ENSMUSG00000033227


Mus musculus

Features
Gene ID: ENSMUSG00000033227
  
Biological name :Wnt6
  
Synonyms : P22727 / wingless-type MMTV integration site family, member 6 / Wnt6
  
Possible biological names infered from orthology : Q9Y6F9 / Wnt family member 6
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C4
Gene start: 74771892
Gene end: 74785322
  
Corresponding Affymetrix probe sets: 10347491 (MoGene1.0st)   1419708_at (Mouse Genome 430 2.0 Array)   1435980_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006716
NCBI entrez gene - 22420     See in Manteia.
MGI - MGI:98960
RefSeq - XM_006495889
RefSeq - NM_009526
RefSeq - XM_006495887
RefSeq - XM_006495888
RefSeq Peptide - NP_033552
swissprot - P22727
Ensembl - ENSMUSG00000033227
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnt6bENSDARG00000073935Danio rerio
 WNT6ENSGALG00000011358Gallus gallus
 WNT6ENSG00000115596Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wnt1 / P04426 / wingless-type MMTV integration site family, member 1 / P04628* / Wnt family member 1*ENSMUSG0000002299743
Wnt4 / P22724 / wingless-type MMTV integration site family, member 4 / P56705* / Wnt family member 4*ENSMUSG0000003685641
Wnt3a / P27467 / wingless-type MMTV integration site family, member 3A / P56704* / Wnt family member 3A*ENSMUSG0000000990040
Wnt5b / P22726 / wingless-type MMTV integration site family, member 5B / Q9H1J7* / Wnt family member 5B*ENSMUSG0000003017040
Wnt3 / P17553 / wingless-type MMTV integration site family, member 3 / P56703* / Wnt family member 3*ENSMUSG0000000012539
Wnt2b / O70283 / wingless-type MMTV integration site family, member 2B / Q93097* / Wnt family member 2B*ENSMUSG0000002784038
Wnt7b / P28047 / wingless-type MMTV integration site family, member 7B / P56706* / Wnt family member 7B*ENSMUSG0000002238238
Wnt7a / P24383 / wingless-type MMTV integration site family, member 7A / O00755* / Wnt family member 7A*ENSMUSG0000003009337
Wnt5a / P22725 / wingless-type MMTV integration site family, member 5A / P41221* / Wnt family member 5A*ENSMUSG0000002199437
Wnt2 / P21552 / wingless-type MMTV integration site family, member 2 / P09544* / Wnt family member 2*ENSMUSG0000001079737
Wnt16 / Q9QYS1 / wingless-type MMTV integration site family, member 16 / Q9UBV4* / Wnt family member 16*ENSMUSG0000002967135
Wnt11 / P48615 / wingless-type MMTV integration site family, member 11 / O96014* / Wnt family member 11*ENSMUSG0000001595734


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR009143  Wnt-6 protein
 IPR018161  Wnt protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IGI
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009798 axis specification IDA
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0016055 Wnt signaling pathway IDA
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0045165 cell fate commitment IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0060684 epithelial-mesenchymal cell signaling IDA
 biological_processGO:0070172 positive regulation of tooth mineralization IEA
 biological_processGO:0072079 nephron tubule formation IDA
 biological_processGO:0072080 nephron tubule development IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0009986 cell surface IDA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005109 frizzled binding IBA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0001727 abnormal embryo implantation "failure or reduced ability of the blastocyst to attach to the endometrium of the uterus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003845 abnormal decidualization "disrupted proliferation, differentiation or transformation of endometrial stromal cells into decidual cells in the maternal uterus following embryo implantation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:43609, J:48920]
Show

Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004256 abnormal maternal decidual layer morphology "anomaly in the structure of the maternal uterine-derived portion of the placenta" [PMID:11433360]
Show

Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr