ENSMUSG00000000125


Mus musculus

Features
Gene ID: ENSMUSG00000000125
  
Biological name :Wnt3
  
Synonyms : P17553 / wingless-type MMTV integration site family, member 3 / Wnt3
  
Possible biological names infered from orthology : P56703 / Wnt family member 3
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E1
Gene start: 103774150
Gene end: 103817957
  
Corresponding Affymetrix probe sets: 10381738 (MoGene1.0st)   1450763_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000127
NCBI entrez gene - 22415     See in Manteia.
MGI - MGI:98955
RefSeq - NM_009521
RefSeq Peptide - NP_033547
swissprot - A2A649
swissprot - P17553
Ensembl - ENSMUSG00000000125
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnt3ENSDARG00000038990Danio rerio
 WNT3ENSGALG00000001079Gallus gallus
 WNT3ENSG00000108379Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wnt3a / P27467 / wingless-type MMTV integration site family, member 3A / P56704* / Wnt family member 3A*ENSMUSG0000000990083
Wnt4 / P22724 / wingless-type MMTV integration site family, member 4 / P56705* / Wnt family member 4*ENSMUSG0000003685647
Wnt7b / P28047 / wingless-type MMTV integration site family, member 7B / P56706* / Wnt family member 7B*ENSMUSG0000002238244
Wnt5b / P22726 / wingless-type MMTV integration site family, member 5B / Q9H1J7* / Wnt family member 5B*ENSMUSG0000003017044
Wnt5a / P22725 / wingless-type MMTV integration site family, member 5A / P41221* / Wnt family member 5A*ENSMUSG0000002199444
Wnt2b / O70283 / wingless-type MMTV integration site family, member 2B / Q93097* / Wnt family member 2B*ENSMUSG0000002784043
Wnt1 / P04426 / wingless-type MMTV integration site family, member 1 / P04628* / Wnt family member 1*ENSMUSG0000002299743
Wnt2 / P21552 / wingless-type MMTV integration site family, member 2 / P09544* / Wnt family member 2*ENSMUSG0000001079743
Wnt7a / P24383 / wingless-type MMTV integration site family, member 7A / O00755* / Wnt family member 7A*ENSMUSG0000003009342
Wnt16 / Q9QYS1 / wingless-type MMTV integration site family, member 16 / Q9UBV4* / Wnt family member 16*ENSMUSG0000002967141
Wnt6 / P22727 / wingless-type MMTV integration site family, member 6 / Q9Y6F9* / Wnt family member 6*ENSMUSG0000003322740
Wnt11 / P48615 / wingless-type MMTV integration site family, member 11 / O96014* / Wnt family member 11*ENSMUSG0000001595735


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR009141  Wnt-3 protein
 IPR018161  Wnt protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0001707 mesoderm formation IMP
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007276 gamete generation IGI
 biological_processGO:0007411 axon guidance IDA
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0009948 anterior/posterior axis specification IMP
 biological_processGO:0009950 dorsal/ventral axis specification IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IDA
 biological_processGO:0035115 embryonic forelimb morphogenesis IMP
 biological_processGO:0035116 embryonic hindlimb morphogenesis IMP
 biological_processGO:0044338 canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation ISO
 biological_processGO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation ISO
 biological_processGO:0045165 cell fate commitment IBA
 biological_processGO:0048646 anatomical structure formation involved in morphogenesis IMP
 biological_processGO:0048697 positive regulation of collateral sprouting in absence of injury IDA
 biological_processGO:0048843 negative regulation of axon extension involved in axon guidance IDA
 biological_processGO:0050767 regulation of neurogenesis IEA
 biological_processGO:0060064 Spemann organizer formation at the anterior end of the primitive streak IMP
 biological_processGO:0060070 canonical Wnt signaling pathway ISO
 biological_processGO:0060173 limb development IMP
 biological_processGO:0060174 limb bud formation ISO
 biological_processGO:0060323 head morphogenesis IGI
 biological_processGO:0061180 mammary gland epithelium development IEA
 biological_processGO:0072089 stem cell proliferation ISO
 biological_processGO:1904954 canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation ISO
 biological_processGO:1905474 canonical Wnt signaling pathway involved in stem cell proliferation ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005109 frizzled binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0048018 receptor ligand activity IEA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000549 absent limbs "missing extremities" [J:51966, J:50768]
Show

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
Show

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Cx3cr1tm1Ifc/Cx3cr1tm1Ifc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Wnt3tm1Amc/Wnt3tm2Amc,Tg(Rarb-cre)1Mrc/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
Show

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Cx3cr1tm1Ifc/Cx3cr1tm1Ifc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000557 absent hindlimb "missing the entire posterior extremities" [MGI:tc, J:54637]
Show

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Cx3cr1tm1Ifc/Cx3cr1tm1Ifc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Cx3cr1tm1Ifc/Cx3cr1tm1Ifc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Lrp6Gw/Lrp6+
Genetic Background: involves: 101/H * BALB/c * C3H/HeH

 MP:0001674 abnormal triploblastic development "abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

 MP:0001676 abnormal apical ectodermal ridge "malformation of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
Show

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Cx3cr1tm1Ifc/Cx3cr1tm1Ifc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Wnt3tm1Amc/Wnt3tm2Amc,Tg(Rarb-cre)1Mrc/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0001679 thin apical ectodermal ridge "decrease in the thickness of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
Show

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Cx3cr1tm1Ifc/Cx3cr1tm1Ifc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
Show

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

 MP:0001693 failure of primitive streak formation "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
Show

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
Show

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

 MP:0001710 absent amniotic folds "failure of amnion to form involutions" [J:40594]
Show

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

 MP:0001724 abnormal extraembryonic endoderm formation "malformation of the endoderm of the extraembryonic tissue that appears prior to gastrulation and performs critical functions during embryogenesis including nutrient uptake and transport from the mother to the embryo" [J:62628]
Show

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eomestm1Rob/Eomes+,Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0003087 absent allantois "missing fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

 MP:0003895 increased ectoderm apoptosis "increase in the number of ectoderm cells undergoing programmed cell death during development" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Cx3cr1tm1Ifc/Cx3cr1tm1Ifc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
Show

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

 MP:0005030 absent amnion "missing innermost of the extraembryonic membranes" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

 MP:0006207 embryonic lethality during organogenesis "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008392 decreased primordial germ cell number "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4+,Ctdnep1tm1Ryn/Ctdnep1tm1Ryn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA

 MP:0009331 absent primitive node "absence of the regional thickening of cells at the rostral tip of the vertebrate primitive streak through which gastrulating cells migrate anteriorally to form tissues in the future head and neck; this region organizes the formation of the three embryonic layers and establishes the longitudinal axis and the polarity of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

 MP:0009593 absent chorion "absence of the outermost extraembryonic membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

 MP:0011206 absent visceral yolk sac "absence of the extraembryonic tissue membrane, formed from the visceral endoderm and the extraembryonic mesoderm, which is located ventral to the embryonic disc and is connected to the presumptive midgut of the embryo" [ISBN10:9780123364258, PMID:21123814]
Show

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr