ENSMUSG00000022997


Mus musculus

Features
Gene ID: ENSMUSG00000022997
  
Biological name :Wnt1
  
Synonyms : P04426 / wingless-type MMTV integration site family, member 1 / Wnt1
  
Possible biological names infered from orthology : P04628 / Wnt family member 1
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F1
Gene start: 98789857
Gene end: 98793837
  
Corresponding Affymetrix probe sets: 10426637 (MoGene1.0st)   1425377_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023734
NCBI entrez gene - 22408     See in Manteia.
MGI - MGI:98953
RefSeq - NM_021279
RefSeq Peptide - NP_067254
swissprot - P04426
swissprot - Q3UR96
Ensembl - ENSMUSG00000022997
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnt1ENSDARG00000055554Danio rerio
 WNT1ENSG00000125084Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wnt6 / P22727 / wingless-type MMTV integration site family, member 6 / Q9Y6F9* / Wnt family member 6*ENSMUSG0000003322743
Wnt4 / P22724 / wingless-type MMTV integration site family, member 4 / P56705* / Wnt family member 4*ENSMUSG0000003685642
Wnt3 / P17553 / wingless-type MMTV integration site family, member 3 / P56703* / Wnt family member 3*ENSMUSG0000000012541
Wnt3a / P27467 / wingless-type MMTV integration site family, member 3A / P56704* / Wnt family member 3A*ENSMUSG0000000990041
Wnt2b / O70283 / wingless-type MMTV integration site family, member 2B / Q93097* / Wnt family member 2B*ENSMUSG0000002784040
Wnt2 / P21552 / wingless-type MMTV integration site family, member 2 / P09544* / Wnt family member 2*ENSMUSG0000001079739
Wnt7a / P24383 / wingless-type MMTV integration site family, member 7A / O00755* / Wnt family member 7A*ENSMUSG0000003009336
Wnt7b / P28047 / wingless-type MMTV integration site family, member 7B / P56706* / Wnt family member 7B*ENSMUSG0000002238236
Wnt5a / P22725 / wingless-type MMTV integration site family, member 5A / P41221* / Wnt family member 5A*ENSMUSG0000002199436
Wnt16 / Q9QYS1 / wingless-type MMTV integration site family, member 16 / Q9UBV4* / Wnt family member 16*ENSMUSG0000002967136
Wnt5b / P22726 / wingless-type MMTV integration site family, member 5B / Q9H1J7* / Wnt family member 5B*ENSMUSG0000003017036
Wnt11 / P48615 / wingless-type MMTV integration site family, member 11 / O96014* / Wnt family member 11*ENSMUSG0000001595732


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR009139  Wnt-1 protein
 IPR018161  Wnt protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000578 embryonic axis specification IMP
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IGI
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007520 myoblast fusion IGI
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010592 positive regulation of lamellipodium assembly IEA
 biological_processGO:0010812 negative regulation of cell-substrate adhesion IEA
 biological_processGO:0014902 myotube differentiation IGI
 biological_processGO:0016055 Wnt signaling pathway ISO
 biological_processGO:0021527 spinal cord association neuron differentiation IGI
 biological_processGO:0021536 diencephalon development IGI
 biological_processGO:0021549 cerebellum development IMP
 biological_processGO:0021551 central nervous system morphogenesis IMP
 biological_processGO:0021588 cerebellum formation IMP
 biological_processGO:0021797 forebrain anterior/posterior pattern specification IGI
 biological_processGO:0022004 midbrain-hindbrain boundary maturation during brain development IMP
 biological_processGO:0022008 neurogenesis IDA
 biological_processGO:0022037 metencephalon development IMP
 biological_processGO:0022408 negative regulation of cell-cell adhesion IEA
 biological_processGO:0030509 BMP signaling pathway ISO
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 biological_processGO:0030579 ubiquitin-dependent SMAD protein catabolic process IDA
 biological_processGO:0030901 midbrain development IDA
 biological_processGO:0030917 midbrain-hindbrain boundary development IMP
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0033077 T cell differentiation in thymus IDA
 biological_processGO:0033278 cell proliferation in midbrain IDA
 biological_processGO:0036520 astrocyte-dopaminergic neuron signaling IMP
 biological_processGO:0042472 inner ear morphogenesis IGI
 biological_processGO:0042770 signal transduction in response to DNA damage IEA
 biological_processGO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway IEA
 biological_processGO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process IEA
 biological_processGO:0045596 negative regulation of cell differentiation IMP
 biological_processGO:0045599 negative regulation of fat cell differentiation IDA
 biological_processGO:0045747 positive regulation of Notch signaling pathway IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II NAS
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0048663 neuron fate commitment IMP
 biological_processGO:0048664 neuron fate determination IMP
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0060061 Spemann organizer formation IMP
 biological_processGO:0060070 canonical Wnt signaling pathway TAS
 biological_processGO:0060348 bone development IEA
 biological_processGO:0061184 positive regulation of dermatome development IEA
 biological_processGO:0070365 hepatocyte differentiation IEA
 biological_processGO:0071375 cellular response to peptide hormone stimulus IEA
 biological_processGO:0071425 hematopoietic stem cell proliferation IDA
 biological_processGO:0071542 dopaminergic neuron differentiation IMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IDA
 biological_processGO:0090344 negative regulation of cell aging IEA
 biological_processGO:1903204 negative regulation of oxidative stress-induced neuron death IMP
 biological_processGO:1904948 midbrain dopaminergic neuron differentiation IMP
 biological_processGO:1904954 canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation IDA
 biological_processGO:1990403 embryonic brain development IDA
 biological_processGO:2000059 negative regulation of ubiquitin-dependent protein catabolic process IDA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:1990909 Wnt signalosome IC
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005109 frizzled binding IBA
 molecular_functionGO:0005125 cytokine activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0048018 receptor ligand activity IDA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking
PCP/CE pathway
Disassembly of the destruction complex and recruitment of AXIN to the membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000109 abnormal parietal bone morphology "malformed curved bone forming part of the vault of the cranium" [J:17489]
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Allelic Composition: Zic2Ku/Zic2Ku
Genetic Background: C3.CAnNCrl-Zic2Ku

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Zic2Ku/Zic2Ku
Genetic Background: C3.CAnNCrl-Zic2Ku

Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd,Wnt4tm1Amc/Wnt4tm1Amc
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

 MP:0000737 abnormal myotome development "malformation of or absence of the part of the somite that develops into the musculature" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29279]
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 MP:0000776 abnormal inferior colliculus "dysmorphology or disorganization of the paired inferior eminence of the mesencephalic tectum that is involved in preliminary visual processing, and control of eye movements" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Zic2Ku/Zic2Ku
Genetic Background: C3.CAnNCrl-Zic2Ku

 MP:0000798 abnormal frontal lobe morphology "malformation or absence of the anterior part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Wnt1tm1Mrc/Wnt1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000841 abnormal hindbrain morphology "malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6N

 MP:0000847 abnormal metencephalon morphology "any malformation or absence of the anterior part of the rhombencephalon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Wnt1tm1Mrc/Wnt1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000850 absent cerebellum "missing the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Wnt1tm1Mrc/Wnt1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

 MP:0000867 abnormal anterior vermis "malformation in the anterior portion of the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Fgf15tm1Sms/Fgf15tm1Sms,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6N

Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Wnt1-cre/ERT)1Alj/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * Swiss Webster

Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0000933 abnormal rhombomere morphology "malformation of the transverse segments in the hindbrain region of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6N

 MP:0000964 small dorsal root ganglia "reduced size of the dorsal root ganglia" [J:17123]
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 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Fgf15tm1Sms/Fgf15tm1Sms,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf15tm1Sms/Fgf15tm1Sms,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

 MP:0001704 abnormal dorsal-ventral axis patterning "anomaly in the development or formation of the axis that runs from the front to the back surface of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Fgf15tm1Sms/Fgf15tm1Sms,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6N

 MP:0002260 abnormal thyroid cartilage morphology "any structural anomaly of the largest of the laryngeal cartilages " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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 MP:0003312 abnormal locomotor coordination "reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

 MP:0003424 premature neuronal precursor differentiation "earlier than normal transformation of neuronal precursor cells into neurons" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
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Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0003864 abnormal midbrain development "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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 MP:0004096 abnormal midbrain-hindbrain boundary development "anomaly in the formation of the midbrain-hindbrain domain, comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; an organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004097 abnormal cerebellar cortex morphology "any structural anomaly of the thin mantle of gray matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

 MP:0004143 hypertonia "increased muscle tone" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

 MP:0004203 abnormal cranial flexure "any structural abnormality or absence of the sharp, ventrally concave bend in the developing midbrain of the embryo" [J:10730, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004204 absent stapes "absence of the smallest and innermost of the three auditory ossicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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 MP:0004205 absent hyoid bone "absence of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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 MP:0004206 abnormal dermomyotome development "any structural anomaly of the portion of the embryonic somite that remains after migration of the sclerotomic tissue" [J:50279, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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 MP:0004459 small alisphenoid bone "reduced size of either of the broad curved wing like expanses on each side of the sphenoid bone in adults; may exist independently in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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 MP:0004462 small basisphenoid bone "reduced size of part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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 MP:0004814 reduced linear vestibular evoked potential "reduction of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grid2ho-4J/Grid2ho-4J
Genetic Background: DBA/2J-Grid2ho-4J/J

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6N

 MP:0006011 abnormal endolymphatic duct morphology "any structural alteration in the small membranous canal, connecting with both saccule and utricle of the membranous labyrinth, passing through the aqueduct of vestibule, and terminating in the endolymphatic sac." [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gsk3btm1Grc/Gsk3b+
Genetic Background: involves: 129S6/SvEvTac

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
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Allelic Composition: Flnatm1.1Caw/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0006288 small otic capsule "reduced size of the cartilage or bony capsule surrounding the inner ear mechanism" [J:59285, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

 MP:0008913 listing "momentary, slow motions of the whole body from side to side sometimes followed by a sudden drop from an erect position" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6N

Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0009845 abnormal neural crest cell morphology "any structural anomaly of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and disperse to many peripheral locations to form various tissues of the adult" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Wnt1tm1Mrc/Wnt1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Flnatm1.1Caw/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Wnt1tm1Mrc/Wnt1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0012087 absent midbrain "absence of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna]
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Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Wnt1tm1Amc/Wnt1tm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0012089 decreased midbrain size "size reduction or truncation of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith]
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Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0012133 absent midbrain-hindbrain boundary "absence of the midbrain-hindbrain domain of the embryonic brain that is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; normally, an organizing center located at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [MGI:anna]
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Allelic Composition: Zfp36tm1.2Xen/Zfp36tm1.2Xen
Genetic Background: C57BL/6-Zfp36tm1.2Xen

 MP:0012516 absent metencephalon "absence of the anterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain normally composed of the cerebellum and the pons Varolii" [MGI:anna]
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Allelic Composition: Wnt1tm1Amc/Wnt1tm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0012785 decreased rhombomere 1 size "reduced size of the first transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order with the first rhombomere arising next to the midbrain-hindbrain boundary, or isthmus" [MGI:anna]
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Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0030121 small temporal bone squamous part "reduced size of the anterosuperior portion of the temporal bone that is thin, scale-like, and translucent and forms part of the lateral wall of the cranial vault" [MGI:anna]
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 MP:0030383 small presphenoid bone "reduced size of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [MGI:anna]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003233 Dvl3 / Q61062 / Segment polarity DVL-3 / Q92997* / dishevelled segment polarity protein 3*  / complex
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / complex / reaction
 ENSMUSG00000044674 Fzd1 / O70421 / Frizzled-1 / Q9UP38* / frizzled class receptor 1*  / complex
 ENSMUSG00000022812 Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*  / complex / reaction
 ENSMUSG00000030201 Lrp6 / LDL receptor related protein 6 / O75581*  / complex
 ENSMUSG00000024182 Axin1 / O15169*  / complex / reaction
 ENSMUSG00000041075 Fzd7 / Q61090 / Frizzled-7 / O75084* / frizzled class receptor 7*  / complex
 ENSMUSG00000050288 Fzd2 / Q9JIP6 / Frizzled-2 / Q14332* / frizzled class receptor 2*  / complex
 ENSMUSG00000029071 Dvl1 / P51141 / Segment polarity DVL-1 / O14640* / dishevelled segment polarity protein 1*  / complex






 

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