ENSMUSG00000010797


Mus musculus

Features
Gene ID: ENSMUSG00000010797
  
Biological name :Wnt2
  
Synonyms : P21552 / wingless-type MMTV integration site family, member 2 / Wnt2
  
Possible biological names infered from orthology : P09544 / Wnt family member 2
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: A2
Gene start: 17988940
Gene end: 18030585
  
Corresponding Affymetrix probe sets: 10543253 (MoGene1.0st)   1449425_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000010941
NCBI entrez gene - 22413     See in Manteia.
MGI - MGI:98954
RefSeq - NM_023653
RefSeq - XM_006505045
RefSeq Peptide - NP_076142
swissprot - P21552
Ensembl - ENSMUSG00000010797
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnt2ENSDARG00000041117Danio rerio
 WNT2ENSGALG00000030173Gallus gallus
 WNT2ENSG00000105989Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wnt2b / O70283 / wingless-type MMTV integration site family, member 2B / Q93097* / Wnt family member 2B*ENSMUSG0000002784068
Wnt5b / P22726 / wingless-type MMTV integration site family, member 5B / Q9H1J7* / Wnt family member 5B*ENSMUSG0000003017047
Wnt5a / P22725 / wingless-type MMTV integration site family, member 5A / P41221* / Wnt family member 5A*ENSMUSG0000002199447
Wnt4 / P22724 / wingless-type MMTV integration site family, member 4 / P56705* / Wnt family member 4*ENSMUSG0000003685644
Wnt7b / P28047 / wingless-type MMTV integration site family, member 7B / P56706* / Wnt family member 7B*ENSMUSG0000002238244
Wnt7a / P24383 / wingless-type MMTV integration site family, member 7A / O00755* / Wnt family member 7A*ENSMUSG0000003009344
Wnt3 / P17553 / wingless-type MMTV integration site family, member 3 / P56703* / Wnt family member 3*ENSMUSG0000000012543
Wnt3a / P27467 / wingless-type MMTV integration site family, member 3A / P56704* / Wnt family member 3A*ENSMUSG0000000990041
Wnt1 / P04426 / wingless-type MMTV integration site family, member 1 / P04628* / Wnt family member 1*ENSMUSG0000002299740
Wnt16 / Q9QYS1 / wingless-type MMTV integration site family, member 16 / Q9UBV4* / Wnt family member 16*ENSMUSG0000002967140
Wnt6 / P22727 / wingless-type MMTV integration site family, member 6 / Q9Y6F9* / Wnt family member 6*ENSMUSG0000003322738
Wnt11 / P48615 / wingless-type MMTV integration site family, member 11 / O96014* / Wnt family member 11*ENSMUSG0000001595735


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR009140  Wnt-2 protein
 IPR018161  Wnt protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IMP
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016055 Wnt signaling pathway ISO
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0033278 cell proliferation in midbrain IEA
 biological_processGO:0045165 cell fate commitment IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0055009 atrial cardiac muscle tissue morphogenesis IMP
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060317 cardiac epithelial to mesenchymal transition IMP
 biological_processGO:0060492 lung induction IGI
 biological_processGO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis IMP
 biological_processGO:0060716 labyrinthine layer blood vessel development IMP
 biological_processGO:0061180 mammary gland epithelium development IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1904948 midbrain dopaminergic neuron differentiation IEA
 biological_processGO:1904954 canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005109 frizzled binding IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0048018 receptor ligand activity IEA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
Show

Allelic Composition: Hunktm1Lach/Hunk+,Tg(MMTV-Myc)#Led/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

 MP:0001181 absent lungs "missing organs of respiration" [J:51966, J:50768]
Show

Allelic Composition: Hunktm1Lach/Hunk+,Tg(MMTV-Myc)#Led/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Hunktm1Lach/Hunk+,Tg(MMTV-Myc)#Led/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hunktm1Lach/Hunk+,Tg(MMTV-Myc)#Led/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hunktm1Lach/Hunk+,Tg(MMTV-Myc)#Led/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

 MP:0004197 abnormal fetal growth/weight/body size "limited or accelerated growth or development apparent during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010885 absent trachea "absence of the tube descending from the larynx and branching into the right and left main bronchi" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hunktm1Lach/Hunk+,Tg(MMTV-Myc)#Led/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Hunktm1Lach/Hunk+,Tg(MMTV-Myc)#Led/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011142 abnormal lung-associated mesenchyme development "abnormality in the formation of the lung tissue comprised of multiple cell types (including connective tissue, endothelial cells, lymphatics, smooth muscle cells surrounding airways and blood vessels, myofibroblasts involved in septum formation, and cartilage-forming cells in the trachea), with most cells thought to be derived from the splanchnic mesenchyme, and other cells (endothelial, smooth muscle) believed to invade the lung as it expands; lung mesenchyme is a critical determinant of the shape and size of the developing lung, the extent and patterning of epithelial branching, and the formation of the pulmonary vasculature and interstitial mesenchymal components of the adult lung" [MGI:anna, PMID:18533146, PMID:20048339]
Show

Allelic Composition: Hunktm1Lach/Hunk+,Tg(MMTV-Myc)#Led/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

 MP:0011148 decreased mesenchymal cell proliferation involved in lung development "reduction in the expansion rate of a lung mesenchymal cell population by cell division" [MGI:anna]
Show

Allelic Composition: Hunktm1Lach/Hunk+,Tg(MMTV-Myc)#Led/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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