ENSMUSG00000036856


Mus musculus

Features
Gene ID: ENSMUSG00000036856
  
Biological name :Wnt4
  
Synonyms : P22724 / wingless-type MMTV integration site family, member 4 / Wnt4
  
Possible biological names infered from orthology : P56705 / Wnt family member 4
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D3
Gene start: 137277489
Gene end: 137299726
  
Corresponding Affymetrix probe sets: 10509267 (MoGene1.0st)   10509273 (MoGene1.0st)   1441687_at (Mouse Genome 430 2.0 Array)   1450782_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036580
NCBI entrez gene - 22417     See in Manteia.
MGI - MGI:98957
RefSeq - NM_009523
RefSeq Peptide - NP_033549
swissprot - P22724
swissprot - Q3ZB23
Ensembl - ENSMUSG00000036856
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnt4aENSDARG00000071208Danio rerio
 WNT4ENSGALG00000041708Gallus gallus
 WNT4ENSG00000162552Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wnt3 / P17553 / wingless-type MMTV integration site family, member 3 / P56703* / Wnt family member 3*ENSMUSG0000000012548
Wnt5a / P22725 / wingless-type MMTV integration site family, member 5A / P41221* / Wnt family member 5A*ENSMUSG0000002199447
Wnt5b / P22726 / wingless-type MMTV integration site family, member 5B / Q9H1J7* / Wnt family member 5B*ENSMUSG0000003017046
Wnt2b / O70283 / wingless-type MMTV integration site family, member 2B / Q93097* / Wnt family member 2B*ENSMUSG0000002784046
Wnt3a / P27467 / wingless-type MMTV integration site family, member 3A / P56704* / Wnt family member 3A*ENSMUSG0000000990046
Wnt2 / P21552 / wingless-type MMTV integration site family, member 2 / P09544* / Wnt family member 2*ENSMUSG0000001079745
Wnt7a / P24383 / wingless-type MMTV integration site family, member 7A / O00755* / Wnt family member 7A*ENSMUSG0000003009345
Wnt7b / P28047 / wingless-type MMTV integration site family, member 7B / P56706* / Wnt family member 7B*ENSMUSG0000002238245
Wnt1 / P04426 / wingless-type MMTV integration site family, member 1 / P04628* / Wnt family member 1*ENSMUSG0000002299744
Wnt6 / P22727 / wingless-type MMTV integration site family, member 6 / Q9Y6F9* / Wnt family member 6*ENSMUSG0000003322743
Wnt16 / Q9QYS1 / wingless-type MMTV integration site family, member 16 / Q9UBV4* / Wnt family member 16*ENSMUSG0000002967141
Wnt11 / P48615 / wingless-type MMTV integration site family, member 11 / O96014* / Wnt family member 11*ENSMUSG0000001595737


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR009142  Wnt-4 protein
 IPR018161  Wnt protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001656 metanephros development TAS
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IMP
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001823 mesonephros development IMP
 biological_processGO:0001837 epithelial to mesenchymal transition IEA
 biological_processGO:0001838 embryonic epithelial tube formation IDA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0006702 androgen biosynthetic process IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007276 gamete generation IGI
 biological_processGO:0007548 sex differentiation IMP
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0008585 female gonad development IMP
 biological_processGO:0009267 cellular response to starvation IEP
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010894 negative regulation of steroid biosynthetic process IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0022407 regulation of cell-cell adhesion IMP
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0030237 female sex determination ISS
 biological_processGO:0030325 adrenal gland development IEA
 biological_processGO:0030336 negative regulation of cell migration IGI
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0032349 positive regulation of aldosterone biosynthetic process IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IEA
 biological_processGO:0033077 T cell differentiation in thymus IDA
 biological_processGO:0033080 immature T cell proliferation in thymus IMP
 biological_processGO:0035239 tube morphogenesis IMP
 biological_processGO:0035567 non-canonical Wnt signaling pathway IDA
 biological_processGO:0038030 non-canonical Wnt signaling pathway via MAPK cascade IEA
 biological_processGO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway IGI
 biological_processGO:0042445 hormone metabolic process IMP
 biological_processGO:0043547 positive regulation of GTPase activity IGI
 biological_processGO:0045165 cell fate commitment IMP
 biological_processGO:0045596 negative regulation of cell differentiation IMP
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045836 positive regulation of meiotic nuclear division IGI
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048599 oocyte development IMP
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IGI
 biological_processGO:0048856 anatomical structure development IGI
 biological_processGO:0051145 smooth muscle cell differentiation IMP
 biological_processGO:0051496 positive regulation of stress fiber assembly IGI
 biological_processGO:0051894 positive regulation of focal adhesion assembly IGI
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060126 somatotropin secreting cell differentiation IMP
 biological_processGO:0060129 thyroid-stimulating hormone-secreting cell differentiation IMP
 biological_processGO:0060231 mesenchymal to epithelial transition IMP
 biological_processGO:0060748 tertiary branching involved in mammary gland duct morphogenesis IMP
 biological_processGO:0060993 kidney morphogenesis IGI
 biological_processGO:0061045 negative regulation of wound healing IGI
 biological_processGO:0061180 mammary gland epithelium development IEA
 biological_processGO:0061184 positive regulation of dermatome development ISS
 biological_processGO:0061205 paramesonephric duct development IEA
 biological_processGO:0061369 negative regulation of testicular blood vessel morphogenesis IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0072006 nephron development IMP
 biological_processGO:0072033 renal vesicle formation IMP
 biological_processGO:0072034 renal vesicle induction IDA
 biological_processGO:0072162 metanephric mesenchymal cell differentiation NAS
 biological_processGO:0072164 mesonephric tubule development IGI
 biological_processGO:0072174 metanephric tubule formation IMP
 biological_processGO:0072210 metanephric nephron development IMP
 biological_processGO:0072273 metanephric nephron morphogenesis IMP
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IDA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:2000019 negative regulation of male gonad development IEA
 biological_processGO:2000066 positive regulation of cortisol biosynthetic process IEA
 biological_processGO:2000225 negative regulation of testosterone biosynthetic process IMP
 biological_processGO:2001234 negative regulation of apoptotic signaling pathway IGI
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0009986 cell surface IDA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005109 frizzled binding IPI
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking
PCP/CE pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Gsk3btm1Grc/Gsk3b+
Genetic Background: involves: 129S6/SvEvTac

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Wnt4tm2(EGFP/cre)Svo/Wnt4tm1Svo
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Timp3tm1Osya/Timp3tm1Osya
Genetic Background: B6.129P2-Timp3tm1Osya

Allelic Composition: Wnt4tm2(EGFP/cre)Svo/Wnt4tm1Svo
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Wnt4tm1.2Boer/Wnt4tm1.2Boer
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Wnt4tm1.1Boer/Wnt4tm1.2Boer
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

 MP:0000528 delayed kidney development "late onset of the induction and/or differentiation of the kidney" [J:18048]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd,Wnt4tm1Amc/Wnt4tm1Amc
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tg(ACTFLPe)9205Dym/0,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Wnt4tm1Amc/Wnt4+,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5a+,Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tg(ACTFLPe)9205Dym/0,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5a+,Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001511 disheveled coat "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Wnt4tm1.1Boer/Wnt4tm1.2Boer
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Wnt4tm1.1Boer/Wnt4tm1.2Boer
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

 MP:0001931 abnormal oogenesis "atypical formation or failure to form the female germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Wnt4tm1Amc/Wnt4tm3(EGFP/cre)Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Wnt4tm1Amc/Wnt4tm3(EGFP/cre)Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Wnt4tm1.1Boer/Wnt4tm1.2Boer
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

 MP:0001939 secondary sex reversal "secondary sexual phenotype is not consistent with the chromosomal sex, i.e., internal and/or external genitalia are inconsistent with chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Wnt4tm1.1Boer/Wnt4tm1.2Boer
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tg(ACTFLPe)9205Dym/0,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Wnt4tm1Amc/Wnt4+,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5a+,Wnt5btm1Tmj/Wnt5btm1Tmj
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gsk3btm1Grc/Gsk3b+
Genetic Background: involves: 129S6/SvEvTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Timp3tm1Osya/Timp3tm1Osya
Genetic Background: B6.129P2-Timp3tm1Osya

Allelic Composition: Wnt4tm1.1Boer/Wnt4tm1.1Boer
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002212 abnormal secondary sex determination "gonadal development may or may not be normal, and the phenotype of the animal outside the gonad does not match chromosomal sex or is ambiguous" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Wnt4tm1.1Boer/Wnt4tm1.2Boer
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gsk3btm1Grc/Gsk3b+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Hnf1btm1Ics/Hnf1b+,Wnt4tm2(EGFP/cre)Svo/Wnt4+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002909 abnormal adrenal gland physiology "altered ability of the surparenal gland to produce and secrete hormones " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Tenm4l7Rn3-6R/Tenm4l7Rn3-6R
Genetic Background: involves: BALB/cRl * C3H/Rl * C57BL/10Rl

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt4tm2(EGFP/cre)Svo/Wnt4tm1Svo
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Tcf21tm2.1Seq/Tcf21tm1Jrt,Wnt4tm2(EGFP/cre)Svo/Wnt4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002995 primary sex reversal "gonad type is not consistent with chromosomal sex" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt4tm2(EGFP/cre)Svo/Wnt4tm1Svo
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003582 abnormal ovary development "abnormal morphogenesis of the female reproductive gland containing the germ cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Wnt4tm2(EGFP/cre)Svo/Wnt4tm1Svo
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Wnt4tm1.1Boer/Wnt4tm1.2Boer
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0003936 abnormal reproductive system development "developmental anomaly of any of the organs involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt4tm1.2Boer/Wnt4tm1.2Boer
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0004163 abnormal adenophysis morphology "any malformation or absence of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tenm4l7Rn3-6R/Tenm4l7Rn3-6R
Genetic Background: involves: BALB/cRl * C3H/Rl * C57BL/10Rl

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Wnt4tm1.1Boer/Wnt4tm1.2Boer
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

 MP:0004755 abnormal loop of Henle "any structural anomaly of the section of the renal tubule in the kidney medulla with a hairpin bend; consists of a descending limb and an ascending limb, and is situated between the proximal convoluted tubule to the distal convoluted tubule; it functions to reabsorb water and ions from the urine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gsk3btm1Grc/Gsk3b+
Genetic Background: involves: 129S6/SvEvTac

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gsk3btm1Grc/Gsk3b+
Genetic Background: involves: 129S6/SvEvTac

 MP:0004856 decreased ovary weight "reduction in the average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Wnt4tm1.1Boer/Wnt4tm1.2Boer
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf21tm2.1Seq/Tcf21tm1Jrt,Tg(Nphs2-cre)1Seq/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005326 abnormal podocytes "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]
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Allelic Composition: Tcf21tm2.1Seq/Tcf21tm1Jrt,Wnt4tm2(EGFP/cre)Svo/Wnt4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Wnt4tm1Amc/Wnt4tm3(EGFP/cre)Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0006361 abnormal female germ cell morphology "any structural anomaly female germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0006425 absent Mullerian ducts "absence of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [J:40605, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0008329 decreased somatotroph cell number "reduced number of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [CL:0000295, MESH:A06.407.747.608.937]
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Allelic Composition: Tenm4l7Rn3-6R/Tenm4l7Rn3-6R
Genetic Background: involves: BALB/cRl * C3H/Rl * C57BL/10Rl

 MP:0008335 decreased gonadotroph cell number "reduced number of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)" [MESH:A06.407.747.608.750]
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Allelic Composition: Tenm4l7Rn3-6R/Tenm4l7Rn3-6R
Genetic Background: involves: BALB/cRl * C3H/Rl * C57BL/10Rl

 MP:0008338 decreased thyrotroph cell number "reduced number of an anterior pituitary cell that produces thyroid-stimulating hormone" [MESH:A06.407.747.608.968]
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Allelic Composition: Tenm4l7Rn3-6R/Tenm4l7Rn3-6R
Genetic Background: involves: BALB/cRl * C3H/Rl * C57BL/10Rl

 MP:0009093 oocyte degeneration "a retrogressive impairment of function or destruction of the female germ cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0010984 abnormal metanephric mesenchyme morphology "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing metanephros; interactions between the ureteric bud and the metanephric mesenchyme leads to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:19828308]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0010985 abnormal kidney mesenchyme morphology "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing kidney" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt4tm2(EGFP/cre)Svo/Wnt4tm1Svo
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010987 abnormal nephrogenic mesenchyme morphogenesis "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing nephron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Wnt4tm1.2Boer/Wnt4tm1.2Boer
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Hnf1btm1Ics/Hnf1btm1Sce,Wnt4tm2(EGFP/cre)Svo/Wnt4+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Wnt4tm1.2Bhr/Wnt4tm1.2Bhr
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tg(ACTFLPe)9205Dym/0,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

 MP:0011364 abnormal metanephros morphology "any structural anomaly of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord; the metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine" [GO:0001656]
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Allelic Composition: Hnf1btm1Ics/Hnf1btm1Sce,Wnt4tm2(EGFP/cre)Svo/Wnt4+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011365 small metanephros "reduced size of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord" [MGI:anna]
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0011682 renal glomerulus cysts "abnormal membranous sacs in any portion of the renal glomerulus" [MGI:csmith]
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Allelic Composition: Hnf1btm1Ics/Hnf1btm1Sce,Wnt4tm2(EGFP/cre)Svo/Wnt4+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hnf1btm1Ics/Hnf1b+,Wnt4tm2(EGFP/cre)Svo/Wnt4+
Genetic Background: involves: 129P2/OlaHsd

 MP:0013312 absent ovary capsule "missing the tough, fibrous capsule surrounding each ovary" [MGI:Anna]
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Allelic Composition: Wnt4tm2(EGFP/cre)Svo/Wnt4tm1Svo
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020218 Wif1 / Q9WUA1 / Wnt inhibitory factor 1 / Q9Y5W5*  / complex / reaction






 

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