderm morphology "any structural anomaly of the unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form" [MGI:anna]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0013956 decreased colon length "reduced length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088]
Show

Allelic Composition: Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0030564 thick myocardium compact layer "increased thickness of the outer, dense layer of the myocardium" [MGI:anna, PMID:26526197]
Show

Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+,Wnt5atm1Amc/Wnt5a+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002957 Ap2a2 / P17427 / Mus musculus adaptor-related protein complex 2, alpha 2 subunit (Ap2a2), transcript variant 1, mRNA. / O94973* / adaptor related protein complex 2 alpha 2 subunit*  / reaction / complex
 ENSMUSG00000022841 Ap2m1 / P84091 / AP-2 complex subunit mu / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / reaction / complex
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / complex / reaction
 ENSMUSG00000035152 Ap2b1 / Q9DBG3 / AP-2 complex subunit beta / P63010* / adaptor related protein complex 2 beta 1 subunit*  / reaction / complex
 ENSMUSG00000020218 Wif1 / Q9WUA1 / Wnt inhibitory factor 1 / Q9Y5W5*  / reaction / complex
 ENSMUSG00000021464 Ror2 / Q9Z138 / receptor tyrosine kinase-like orphan receptor 2 / Q01974*  / reaction / complex
 ENSMUSG00000026556 Q91ZD4 / Vangl2 / VANGL planar cell polarity 2 / Q9ULK5* / VANGL planar cell polarity protein 2*  / complex / reaction
 ENSMUSG00000036904 Fzd8 / Q61091 / Frizzled-8 / Q9H461* / frizzled class receptor 8*  / reaction / complex
 ENSMUSG00000045005 Fzd5 / Q9EQD0 / Frizzled-5 / Q13467* / frizzled class receptor 5*  / complex / reaction
 ENSMUSG00000018909 Arrb1 / Q8BWG8 / Beta-arrestin-1 / P49407* / arrestin beta 1*  / complex / reaction
 ENSMUSG00000060279 Ap2a1 / P17426 / AP-2 complex subunit alpha-1 / O95782* / adaptor related protein complex 2 alpha 1 subunit*  / complex / reaction
 ENSMUSG00000060216 Arrb2 / Q91YI4 / Beta-arrestin-2 / P32121* / arrestin beta 2*  / reaction / complex
 ENSMUSG00000050288 Fzd2 / Q9JIP6 / Frizzled-2 / Q14332* / frizzled class receptor 2*  / complex / reaction
 ENSMUSG00000008036 Ap2s1 / P62743 / AP-2 complex subunit sigma / P53680* / adaptor related protein complex 2 sigma 1 subunit*  / complex / reaction
 ENSMUSG00000049791 Fzd4 / Q61088 / Frizzled-4 / Q9ULV1* / frizzled class receptor 4*  / complex / reaction
 ENSMUSG00000041075 Fzd7 / Q61090 / Frizzled-7 / O75084* / frizzled class receptor 7*  / reaction / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr