ENSDARG00000055554


Danio rerio

Features
Gene ID: ENSDARG00000055554
  
Biological name :wnt1
  
Synonyms : P24257 / wingless-type MMTV integration site family, member 1 / wnt1
  
Possible biological names infered from orthology : P04426 / P04628 / Wnt family member 1
  
Species: Danio rerio
  
Chr. number: 23
Strand: 1
Band:
Gene start: 27652906
Gene end: 27658054
  
Corresponding Affymetrix probe sets: Dr.15701.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000072397
NCBI entrez gene - 30128     See in Manteia.
RefSeq - NM_001201398
RefSeq Peptide - NP_001188327
swissprot - B3DI55
swissprot - P24257
ZFIN ID - ZDB-GENE-980526-526
Ensembl - ENSDARG00000055554
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 WNT1ENSG00000125084Homo sapiens
 Wnt1ENSMUSG00000022997Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
wnt3a / wingless-type MMTV integration site family, member 3A / P56704* / Wnt family member 3A*ENSDARG0000005882242
wnt3 / wingless-type MMTV integration site family, member 3 / P17553* / P56703* / Wnt family member 3*ENSDARG0000003899042
wnt6b / wingless-type MMTV integration site family, member 6b / WNT6* / Q9Y6F9* / P22727* / Wnt family member 6* / wingless-type MMTV integration site family, member 6*ENSDARG0000007393541
wnt4a / P47793 / wingless-type MMTV integration site family, member 4a / WNT4* / P56705* / P22724* / Wnt family member 4* / wingless-type MMTV integration site family, member 4*ENSDARG0000007120841
wnt4b / wingless-type MMTV integration site family, member 4bENSDARG0000004015940
wnt5b / Q92050 / wingless-type MMTV integration site family, member 5b / Q9H1J7* / P22726* / Wnt family member 5B*ENSDARG0000010246439
wnt2ba / wingless-type MMTV integration site family, member 2Ba / WNT2B* / Q93097* / Wnt family member 2B*ENSDARG0000000505039
wnt5a / wingless-type MMTV integration site family, member 5a / P41221* / Wnt family member 5A*ENSDARG0000010497339
wnt7bb / wingless-type MMTV integration site family, member 7Bb / WNT7B* / P56706* / P28047* / Wnt family member 7B* / wingless-type MMTV integration site family, member 7B*ENSDARG0000007110738
wnt2 / Q92048 / wingless-type MMTV integration site family member 2 / P21552* / P09544* / Wnt family member 2*ENSDARG0000004111738
wnt2bb / wingless-type MMTV integration site family, member 2Bb / WNT2B* / Q93097* / O70283* / Wnt family member 2B* / wingless-type MMTV integration site family, member 2B*ENSDARG0000003223438
wnt7ba / wingless-type MMTV integration site family, member 7Ba / WNT7B* / P56706* / P28047* / Wnt family member 7B* / wingless-type MMTV integration site family, member 7B*ENSDARG0000002285837
wnt16 / wingless-type MMTV integration site family, member 16 / Q9QYS1* / Q9UBV4* / Wnt family member 16*ENSDARG0000009497337
wnt6a / wingless-type MMTV integration site family, member 6aENSDARG0000003828336
wnt7aa / wingless-type MMTV integration site family, member 7Aa / WNT7A* / P24383* / O00755* / Wnt family member 7A* / wingless-type MMTV integration site family, member 7A*ENSDARG0000004482735
wnt7ab / wingless-type MMTV integration site family, member 7Ab / WNT7A* / O00755* / Wnt family member 7A*ENSDARG0000000248335
wnt11r / wingless-type MMTV integration site family, member 11, related / WNT11* / P48615* / O96014* / Wnt family member 11* / wingless-type MMTV integration site family, member 11*ENSDARG0000001479631
wnt11 / wingless-type MMTV integration site family, member 11ENSDARG0000000425630


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR009139  Wnt-1 protein
 IPR018161  Wnt protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0016055 Wnt signaling pathway IBA
 biological_processGO:0021587 cerebellum morphogenesis IMP
 biological_processGO:0021592 fourth ventricle development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0030902 hindbrain development IMP
 biological_processGO:0030917 midbrain-hindbrain boundary development IGI
 biological_processGO:0035284 brain segmentation IMP
 biological_processGO:0045165 cell fate commitment IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005109 frizzled binding IBA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking
PCP/CE pathway
Disassembly of the destruction complex and recruitment of AXIN to the membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000029 hindbrain hindbrain decreased width , abnormal
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 ZFA:0000110 fourth ventricle fourth ventricle structure , abnormal
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 ZFA:0000310 cranial nerve VI cranial nerve VI hypoplastic , abnormal
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 ZFA:0000453 cranial nerve X cranial nerve X hypoplastic , abnormal
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 ZFA:0000664 cranial nerve VII cranial nerve VII hypoplastic , abnormal
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 ZFA:0000668 cranial nerve IX cranial nerve IX hypoplastic , abnormal
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 ZFA:0009052 motor neuron motor neuron decreased amount , abnormal
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 ZFA:0009073 glial cell glial cell mislocalised , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000027589 fzd7b / frizzled class receptor 7b / FZD7* / O75084* / Q61090* / Frizzled-7 * / frizzled class receptor 7*  / complex
 ENSDARG00000017803 gsk3b / glycogen synthase kinase 3 beta / P49841* / Q9WV60*  / complex / reaction
 ENSDARG00000052468 si:dkeyp-80c12.7 / GSK3B (1 of many) / GSK3B* / P49841* / Q9WV60* / glycogen synthase kinase 3 beta*  / reaction / complex
 ENSDARG00000106062 fzd1 / frizzled class receptor 1 / Q9UP38*  / complex
 ENSDARG00000102964 axin1 / O15169*  / complex / reaction
 ENSDARG00000010515 dvl1a / dishevelled segment polarity protein 1a / DVL1* / P51141* / O14640* / Segment polarity DVL-1 * / dishevelled segment polarity protein 1*  / complex
 ENSDARG00000055552 dvl1b / dishevelled segment polarity protein 1b / DVL1* / P51141* / O14640* / Segment polarity DVL-1 * / dishevelled segment polarity protein 1*  / complex






 

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