ENSMUSG00000030170


Mus musculus

Features
Gene ID: ENSMUSG00000030170
  
Biological name :Wnt5b
  
Synonyms : P22726 / wingless-type MMTV integration site family, member 5B / Wnt5b
  
Possible biological names infered from orthology : Q9H1J7 / Wnt family member 5B
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F1
Gene start: 119432531
Gene end: 119544347
  
Corresponding Affymetrix probe sets: 10547396 (MoGene1.0st)   1422602_a_at (Mouse Genome 430 2.0 Array)   1439373_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000137065
Ensembl peptide - ENSMUSP00000112448
Ensembl peptide - ENSMUSP00000112819
Ensembl peptide - ENSMUSP00000113188
NCBI entrez gene - 22419     See in Manteia.
MGI - MGI:98959
RefSeq - XM_017321520
RefSeq - NM_001271757
RefSeq - NM_001271758
RefSeq - NM_009525
RefSeq - XM_006505924
RefSeq Peptide - NP_001258686
RefSeq Peptide - NP_001258687
RefSeq Peptide - NP_033551
swissprot - D3YTW9
swissprot - P22726
swissprot - A0A0R4J1M1
Ensembl - ENSMUSG00000030170
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnt5bENSDARG00000102464Danio rerio
 WNT5BENSGALG00000012998Gallus gallus
 WNT5BENSG00000111186Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wnt5a / P22725 / wingless-type MMTV integration site family, member 5A / P41221* / Wnt family member 5A*ENSMUSG0000002199481
Wnt2b / O70283 / wingless-type MMTV integration site family, member 2B / Q93097* / Wnt family member 2B*ENSMUSG0000002784049
Wnt2 / P21552 / wingless-type MMTV integration site family, member 2 / P09544* / Wnt family member 2*ENSMUSG0000001079747
Wnt4 / P22724 / wingless-type MMTV integration site family, member 4 / P56705* / Wnt family member 4*ENSMUSG0000003685645
Wnt7b / P28047 / wingless-type MMTV integration site family, member 7B / P56706* / Wnt family member 7B*ENSMUSG0000002238245
Wnt3a / P27467 / wingless-type MMTV integration site family, member 3A / P56704* / Wnt family member 3A*ENSMUSG0000000990044
Wnt3 / P17553 / wingless-type MMTV integration site family, member 3 / P56703* / Wnt family member 3*ENSMUSG0000000012544
Wnt7a / P24383 / wingless-type MMTV integration site family, member 7A / O00755* / Wnt family member 7A*ENSMUSG0000003009343
Wnt6 / P22727 / wingless-type MMTV integration site family, member 6 / Q9Y6F9* / Wnt family member 6*ENSMUSG0000003322740
Wnt16 / Q9QYS1 / wingless-type MMTV integration site family, member 16 / Q9UBV4* / Wnt family member 16*ENSMUSG0000002967140
Wnt11 / P48615 / wingless-type MMTV integration site family, member 11 / O96014* / Wnt family member 11*ENSMUSG0000001595738
Wnt1 / P04426 / wingless-type MMTV integration site family, member 1 / P04628* / Wnt family member 1*ENSMUSG0000002299737


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR018161  Wnt protein, conserved site
 IPR026537  Wnt-5b protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002062 chondrocyte differentiation IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0016055 Wnt signaling pathway ISO
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0045165 cell fate commitment IBA
 biological_processGO:0045600 positive regulation of fat cell differentiation IGI
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IGI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0009986 cell surface IDA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005109 frizzled binding IBA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking
PCP/CE pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Wnt4tm1Amc/Wnt4+,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5a+,Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5a+,Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Wnt4tm1Amc/Wnt4+,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5a+,Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nsd3tm1b(EUCOMM)Hmgu/Nsd3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nsd3tm1b(EUCOMM)Hmgu/H

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Nsd3tm1b(EUCOMM)Hmgu/Nsd3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nsd3tm1b(EUCOMM)Hmgu/H

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tg(ACTFLPe)9205Dym/0,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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