ENSMUSG00000015957


Mus musculus

Features
Gene ID: ENSMUSG00000015957
  
Biological name :Wnt11
  
Synonyms : P48615 / wingless-type MMTV integration site family, member 11 / Wnt11
  
Possible biological names infered from orthology : O96014 / Wnt family member 11
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E1
Gene start: 98835112
Gene end: 98855195
  
Corresponding Affymetrix probe sets: 10555186 (MoGene1.0st)   1450772_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132166
Ensembl peptide - ENSMUSP00000125789
Ensembl peptide - ENSMUSP00000126428
Ensembl peptide - ENSMUSP00000131770
Ensembl peptide - ENSMUSP00000064333
NCBI entrez gene - 22411     See in Manteia.
MGI - MGI:101948
RefSeq - XM_011241733
RefSeq - NM_001285792
RefSeq - NM_001285794
RefSeq - NM_001285795
RefSeq - NM_009519
RefSeq - XM_006507586
RefSeq - XM_006507587
RefSeq Peptide - NP_033545
RefSeq Peptide - NP_001272723
RefSeq Peptide - NP_001272724
RefSeq Peptide - NP_001272721
swissprot - Q059Y4
swissprot - E9PVI8
swissprot - E9Q692
swissprot - E9PYZ1
swissprot - P48615
Ensembl - ENSMUSG00000015957
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnt11rENSDARG00000014796Danio rerio
 WNT11ENSGALG00000000839Gallus gallus
 WNT11ENSG00000085741Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wnt5b / P22726 / wingless-type MMTV integration site family, member 5B / Q9H1J7* / Wnt family member 5B*ENSMUSG0000003017038
Wnt5a / P22725 / wingless-type MMTV integration site family, member 5A / P41221* / Wnt family member 5A*ENSMUSG0000002199438
Wnt16 / Q9QYS1 / wingless-type MMTV integration site family, member 16 / Q9UBV4* / Wnt family member 16*ENSMUSG0000002967137
Wnt4 / P22724 / wingless-type MMTV integration site family, member 4 / P56705* / Wnt family member 4*ENSMUSG0000003685637
Wnt2b / O70283 / wingless-type MMTV integration site family, member 2B / Q93097* / Wnt family member 2B*ENSMUSG0000002784037
Wnt7a / P24383 / wingless-type MMTV integration site family, member 7A / O00755* / Wnt family member 7A*ENSMUSG0000003009336
Wnt7b / P28047 / wingless-type MMTV integration site family, member 7B / P56706* / Wnt family member 7B*ENSMUSG0000002238235
Wnt3 / P17553 / wingless-type MMTV integration site family, member 3 / P56703* / Wnt family member 3*ENSMUSG0000000012535
Wnt2 / P21552 / wingless-type MMTV integration site family, member 2 / P09544* / Wnt family member 2*ENSMUSG0000001079735
Wnt6 / P22727 / wingless-type MMTV integration site family, member 6 / Q9Y6F9* / Wnt family member 6*ENSMUSG0000003322734
Wnt1 / P04426 / wingless-type MMTV integration site family, member 1 / P04628* / Wnt family member 1*ENSMUSG0000002299734
Wnt3a / P27467 / wingless-type MMTV integration site family, member 3A / P56704* / Wnt family member 3A*ENSMUSG0000000990034


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR018161  Wnt protein, conserved site
 IPR026536  Wnt-11 protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IGI
 biological_processGO:0001822 kidney development IDA
 biological_processGO:0001837 epithelial to mesenchymal transition IGI
 biological_processGO:0003151 outflow tract morphogenesis IMP
 biological_processGO:0003402 planar cell polarity pathway involved in axis elongation IGI
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0030282 bone mineralization IGI
 biological_processGO:0030308 negative regulation of cell growth ISS
 biological_processGO:0030325 adrenal gland development IEA
 biological_processGO:0030335 positive regulation of cell migration ISS
 biological_processGO:0030336 negative regulation of cell migration ISS
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032915 positive regulation of transforming growth factor beta2 production IMP
 biological_processGO:0034394 protein localization to cell surface ISS
 biological_processGO:0035567 non-canonical Wnt signaling pathway IMP
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0043547 positive regulation of GTPase activity ISS
 biological_processGO:0045165 cell fate commitment IBA
 biological_processGO:0045199 maintenance of epithelial cell apical/basal polarity IGI
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0048341 paraxial mesoderm formation IGI
 biological_processGO:0048570 notochord morphogenesis IGI
 biological_processGO:0048706 embryonic skeletal system development IEA
 biological_processGO:0048844 artery morphogenesis IMP
 biological_processGO:0051496 positive regulation of stress fiber assembly ISO
 biological_processGO:0060021 roof of mouth development ISS
 biological_processGO:0060028 convergent extension involved in axis elongation IGI
 biological_processGO:0060070 canonical Wnt signaling pathway IDA
 biological_processGO:0060197 cloacal septation IEA
 biological_processGO:0060412 ventricular septum morphogenesis IMP
 biological_processGO:0060484 lung-associated mesenchyme development IEA
 biological_processGO:0060548 negative regulation of cell death ISS
 biological_processGO:0060675 ureteric bud morphogenesis IEA
 biological_processGO:0060775 planar cell polarity pathway involved in gastrula mediolateral intercalation IGI
 biological_processGO:0061053 somite development IGI
 biological_processGO:0061101 neuroendocrine cell differentiation ISO
 biological_processGO:0070830 bicellular tight junction assembly IMP
 biological_processGO:0071260 cellular response to mechanical stimulus IDA
 biological_processGO:0072177 mesonephric duct development IEA
 biological_processGO:0072201 negative regulation of mesenchymal cell proliferation IMP
 biological_processGO:0090037 positive regulation of protein kinase C signaling ISS
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway ISS
 biological_processGO:0090272 negative regulation of fibroblast growth factor production IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm ISS
 molecular_functionGO:0005096 GTPase activator activity ISO
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005109 frizzled binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030295 protein kinase activator activity ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISS


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking
Ca2+ pathway
PCP/CE pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt3atm1Amc/Wnt3a+
Genetic Background: involves: 129 * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt11tm1Amc/Wnt11+
Genetic Background: involves: 129 * C57BL/6

 MP:0000528 delayed kidney development "late onset of the induction and/or differentiation of the kidney" [J:18048]
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Allelic Composition: Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Rettm1Cos/Ret+,Wnt11tm1Amc/Wnt11+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * MF1

Allelic Composition: Rettm1Cos/Ret+,Wnt11tm1Amc/Wnt11tm1Amc
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * MF1

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Rettm1Cos/Ret+,Wnt11tm1Amc/Wnt11tm1Amc
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * MF1

 MP:0009671 abnormal uterus physiology "any anomaly in normal cyclical changes not due to anatomical defect" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif5btm1Njen/Kif5b+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6N * DBA * SJL

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt11tm1Amc/Wnt11+
Genetic Background: involves: 129 * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0011760 abnormal ureteric bud tip morphology "any structural anomaly of the terminal ends of the ureteric tree; the ureteric tip cells are proliferating immature cells located at the branching points that induce the adjacent cap mesenchyme to undergo nephrogenesis" [MGI:anna]
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Allelic Composition: Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0013401 increased endometrial gland number "greater than normal numbers of the simple or branched tubular glands found in the mucus membrane of the uterus" [MGI:Anna]
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Allelic Composition: Wnt11tm1.1Khay/Wnt11tm1.2Khay,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / reaction / complex
 ENSMUSG00000044674 Fzd1 / O70421 / Frizzled-1 / Q9UP38* / frizzled class receptor 1*  / complex
 ENSMUSG00000041075 Fzd7 / Q61090 / Frizzled-7 / O75084* / frizzled class receptor 7*  / complex






 

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