ENSMUSG00000030093


Mus musculus

Features
Gene ID: ENSMUSG00000030093
  
Biological name :Wnt7a
  
Synonyms : P24383 / wingless-type MMTV integration site family, member 7A / Wnt7a
  
Possible biological names infered from orthology : O00755 / Wnt family member 7A
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D1
Gene start: 91363981
Gene end: 91411363
  
Corresponding Affymetrix probe sets: 10546339 (MoGene1.0st)   1423367_at (Mouse Genome 430 2.0 Array)   1447647_at (Mouse Genome 430 2.0 Array)   1458334_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032180
NCBI entrez gene - 22421     See in Manteia.
MGI - MGI:98961
RefSeq - NM_009527
RefSeq Peptide - NP_033553
swissprot - P24383
Ensembl - ENSMUSG00000030093
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnt7aaENSDARG00000044827Danio rerio
 wnt7abENSDARG00000002483Danio rerio
 WNT7AENSGALG00000005123Gallus gallus
 WNT7AENSG00000154764Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wnt7b / P28047 / wingless-type MMTV integration site family, member 7B / P56706* / Wnt family member 7B*ENSMUSG0000002238278
Wnt2b / O70283 / wingless-type MMTV integration site family, member 2B / Q93097* / Wnt family member 2B*ENSMUSG0000002784047
Wnt2 / P21552 / wingless-type MMTV integration site family, member 2 / P09544* / Wnt family member 2*ENSMUSG0000001079745
Wnt5a / P22725 / wingless-type MMTV integration site family, member 5A / P41221* / Wnt family member 5A*ENSMUSG0000002199445
Wnt4 / P22724 / wingless-type MMTV integration site family, member 4 / P56705* / Wnt family member 4*ENSMUSG0000003685645
Wnt5b / P22726 / wingless-type MMTV integration site family, member 5B / Q9H1J7* / Wnt family member 5B*ENSMUSG0000003017044
Wnt3 / P17553 / wingless-type MMTV integration site family, member 3 / P56703* / Wnt family member 3*ENSMUSG0000000012543
Wnt3a / P27467 / wingless-type MMTV integration site family, member 3A / P56704* / Wnt family member 3A*ENSMUSG0000000990042
Wnt16 / Q9QYS1 / wingless-type MMTV integration site family, member 16 / Q9UBV4* / Wnt family member 16*ENSMUSG0000002967140
Wnt1 / P04426 / wingless-type MMTV integration site family, member 1 / P04628* / Wnt family member 1*ENSMUSG0000002299739
Wnt6 / P22727 / wingless-type MMTV integration site family, member 6 / Q9Y6F9* / Wnt family member 6*ENSMUSG0000003322739
Wnt11 / P48615 / wingless-type MMTV integration site family, member 11 / O96014* / Wnt family member 11*ENSMUSG0000001595736


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR013300  Wnt-7 protein
 IPR018161  Wnt protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000578 embryonic axis specification IEA
 biological_processGO:0001502 cartilage condensation IEA
 biological_processGO:0001525 angiogenesis IGI
 biological_processGO:0002062 chondrocyte differentiation IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007269 neurotransmitter secretion IGI
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IDA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0014719 skeletal muscle satellite cell activation IDA
 biological_processGO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IDA
 biological_processGO:0016055 Wnt signaling pathway IGI
 biological_processGO:0021707 cerebellar granule cell differentiation IDA
 biological_processGO:0021846 cell proliferation in forebrain IEA
 biological_processGO:0022009 central nervous system vasculogenesis IGI
 biological_processGO:0030010 establishment of cell polarity IDA
 biological_processGO:0030326 embryonic limb morphogenesis IGI
 biological_processGO:0031133 regulation of axon diameter IDA
 biological_processGO:0032270 positive regulation of cellular protein metabolic process IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0035019 somatic stem cell population maintenance IMP
 biological_processGO:0035115 embryonic forelimb morphogenesis IEA
 biological_processGO:0035116 embryonic hindlimb morphogenesis IEA
 biological_processGO:0035567 non-canonical Wnt signaling pathway IGI
 biological_processGO:0035659 Wnt signaling pathway involved in wound healing, spreading of epidermal cells IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0042733 embryonic digit morphogenesis IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043627 response to estrogen IMP
 biological_processGO:0045165 cell fate commitment IBA
 biological_processGO:0045167 asymmetric protein localization involved in cell fate determination IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0048103 somatic stem cell division IDA
 biological_processGO:0048864 stem cell development IEA
 biological_processGO:0050768 negative regulation of neurogenesis IEA
 biological_processGO:0050770 regulation of axonogenesis IDA
 biological_processGO:0050808 synapse organization IMP
 biological_processGO:0051216 cartilage development IDA
 biological_processGO:0051965 positive regulation of synapse assembly IEA
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0060054 positive regulation of epithelial cell proliferation involved in wound healing IEA
 biological_processGO:0060065 uterus development IMP
 biological_processGO:0060066 oviduct development IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060173 limb development IDA
 biological_processGO:0060997 dendritic spine morphogenesis IGI
 biological_processGO:0061038 uterus morphogenesis IMP
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1904891 positive regulation of excitatory synapse assembly IEA
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005109 frizzled binding IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0048018 receptor ligand activity IEA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000461 reduced number of presacral vertebrae "redecued number of the vertebrae anterior to the sacrum" [J:13069]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

Allelic Composition: En1tm1Alj/En1tm1Alj,Wnt7atm1Amc/Wnt7atm1Amc,Tg(Wnt1-En1)1Amc/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

Allelic Composition: Wnt7apx-J/Wnt7apx-J
Genetic Background: C57BL/6J-Wnt7apx-J/GrsrJ

Allelic Composition: Wnt7apx-2J/Wnt7apx-2J
Genetic Background: B6;C3Fe-Wnt7apx-2J/GrsrJ

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Wnt7am1Btlr/Wnt7am1Btlr
Genetic Background: C57BL/6J-Wnt7am1Btlr

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

Allelic Composition: Wnt7atm1Amc/Wnt7atm1Amc
Genetic Background: involves: 129S1/Sv

Allelic Composition: Wnt7apx-r/Wnt7apx-r
Genetic Background: HR

Allelic Composition: En1tm1Alj/En1tm1Alj,Wnt7atm1Amc/Wnt7atm1Amc,Tg(Wnt1-En1)1Amc/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

Allelic Composition: Wnt7apx-J/Wnt7apx-J
Genetic Background: C57BL/6J-Wnt7apx-J/GrsrJ

Allelic Composition: Wnt7apx-2J/Wnt7apx-2J
Genetic Background: B6;C3Fe-Wnt7apx-2J/GrsrJ

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: En1tm1Alj/En1tm1Alj,Wnt7atm1Amc/Wnt7atm1Amc,Tg(Wnt1-En1)1Amc/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

 MP:0000574 abnormal foot pad morphology "anomalous structure of the body of fat on the foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: En1tm1Alj/En1tm1Alj,Wnt7atm1Amc/Wnt7atm1Amc,Tg(Wnt1-En1)1Amc/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt7atm1Amc/Wnt7atm1Amc
Genetic Background: involves: 129S1/Sv

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Wnt7apx-2J/Wnt7apx-2J
Genetic Background: B6;C3Fe-Wnt7apx-2J/GrsrJ

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt7apx-2J/Wnt7apx-2J
Genetic Background: B6;C3Fe-Wnt7apx-2J/GrsrJ

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nbntm3Jpt/Nbntm3Jpt
Genetic Background: involves: 129/Sv

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Wnt7atm1Amc/Wnt7atm1Amc,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nbntm3Jpt/Nbntm3Jpt
Genetic Background: involves: 129/Sv

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Wnt7atm1Amc/Wnt7atm1Amc,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Wnt7am1Btlr/Wnt7am1Btlr
Genetic Background: C57BL/6J-Wnt7am1Btlr

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

Allelic Composition: Wnt7atm1Amc/Wnt7atm1Amc
Genetic Background: involves: 129S1/Sv

Allelic Composition: Wnt7apx-J/Wnt7apx-J
Genetic Background: C57BL/6J-Wnt7apx-J/GrsrJ

Allelic Composition: Wnt7apx-2J/Wnt7apx-2J
Genetic Background: B6;C3Fe-Wnt7apx-2J/GrsrJ

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

Allelic Composition: Wnt7atm1Amc/Wnt7atm1Amc
Genetic Background: involves: 129S1/Sv

Allelic Composition: Wnt7apx-r/Wnt7apx-r
Genetic Background: HR

Allelic Composition: Wnt7atm1.1Tesp/Wnt7atm1.1Tesp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Wnt7apx-J/Wnt7apx-J
Genetic Background: C57BL/6J-Wnt7apx-J/GrsrJ

Allelic Composition: Wnt7apx-2J/Wnt7apx-2J
Genetic Background: B6;C3Fe-Wnt7apx-2J/GrsrJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: En1tm1Alj/En1tm1Alj,Wnt7atm1Amc/Wnt7atm1Amc,Tg(Wnt1-En1)1Amc/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

Allelic Composition: Wnt7am1Btlr/Wnt7am1Btlr
Genetic Background: C57BL/6J-Wnt7am1Btlr

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: En1tm1Alj/En1tm1Alj,Wnt7atm1Amc/Wnt7atm1Amc,Tg(Wnt1-En1)1Amc/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

Allelic Composition: Wnt7am1Btlr/Wnt7am1Btlr
Genetic Background: C57BL/6J-Wnt7am1Btlr

Allelic Composition: Wnt7apx-2J/Wnt7apx-2J
Genetic Background: B6;C3Fe-Wnt7apx-2J/GrsrJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nrltm1.1(Thrb)Df/Nrltm1.1(Thrb)Df
Genetic Background: involves: C57BL/6

 MP:0002637 small uterus "reduced size of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt7atm1Amc/Wnt7atm1Amc
Genetic Background: involves: 129S1/Sv

 MP:0002674 abnormal sperm motility "anomalies in the mobility of the spermatozoa" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Wnt7apx-J/Wnt7apx-J
Genetic Background: C57BL/6J-Wnt7apx-J/GrsrJ

 MP:0002765 short fibula "reduced length of the lateral and smaller of bone of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:12736]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0003572 abnormal uterus development "abnormal morphogenesis of the female muscular organ of gestation" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Wnt7atm1Amc/Wnt7atm1Amc
Genetic Background: involves: 129S1/Sv

 MP:0003574 abnormal oviduct morphology "malformation of the tube through which the ova pass from the ovary to the uterus" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Wnt7atm1Amc/Wnt7atm1Amc
Genetic Background: involves: 129S1/Sv

 MP:0003826 abnormal Mullerian duct morphology "malformation of the transient embryonic tubes that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

Allelic Composition: Wnt7atm1Amc/Wnt7atm1Amc
Genetic Background: involves: 129S1/Sv

 MP:0004342 scapular bone foramen "presence of a hole in either or both of the large, flat bones of the back part of the shoulder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Wnt7apx-2J/Wnt7apx-2J
Genetic Background: B6;C3Fe-Wnt7apx-2J/GrsrJ

 MP:0004360 absent ulna "missing the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Wnt7atm1Amc/Wnt7atm1Amc
Genetic Background: involves: 129S1/Sv

 MP:0005108 abnormal ulna morphology "malformation of the medial and larger of the two bones of the forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

Allelic Composition: Wnt7apx-r/Wnt7apx-r
Genetic Background: HR

 MP:0005167 abnormal blood-brain barrier "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nbntm3Jpt/Nbntm3Jpt
Genetic Background: involves: 129/Sv

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Wnt7atm1Amc/Wnt7atm1Amc,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005296 abnormal humerus morphology "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Wnt7apx-2J/Wnt7apx-2J
Genetic Background: B6;C3Fe-Wnt7apx-2J/GrsrJ

 MP:0006054 spinal hemorrhage "bleeding into the spine" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nbntm3Jpt/Nbntm3Jpt
Genetic Background: involves: 129/Sv

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Wnt7atm1Amc/Wnt7atm1Amc,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt7apx-J/Wnt7apx-J
Genetic Background: C57BL/6J-Wnt7apx-J/GrsrJ

 MP:0008257 thin myometrium "reduced thickness of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium" [MESH:A02.633.570.500, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt7atm1Amc/Wnt7atm1Amc
Genetic Background: involves: 129S1/Sv

 MP:0008730 fused phalanges "anomaly of the long bones of the digits resulting in some or all the bones being joined together" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt7apx-2J/Wnt7apx-2J
Genetic Background: B6;C3Fe-Wnt7apx-2J/GrsrJ

 MP:0008985 hemimelia "congenital absence of part of an extremity, such as absent fibula with the tibia present" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Wnt7apx-r/Wnt7apx-r
Genetic Background: HR

Allelic Composition: Wnt7apx-J/Wnt7apx-J
Genetic Background: C57BL/6J-Wnt7apx-J/GrsrJ

Allelic Composition: Wnt7apx-2J/Wnt7apx-2J
Genetic Background: B6;C3Fe-Wnt7apx-2J/GrsrJ

 MP:0009071 short oviduct "length reduction or truncation of the tube through which the ova pass from the ovary to the uterus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt7atm1Amc/Wnt7atm1Amc
Genetic Background: involves: 129S1/Sv

 MP:0009081 thin uterus "reduced thickness or depth of the female muscular organ of gestation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt7atm1Amc/Wnt7atm1Amc
Genetic Background: involves: 129S1/Sv

 MP:0009097 absent endometrial glands "absence of the simple or branched tubular uterine glands" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt7atm1Amc/Wnt7atm1Amc
Genetic Background: involves: 129S1/Sv

Allelic Composition: Wnt7atm1.1Tesp/Wnt7atm1.1Tesp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL

 MP:0009139 failure of Mullerian duct regression "failure of the transient embryonic paramesonephric ducts, which normally develop into the oviduct, uterus, cervix and upper vagina in the female, to regress in the male; persistence of Mullerian ducts is typically consistent with a loss of anti-Mullerian hormone signaling and may allow development of the female reproductive tract in males" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt7atm1Amc/Wnt7atm1Amc
Genetic Background: involves: 129S1/Sv

 MP:0009669 abnormal postimplantation uterine environment "failure of the uterus to undergo the changes necessary to support pregnancy following implantation of the embryo" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:10882512 "Carson DD, et al, Embryo implantation Dev Biol. 2000 Jul 15;223(2):217-37."]
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Allelic Composition: Wnt7atm1.1Tesp/Wnt7atm1.1Tesp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL

 MP:0009931 abnormal skin appearance "skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt7apx-2J/Wnt7apx-2J
Genetic Background: B6;C3Fe-Wnt7apx-2J/GrsrJ

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: En1tm1Alj/En1tm1Alj,Wnt7atm1Amc/Wnt7atm1Amc,Tg(Wnt1-En1)1Amc/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Nbntm3Jpt/Nbntm3Jpt
Genetic Background: involves: 129/Sv

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Wnt7atm1Amc/Wnt7atm1Amc,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Smn1tm4(SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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