ENSMUSG00000044674


Mus musculus

Features
Gene ID: ENSMUSG00000044674
  
Biological name :Fzd1
  
Synonyms : Frizzled-1 / Fzd1 / O70421
  
Possible biological names infered from orthology : frizzled class receptor 1 / Q9UP38
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: A1
Gene start: 4753839
Gene end: 4758035
  
Corresponding Affymetrix probe sets: 10527936 (MoGene1.0st)   1422985_at (Mouse Genome 430 2.0 Array)   1437284_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000058629
NCBI entrez gene - 14362     See in Manteia.
MGI - MGI:1196625
RefSeq - NM_021457
RefSeq Peptide - NP_067432
swissprot - O70421
Ensembl - ENSMUSG00000044674
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fzd1ENSDARG00000106062Danio rerio
 FZD1ENSGALG00000009064Gallus gallus
 FZD1ENSG00000157240Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fzd2 / Q9JIP6 / Frizzled-2 / Q14332* / frizzled class receptor 2*ENSMUSG0000005028870
Fzd7 / Q61090 / Frizzled-7 / O75084* / frizzled class receptor 7*ENSMUSG0000004107569
Fzd5 / Q9EQD0 / Frizzled-5 / Q13467* / frizzled class receptor 5*ENSMUSG0000004500542
Fzd8 / Q61091 / Frizzled-8 / Q9H461* / frizzled class receptor 8*ENSMUSG0000003690442
Fzd10 / Q8BKG4 / Frizzled-10 / Q9ULW2* / frizzled class receptor 10*ENSMUSG0000008168340
Fzd9 / Q9R216 / Frizzled-9 / O00144* / frizzled class receptor 9*ENSMUSG0000004955139
Fzd3 / Q61086 / Frizzled-3 / Q9NPG1* / frizzled class receptor 3*ENSMUSG0000000798938
Fzd4 / Q61088 / Frizzled-4 / Q9ULV1* / frizzled class receptor 4*ENSMUSG0000004979137
Fzd6 / Q61089 / Frizzled-6 / O60353* / frizzled class receptor 6*ENSMUSG0000002229736
Smo / P56726 / smoothened, frizzled class receptor / Q99835*ENSMUSG0000000176123
Sfrp4 / Q9Z1N6 / secreted frizzled-related protein 4 / Q6FHJ7*ENSMUSG0000002131914
Sfrp1 / Q8C4U3 / Secreted frizzled-related protein 1 / Q8N474*ENSMUSG0000003154814
Sfrp5 / secreted frizzled-related sequence protein 5 / Q5T4F7* / secreted frizzled related protein 5*ENSMUSG0000001882213
Frzb / P97401 / Secreted frizzled-related protein 3 / Q92765* / frizzled related protein*ENSMUSG0000002700413
Sfrp2 / P97299 / secreted frizzled-related protein 2 / Q96HF1*ENSMUSG0000002799612


Protein motifs (from Interpro)
Interpro ID Name
 IPR000539  Frizzled/Smoothened, transmembrane domain
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR017981  GPCR, family 2-like
 IPR020067  Frizzled domain
 IPR026548  Frizzled-1
 IPR036790  Frizzled cysteine-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0003149 membranous septum morphogenesis IGI
 biological_processGO:0003150 muscular septum morphogenesis IGI
 biological_processGO:0003151 outflow tract morphogenesis IGI
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016055 Wnt signaling pathway IGI
 biological_processGO:0030514 negative regulation of BMP signaling pathway IDA
 biological_processGO:0030855 epithelial cell differentiation IGI
 biological_processGO:0035425 autocrine signaling IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0044338 canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation IEA
 biological_processGO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0060022 hard palate development IGI
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060412 ventricular septum morphogenesis IGI
 biological_processGO:0090179 planar cell polarity pathway involved in neural tube closure IGI
 biological_processGO:1903204 negative regulation of oxidative stress-induced neuron death IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005109 frizzled binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017147 Wnt-protein binding IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0042813 Wnt-activated receptor activity ISO


Pathways (from Reactome)
Pathway description
PCP/CE pathway
Asymmetric localization of PCP proteins
Disassembly of the destruction complex and recruitment of AXIN to the membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Fzd1tm1.1Nat/Fzd1tm1.1Nat,Fzd2tm1.1Nat/Fzd2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Fzd1tm1.1Nat/Fzd1tm1.1Nat,Fzd2tm1.1Nat/Fzd2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Fzd1tm1.1Nat/Fzd1+,Fzd2tm1.1Nat/Fzd2tm1.1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000273 overriding aorta "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000452 abnormal mouth morphology "anomalous structure or development of the oral cavity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Fzd1tm1.1Nat/Fzd1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ

Allelic Composition: Fzd1tm1.1Nat/Fzd1+,Fzd2tm1.1Nat/Fzd2+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Srgap3tm1.1Zi/Srgap3tm1.1Zi
Genetic Background: B6.129(SJL)-Srgap3tm1.1Zi

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Srgap3tm1.1Zi/Srgap3tm1.1Zi
Genetic Background: B6.129(SJL)-Srgap3tm1.1Zi

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Srgap3tm1.1Zi/Srgap3tm1.1Zi
Genetic Background: B6.129(SJL)-Srgap3tm1.1Zi

 MP:0001132 absent mature ovarian follicles "failure of ovarian follicle differentiation" [J:35782]
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Allelic Composition: Srgap3tm1.1Zi/Srgap3tm1.1Zi
Genetic Background: B6.129(SJL)-Srgap3tm1.1Zi

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Srgap3tm1.1Zi/Srgap3tm1.1Zi
Genetic Background: B6.129(SJL)-Srgap3tm1.1Zi

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Srgap3tm1.1Zi/Srgap3tm1.1Zi
Genetic Background: B6.129(SJL)-Srgap3tm1.1Zi

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Srgap3tm1.1Zi/Srgap3tm1.1Zi
Genetic Background: B6.129(SJL)-Srgap3tm1.1Zi

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntsr1tm1Dgen/Ntsr1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0004406 abnormal cochlear hair cell number "abnormal number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0004491 abnormal orientation of outer hair cell stereociliary bundles "misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0009094 abnormal endometrial gland morphology "any structural anomaly of the numerous simple or branched tubular glands lined by ciliated columnar epithelium and found in the mucus membrane of the uterus which secrete mucus, lipids, glycogen, and protein; endometrial glands and their secretions (termed histotroph) are critical regulators of peri-implantation embryo survival and implantation as well as establishment of uterine receptivity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Srgap3tm1.1Zi/Srgap3tm1.1Zi
Genetic Background: B6.129(SJL)-Srgap3tm1.1Zi

 MP:0009096 decreased endometrial gland number "fewer than normal numbers of the simple or branched tubular glands found in the mucus membrane of the uterus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Srgap3tm1.1Zi/Srgap3tm1.1Zi
Genetic Background: B6.129(SJL)-Srgap3tm1.1Zi

 MP:0009653 abnormal palate development "abnormal formation of the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0009886 failure of palatal shelf elevation "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Fzd1tm1.1Nat/Fzd1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ

Allelic Composition: Fzd1tm1.1Nat/Fzd1+,Fzd2tm1.1Nat/Fzd2+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003233 Dvl3 / Q61062 / Segment polarity DVL-3 / Q92997* / dishevelled segment polarity protein 3*  / complex
 ENSMUSG00000009900 Wnt3a / P27467 / wingless-type MMTV integration site family, member 3A / P56704* / Wnt family member 3A*  / complex
 ENSMUSG00000012282 Wnt8a / Q64527 / wingless-type MMTV integration site family, member 8A / Q9H1J5* / Wnt family member 8A*  / complex
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / complex / reaction
 ENSMUSG00000022997 Wnt1 / P04426 / wingless-type MMTV integration site family, member 1 / P04628* / Wnt family member 1*  / complex
 ENSMUSG00000030201 Lrp6 / LDL receptor related protein 6 / O75581*  / complex
 ENSMUSG00000036961 Wnt8b / wingless-type MMTV integration site family, member 8B / Q93098* / Wnt family member 8B*  / complex
 ENSMUSG00000029071 Dvl1 / P51141 / Segment polarity DVL-1 / O14640* / dishevelled segment polarity protein 1*  / complex
 ENSMUSG00000024182 Axin1 / O15169*  / complex / reaction
 ENSMUSG00000022812 Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*  / reaction / complex
 ENSMUSG00000015957 Wnt11 / P48615 / wingless-type MMTV integration site family, member 11 / O96014* / Wnt family member 11*  / complex






 

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