ENSMUSG00000009900


Mus musculus

Features
Gene ID: ENSMUSG00000009900
  
Biological name :Wnt3a
  
Synonyms : P27467 / wingless-type MMTV integration site family, member 3A / Wnt3a
  
Possible biological names infered from orthology : P56704 / Wnt family member 3A
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.3
Gene start: 59248033
Gene end: 59290752
  
Corresponding Affymetrix probe sets: 10386376 (MoGene1.0st)   1422093_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000010044
NCBI entrez gene - 22416     See in Manteia.
MGI - MGI:98956
RefSeq - NM_009522
RefSeq Peptide - NP_033548
swissprot - P27467
Ensembl - ENSMUSG00000009900
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnt3aENSDARG00000058822Danio rerio
 WNT3AENSGALG00000042657Gallus gallus
 WNT3AENSG00000154342Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wnt3 / P17553 / wingless-type MMTV integration site family, member 3 / P56703* / Wnt family member 3*ENSMUSG0000000012584
Wnt4 / P22724 / wingless-type MMTV integration site family, member 4 / P56705* / Wnt family member 4*ENSMUSG0000003685646
Wnt5b / P22726 / wingless-type MMTV integration site family, member 5B / Q9H1J7* / Wnt family member 5B*ENSMUSG0000003017045
Wnt5a / P22725 / wingless-type MMTV integration site family, member 5A / P41221* / Wnt family member 5A*ENSMUSG0000002199445
Wnt1 / P04426 / wingless-type MMTV integration site family, member 1 / P04628* / Wnt family member 1*ENSMUSG0000002299743
Wnt7b / P28047 / wingless-type MMTV integration site family, member 7B / P56706* / Wnt family member 7B*ENSMUSG0000002238243
Wnt7a / P24383 / wingless-type MMTV integration site family, member 7A / O00755* / Wnt family member 7A*ENSMUSG0000003009342
Wnt2 / P21552 / wingless-type MMTV integration site family, member 2 / P09544* / Wnt family member 2*ENSMUSG0000001079742
Wnt6 / P22727 / wingless-type MMTV integration site family, member 6 / Q9Y6F9* / Wnt family member 6*ENSMUSG0000003322741
Wnt2b / O70283 / wingless-type MMTV integration site family, member 2B / Q93097* / Wnt family member 2B*ENSMUSG0000002784041
Wnt16 / Q9QYS1 / wingless-type MMTV integration site family, member 16 / Q9UBV4* / Wnt family member 16*ENSMUSG0000002967141
Wnt11 / P48615 / wingless-type MMTV integration site family, member 11 / O96014* / Wnt family member 11*ENSMUSG0000001595734


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR009141  Wnt-3 protein
 IPR018161  Wnt protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IGI
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0001819 positive regulation of cytokine production IDA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0002092 positive regulation of receptor internalization IEA
 biological_processGO:0003136 negative regulation of heart induction by canonical Wnt signaling pathway IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007409 axonogenesis IGI
 biological_processGO:0007411 axon guidance IDA
 biological_processGO:0007498 mesoderm development IMP
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0009952 anterior/posterior pattern specification IDA
 biological_processGO:0010387 COP9 signalosome assembly IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010977 negative regulation of neuron projection development IDA
 biological_processGO:0016055 Wnt signaling pathway IGI
 biological_processGO:0021527 spinal cord association neuron differentiation IGI
 biological_processGO:0021766 hippocampus development IMP
 biological_processGO:0021846 cell proliferation in forebrain IDA
 biological_processGO:0021874 Wnt signaling pathway involved in forebrain neuroblast division IMP
 biological_processGO:0021904 dorsal/ventral neural tube patterning IMP
 biological_processGO:0022008 neurogenesis IDA
 biological_processGO:0030097 hemopoiesis IDA
 biological_processGO:0030168 platelet activation IDA
 biological_processGO:0030198 extracellular matrix organization IDA
 biological_processGO:0030509 BMP signaling pathway ISO
 biological_processGO:0030879 mammary gland development IDA
 biological_processGO:0030890 positive regulation of B cell proliferation IDA
 biological_processGO:0030901 midbrain development IDA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0033278 cell proliferation in midbrain IDA
 biological_processGO:0034613 cellular protein localization IDA
 biological_processGO:0035914 skeletal muscle cell differentiation IGI
 biological_processGO:0036342 post-anal tail morphogenesis IMP
 biological_processGO:0042472 inner ear morphogenesis IGI
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0045595 regulation of cell differentiation IDA
 biological_processGO:0045599 negative regulation of fat cell differentiation IGI
 biological_processGO:0045860 positive regulation of protein kinase activity IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048103 somatic stem cell division IDA
 biological_processGO:0048337 positive regulation of mesodermal cell fate specification IEA
 biological_processGO:0048343 paraxial mesodermal cell fate commitment IMP
 biological_processGO:0048643 positive regulation of skeletal muscle tissue development IMP
 biological_processGO:0048697 positive regulation of collateral sprouting in absence of injury IDA
 biological_processGO:0048843 negative regulation of axon extension involved in axon guidance IDA
 biological_processGO:0050768 negative regulation of neurogenesis IDA
 biological_processGO:0050770 regulation of axonogenesis IGI
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060923 cardiac muscle cell fate commitment IGI
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IGI
 biological_processGO:0061184 positive regulation of dermatome development IEA
 biological_processGO:0061317 canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment IEA
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IGI
 biological_processGO:0070527 platelet aggregation IDA
 biological_processGO:0071542 dopaminergic neuron differentiation TAS
 biological_processGO:0090245 axis elongation involved in somitogenesis IGI
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090676 calcium ion transmembrane transport via low voltage-gated calcium channel IDA
 biological_processGO:1901215 negative regulation of neuron death IGI
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IDA
 biological_processGO:1904339 negative regulation of dopaminergic neuron differentiation IDA
 biological_processGO:1904798 positive regulation of core promoter binding IMP
 biological_processGO:2000049 positive regulation of cell-cell adhesion mediated by cadherin IDA
 biological_processGO:2000081 positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation IDA
 biological_processGO:2000179 positive regulation of neural precursor cell proliferation IDA
 biological_processGO:2000347 positive regulation of hepatocyte proliferation IDA
 biological_processGO:2000727 positive regulation of cardiac muscle cell differentiation IEA
 biological_processGO:2001141 regulation of RNA biosynthetic process IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:1990851 Wnt-Frizzled-LRP5/6 complex IEA
 cellular_componentGO:1990909 Wnt signalosome NAS
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005109 frizzled binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0039706 co-receptor binding IEA
 molecular_functionGO:0048018 receptor ligand activity IEA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Regulation of FZD by ubiquitination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pkd1tm1Hung/Pkd1tm1Hung
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt3atm1Amc/Wnt3a+
Genetic Background: involves: 129 * C57BL/6

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Plxnb2m597804Hubr/Plxnb2m597804Hubr
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt3atm1Amc/Wnt3a+
Genetic Background: involves: 129 * C57BL/6

 MP:0000344 absent Cajal-Retzius cell "the absence of a distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus" [J:60896, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Pkd1tm1Hung/Pkd1tm1Hung
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Wnt3avt/Wnt3avt
Genetic Background: involves: C3H/HeJ * C57BL/6J * C57BR

 MP:0000557 absent hindlimb "missing the entire posterior extremities" [MGI:tc, J:54637]
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Allelic Composition: Plxnb2m597804Hubr/Plxnb2m597804Hubr
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6+,Wnt3avt/Wnt3a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BR

 MP:0000737 abnormal myotome development "malformation of or absence of the part of the somite that develops into the musculature" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29279]
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 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Wnt3atm1Amc/Wnt3avt
Genetic Background: involves: 129S1/Sv * C3H/HeJ * C57BL/6J * C57BR

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Wnt3atm2Eag/Wnt3a+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Tg(Otx1-cre)1Eag/0,Wnt3atm2Eag/Wnt3a+
Genetic Background: Not Specified

 MP:0000792 abnormal cortical marginal zone morphology 
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Allelic Composition: Tg(Otx1-cre)1Eag/0,Wnt3atm2Eag/Wnt3a+
Genetic Background: Not Specified

 MP:0000847 abnormal metencephalon morphology "any malformation or absence of the anterior part of the rhombencephalon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp5se-Ca/Bmp5+
Genetic Background: SEACGn.CB-Bmp5se-Ca

 MP:0000964 small dorsal root ganglia "reduced size of the dorsal root ganglia" [J:17123]
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 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp5se-Ca/Bmp5+
Genetic Background: SEACGn.CB-Bmp5se-Ca

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Pkd1tm1Hung/Pkd1tm1Hung
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: PitpnaGt(OST1152)Lex/PitpnaGt(OST1152)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Wnt3avt/Wnt3avt
Genetic Background: involves: C3H/HeJ * C57BL/6J * C57BR

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp5se-Ca/Bmp5+
Genetic Background: SEACGn.CB-Bmp5se-Ca

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Wnt3avt/Wnt3avt
Genetic Background: involves: C3H/HeJ * C57BL/6J * C57BR

Allelic Composition: Wnt3atm1Amc/Wnt3avt
Genetic Background: involves: 129S1/Sv * C3H/HeJ * C57BL/6J * C57BR

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Bmp5se-Ca/Bmp5+
Genetic Background: SEACGn.CB-Bmp5se-Ca

 MP:0001690 failure of somite differentiation "disorganized or absent somite tissue or somite pattern in development" [J:25248]
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Allelic Composition: Plxnb2m597804Hubr/Plxnb2m597804Hubr
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp5se-Ca/Bmp5+
Genetic Background: SEACGn.CB-Bmp5se-Ca

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Wnt3atm1Amc/Wnt3avt
Genetic Background: involves: 129S1/Sv * C3H/HeJ * C57BL/6J * C57BR

 MP:0001704 abnormal dorsal-ventral axis patterning "anomaly in the development or formation of the axis that runs from the front to the back surface of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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 MP:0001756 abnormal urination "anomaly in the production and excretion of urine" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt3avt/Wnt3avt
Genetic Background: involves: C3H/HeJ * C57BL/6J * C57BR

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: PitpnaGt(OST1152)Lex/PitpnaGt(OST1152)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pkd1tm1Hung/Pkd1tm1Hung
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt3avt/Wnt3avt
Genetic Background: involves: C3H/HeJ * C57BL/6J * C57BR

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6+,Wnt3avt/Wnt3a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BR

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6+,Wnt3avt/Wnt3a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BR

 MP:0002260 abnormal thyroid cartilage morphology "any structural anomaly of the largest of the laryngeal cartilages " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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 MP:0002632 vestigial tail "a trace or rudimentary tail structure; the degenerated remains of any tail structure" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: PitpnaGt(OST1152)Lex/PitpnaGt(OST1152)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6+,Wnt3avt/Wnt3avt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BR

Allelic Composition: Wnt3avt/Wnt3avt
Genetic Background: involves: A * A/Gr * C57BR

Allelic Composition: Wnt3avt/Wnt3avt
Genetic Background: involves: C3H/HeJ * C57BL/6J * C57BR

 MP:0002759 abnormal caudal vertebrae morphology "malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]
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Allelic Composition: Wnt3avt/Wnt3avt
Genetic Background: involves: C3H/HeJ * C57BL/6J * C57BR

 MP:0002861 abnormal tail bud morphology "anomalous formation of the primordial region of the embryo that arises to form the tail of the adult; appears approximately ten days following conception as a short stump, and then initiates elongation and thinning in normal development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt3avt/Wnt3avt
Genetic Background: involves: A * A/Gr * C57BR

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Wnt3atm1Amc/Wnt3avt
Genetic Background: involves: 129S1/Sv * C3H/HeJ * C57BL/6J * C57BR

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Wnt3atm1Amc/Wnt3avt
Genetic Background: involves: 129S1/Sv * C3H/HeJ * C57BL/6J * C57BR

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp5se-Ca/Bmp5+
Genetic Background: SEACGn.CB-Bmp5se-Ca

 MP:0003445 sirenomelia "fusion of the posterior limbs often with partial or complete fusion of the autopods" [J:67375]
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Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Wnt3astrtls/Wnt3astrtls
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0003456 absent tail "completely lacking the appendage at the caudal end of the vertebral column " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp5se-Ca/Bmp5+
Genetic Background: SEACGn.CB-Bmp5se-Ca

Allelic Composition: Wnt3atm1Amc/Wnt3avt
Genetic Background: involves: 129S1/Sv * C3H/HeJ * C57BL/6J * C57BR

Allelic Composition: Wnt3astrtls/Wnt3astrtls
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Bmp5se-Ca/Bmp5+
Genetic Background: SEACGn.CB-Bmp5se-Ca

 MP:0003864 abnormal midbrain development "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt3atm1Amc/Wnt3atm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Wnt3astrtls/Wnt3astrtls
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0004204 absent stapes "absence of the smallest and innermost of the three auditory ossicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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 MP:0004205 absent hyoid bone "absence of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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 MP:0004206 abnormal dermomyotome development "any structural anomaly of the portion of the embryonic somite that remains after migration of the sclerotomic tissue" [J:50279, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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 MP:0004459 small alisphenoid bone "reduced size of either of the broad curved wing like expanses on each side of the sphenoid bone in adults; may exist independently in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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 MP:0004462 small basisphenoid bone "reduced size of part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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 MP:0004608 abnormal cervical axis morphology "any structural anomaly of the second cervical vertebra (C2) which forms the pivot upon which the first cervical (atlas, C1) vertebra rotates" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Wnt3avt/Wnt3avt
Genetic Background: B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt3avt/Wnt3avt
Genetic Background: B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J

 MP:0004617 sacral vertebral transformation "homeotic transformation of any sacral vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt3avt/Wnt3avt
Genetic Background: B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt3avt/Wnt3avt
Genetic Background: B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Wnt3atm1Amc/Wnt3avt
Genetic Background: involves: 129S1/Sv * C3H/HeJ * C57BL/6J * C57BR

 MP:0004648 decreased thoracic vertebrae number "reduced number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Wnt3atm1Amc/Wnt3avt
Genetic Background: involves: 129S1/Sv * C3H/HeJ * C57BL/6J * C57BR

 MP:0004656 absent sacral vertebrae "absence of all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Wnt3atm1Amc/Wnt3avt
Genetic Background: involves: 129S1/Sv * C3H/HeJ * C57BL/6J * C57BR

 MP:0004714 truncated notochord "notochord morphology that terminates abruptly as if having an end or point cut off" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Wnt3atm1Amc/Wnt3atm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp5se-Ca/Bmp5+
Genetic Background: SEACGn.CB-Bmp5se-Ca

 MP:0006288 small otic capsule "reduced size of the cartilage or bony capsule surrounding the inner ear mechanism" [J:59285, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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 MP:0008031 decreased Cajal-Retzius cell number "reduced number of the distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(Otx1-cre)1Eag/0,Wnt3atm2Eag/Wnt3a+
Genetic Background: Not Specified

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Relnrl/Reln+,Wnt3atm1(cre)Eag/Wnt3a+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Relnrl/Reln+,Trp73tm1(cre)Agof/Trp73+,Wnt3atm1(cre)Eag/Wnt3a+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Wnt3avt/Wnt3avt
Genetic Background: involves: C3H/HeJ * C57BL/6J * C57BR

 MP:0008787 abnomal tailgut morphology "any structural anomaly of the extension of the hindgut of the primitive digestive tube of the embryo, caudal to the location of the anal opening" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt3avt/Wnt3avt
Genetic Background: involves: A * A/Gr * C57BR

 MP:0008934 absent choroid plexus "absence of the fringe of the tela choroidea of the brain ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Wnt3atm2Eag/Wnt3a+
Genetic Background: involves: 129S2/SvPas

 MP:0009845 abnormal neural crest cell morphology "any structural anomaly of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and disperse to many peripheral locations to form various tissues of the adult" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt3atm1Amc/Wnt3a+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt3atm1Amc/Wnt3a+
Genetic Background: involves: 129 * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Wnt3atm1Amc/Wnt3atm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Wnt3atm1Amc/Wnt3atm1Amc
Genetic Background: involves: 129S1/Sv

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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 MP:0012063 absent tail bud "missing the primordial region of the embryo that arises to form the tail of the adult" [MGI:anna]
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Allelic Composition: Wnt3atm1Amc/Wnt3atm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0012714 decreased ventral ectodermal ridge size "reduced size of the morphologically distinct group of ectodermal cells that serves as an important signaling center in the mouse tail-bud following completion of gastrulation, and contains progenitor cells that contribute to the ventral midline ectoderm of the tail" [MGI:anna]
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Allelic Composition: Wnt3avt/Wnt3avt
Genetic Background: involves: A * A/Gr * C57BR

 MP:0030121 small temporal bone squamous part "reduced size of the anterosuperior portion of the temporal bone that is thin, scale-like, and translucent and forms part of the lateral wall of the cranial vault" [MGI:anna]
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 MP:0030383 small presphenoid bone "reduced size of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [MGI:anna]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003233 Dvl3 / Q61062 / Segment polarity DVL-3 / Q92997* / dishevelled segment polarity protein 3*  / complex
 ENSMUSG00000024182 Axin1 / O15169*  / reaction / complex
 ENSMUSG00000034177 Rnf43 / Q5NCP0 / E3 ubiquitin-protein ligase RNF43 / Q68DV7* / ring finger protein 43*  / complex / reaction
 ENSMUSG00000050288 Fzd2 / Q9JIP6 / Frizzled-2 / Q14332* / frizzled class receptor 2*  / complex
 ENSMUSG00000041961 Znrf3 / Q5SSZ7 / zinc and ring finger 3 / Q9ULT6*  / reaction / complex
 ENSMUSG00000044674 Fzd1 / O70421 / Frizzled-1 / Q9UP38* / frizzled class receptor 1*  / complex
 ENSMUSG00000030201 Lrp6 / LDL receptor related protein 6 / O75581*  / complex
 ENSMUSG00000022812 Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*  / reaction / complex
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / complex
 ENSMUSG00000020218 Wif1 / Q9WUA1 / Wnt inhibitory factor 1 / Q9Y5W5*  / complex / reaction
 ENSMUSG00000027996 Sfrp2 / P97299 / secreted frizzled-related protein 2 / Q96HF1*  / reaction / complex
 ENSMUSG00000027363 Usp8 / Q80U87 / ubiquitin specific peptidase 8 / P40818*  / reaction
 ENSMUSG00000029071 Dvl1 / P51141 / Segment polarity DVL-1 / O14640* / dishevelled segment polarity protein 1*  / complex
 ENSMUSG00000049791 Fzd4 / Q61088 / Frizzled-4 / Q9ULV1* / frizzled class receptor 4*  / complex
 ENSMUSG00000031169 Porcn / Q9JJJ7 / Protein-serine O-palmitoleoyltransferase porcupine / Q9H237* / porcupine O-acyltransferase*  / reaction






 

2 s.

 
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contact: otassy@igbmc.fr