ENSMUSG00000022382


Mus musculus

Features
Gene ID: ENSMUSG00000022382
  
Biological name :Wnt7b
  
Synonyms : P28047 / wingless-type MMTV integration site family, member 7B / Wnt7b
  
Possible biological names infered from orthology : P56706 / Wnt family member 7B
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E2
Gene start: 85535437
Gene end: 85582473
  
Corresponding Affymetrix probe sets: 10431210 (MoGene1.0st)   1420891_at (Mouse Genome 430 2.0 Array)   1420892_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105051
Ensembl peptide - ENSMUSP00000155014
Ensembl peptide - ENSMUSP00000155817
Ensembl peptide - ENSMUSP00000023015
Ensembl peptide - ENSMUSP00000130627
NCBI entrez gene - 22422     See in Manteia.
MGI - MGI:98962
RefSeq - NM_001163633
RefSeq - NM_001163634
RefSeq - NM_009528
RefSeq Peptide - NP_001157105
RefSeq Peptide - NP_001157106
RefSeq Peptide - NP_033554
swissprot - Q6NZR1
swissprot - E9Q5E3
swissprot - P28047
Ensembl - ENSMUSG00000022382
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnt7baENSDARG00000022858Danio rerio
 wnt7bbENSDARG00000071107Danio rerio
 WNT7BENSGALG00000036255Gallus gallus
 WNT7BENSG00000188064Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wnt7a / P24383 / wingless-type MMTV integration site family, member 7A / O00755* / Wnt family member 7A*ENSMUSG0000003009377
Wnt2b / O70283 / wingless-type MMTV integration site family, member 2B / Q93097* / Wnt family member 2B*ENSMUSG0000002784049
Wnt5b / P22726 / wingless-type MMTV integration site family, member 5B / Q9H1J7* / Wnt family member 5B*ENSMUSG0000003017046
Wnt2 / P21552 / wingless-type MMTV integration site family, member 2 / P09544* / Wnt family member 2*ENSMUSG0000001079745
Wnt4 / P22724 / wingless-type MMTV integration site family, member 4 / P56705* / Wnt family member 4*ENSMUSG0000003685645
Wnt5a / P22725 / wingless-type MMTV integration site family, member 5A / P41221* / Wnt family member 5A*ENSMUSG0000002199445
Wnt3 / P17553 / wingless-type MMTV integration site family, member 3 / P56703* / Wnt family member 3*ENSMUSG0000000012544
Wnt16 / Q9QYS1 / wingless-type MMTV integration site family, member 16 / Q9UBV4* / Wnt family member 16*ENSMUSG0000002967143
Wnt3a / P27467 / wingless-type MMTV integration site family, member 3A / P56704* / Wnt family member 3A*ENSMUSG0000000990043
Wnt6 / P22727 / wingless-type MMTV integration site family, member 6 / Q9Y6F9* / Wnt family member 6*ENSMUSG0000003322739
Wnt1 / P04426 / wingless-type MMTV integration site family, member 1 / P04628* / Wnt family member 1*ENSMUSG0000002299737
Wnt11 / P48615 / wingless-type MMTV integration site family, member 11 / O96014* / Wnt family member 11*ENSMUSG0000001595735


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR013300  Wnt-7 protein
 IPR018161  Wnt protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0003338 metanephros morphogenesis IMP
 biological_processGO:0007257 activation of JUN kinase activity IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016332 establishment or maintenance of polarity of embryonic epithelium IMP
 biological_processGO:0021846 cell proliferation in forebrain IDA
 biological_processGO:0021871 forebrain regionalization IEP
 biological_processGO:0022009 central nervous system vasculogenesis IGI
 biological_processGO:0030182 neuron differentiation IEP
 biological_processGO:0030324 lung development IMP
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0032364 oxygen homeostasis IMP
 biological_processGO:0032536 regulation of cell projection size IDA
 biological_processGO:0036516 chemoattraction of dopaminergic neuron axon IDA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IMP
 biological_processGO:0042592 homeostatic process IMP
 biological_processGO:0044237 cellular metabolic process IMP
 biological_processGO:0045165 cell fate commitment IBA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IDA
 biological_processGO:0045879 negative regulation of smoothened signaling pathway IMP
 biological_processGO:0046330 positive regulation of JNK cascade IMP
 biological_processGO:0048144 fibroblast proliferation IEP
 biological_processGO:0048568 embryonic organ development IMP
 biological_processGO:0048812 neuron projection morphogenesis IDA
 biological_processGO:0048864 stem cell development IDA
 biological_processGO:0050768 negative regulation of neurogenesis IDA
 biological_processGO:0050808 synapse organization IGI
 biological_processGO:0051145 smooth muscle cell differentiation IMP
 biological_processGO:0051384 response to glucocorticoid IEP
 biological_processGO:0060033 anatomical structure regression IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IDA
 biological_processGO:0060425 lung morphogenesis IMP
 biological_processGO:0060428 lung epithelium development IMP
 biological_processGO:0060482 lobar bronchus development IMP
 biological_processGO:0060484 lung-associated mesenchyme development IMP
 biological_processGO:0060535 trachea cartilage morphogenesis IMP
 biological_processGO:0060560 developmental growth involved in morphogenesis IMP
 biological_processGO:0060669 embryonic placenta morphogenesis IMP
 biological_processGO:0060710 chorio-allantoic fusion IMP
 biological_processGO:0061180 mammary gland epithelium development IEP
 biological_processGO:0071300 cellular response to retinoic acid IEP
 biological_processGO:0072053 renal inner medulla development IMP
 biological_processGO:0072054 renal outer medulla development IMP
 biological_processGO:0072060 outer medullary collecting duct development IMP
 biological_processGO:0072061 inner medullary collecting duct development IMP
 biological_processGO:0072089 stem cell proliferation IEP
 biological_processGO:0072205 metanephric collecting duct development IMP
 biological_processGO:0072207 metanephric epithelium development IMP
 biological_processGO:0072236 metanephric loop of Henle development IMP
 biological_processGO:1902262 apoptotic process involved in blood vessel morphogenesis IMP
 biological_processGO:1904938 planar cell polarity pathway involved in axon guidance IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005109 frizzled binding IPI
 molecular_functionGO:0048018 receptor ligand activity IDA
 molecular_functionGO:1902379 chemoattractant activity involved in axon guidance IDA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000536 hydroureter "distention of the ureter with urine, due to blockage from any cause" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:Cml, J:13044]
Show

Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Dlk1tm1Hsul/Dlk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Rpl38Ts/Rpl38+
Genetic Background: (TSJ/Le x AKR/J)F1

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rpl38Ts/Rpl38+
Genetic Background: (TSJ/Le x AKR/J)F1

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
Show

Allelic Composition: Dlk1tm1Hsul/Dlk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
Show

Allelic Composition: Dlk1tm1Hsul/Dlk1+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
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Allelic Composition: Wnt7btm2.1Amc/Wnt7btm2.1Amc
Genetic Background: involves: 129X1/SvJ

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nbntm3Jpt/Nbntm3Jpt
Genetic Background: involves: 129/Sv

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Wnt7atm1Amc/Wnt7atm1Amc,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nbntm3Jpt/Nbntm3Jpt
Genetic Background: involves: 129/Sv

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Wnt7atm1Amc/Wnt7atm1Amc,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Dlk1tm1Hsul/Dlk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rpl38Ts/Rpl38+
Genetic Background: (TSJ/Le x AKR/J)F1

Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002824 abnormal chorioallantoic fusion "abnormal process of or failure of the formation of the membrane that forms the fetal portion of the placenta; derived from the fusion of the chorion and the allantois" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002836 abnormal chorion "malformations of the outermost extraembryonic membrane" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003120 abnormal tracheal cartilage "any structural anomaly of the cartilaginous structures that support the trachea" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:97123]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003613 abnormal kidney medulla development 
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
Show

Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlk1tm1Hsul/Dlk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0004860 dilated kidney collecting duct "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005167 abnormal blood-brain barrier "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nbntm3Jpt/Nbntm3Jpt
Genetic Background: involves: 129/Sv

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Wnt7atm1Amc/Wnt7atm1Amc,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005631 decreased lung weight "less than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0006054 spinal hemorrhage "bleeding into the spine" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nbntm3Jpt/Nbntm3Jpt
Genetic Background: involves: 129/Sv

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Wnt7atm1Amc/Wnt7atm1Amc,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008395 abnormal osteoblast differentiation "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt7btm2.1Amc/Wnt7btm2.1Amc
Genetic Background: involves: 129X1/SvJ

 MP:0009573 abnormal right lung middle lobe morphology 
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0010816 decreased type I pneumocyte number "reduced number of the flattened, branched squamous cells that covers more than 98 percent of the alveolar surface, and have thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange" [PMID:20054144]
Show

Allelic Composition: Dlk1tm1Hsul/Dlk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Dlk1tm1Hsul/Dlk1+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Wnt7btm2.1Amc/Wnt7btm2.1Amc
Genetic Background: involves: 129X1/SvJ

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Wnt7btm2.1Amc/Wnt7btm2.1Amc
Genetic Background: involves: 129X1/SvJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Nbntm3Jpt/Nbntm3Jpt
Genetic Background: involves: 129/Sv

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Wnt7atm1Amc/Wnt7atm1Amc,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011144 thin lung-associated mesenchyme "decreased thickness of the mesenchymal cell layer in the developing lung" [MGI:anna]
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Allelic Composition: Dlk1tm1Hsul/Dlk1+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0011146 abnormal mesenchymal cell proliferation involved in lung development "anomaly in the ability of the differentiating lung mesenchymal cell population to undergo expansion by cell division in the developing lung" [MGI:anna]
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Allelic Composition: Dlk1tm1Hsul/Dlk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0011148 decreased mesenchymal cell proliferation involved in lung development "reduction in the expansion rate of a lung mesenchymal cell population by cell division" [MGI:anna]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0011345 truncated loop of Henle "failure of the developing loop of Henle to elongate and extend into the medullary zone of the kidney" [MGI:anna]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0011438 absent kidney medulla "failure of the inner portion of the kidney, normally consisting of the renal pyramids, to form" [MGI:anna]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011439 abnormal kidney cell proliferation "anomaly in the ability of any kidney cell population to undergo expansion by cell division" [MGI:anna]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0011441 decreased kidney cell proliferation "decrease in the expansion rate of any kidney cell population by cell division" [MGI:anna]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0011843 abnormal kidney collecting duct epithelium morphology "any structural anomaly of the simple cuboidal epithelium lining the lumen of kidney collecting ducts; the mature and differentiated CD epithelium comprises two unique cells types with principal cells responsible for vasopressin-regulated water reabsorption, and intercalated cells regulating acid-base homeostasis; injury to the epithelium is believed to cause epithelial cells to acquire mesenchymal characteristics via epithelial-mesenchymal transition (EMT), a process through which tubular epithelial cells may transform into interstitial fibroblasts and promote renal fibrosis" [MGI:anna]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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