ENSDARG00000052468


Danio rerio

Features
Gene ID: ENSDARG00000052468
  
Biological name :GSK3B (1 of many)
  
Synonyms : GSK3B (1 of many) / si:dkeyp-80c12.7
  
Possible biological names infered from orthology : glycogen synthase kinase 3 beta / GSK3B / P49841 / Q9WV60
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 49370549
Gene end: 49409549
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000068806
NCBI entrez gene - 557882     See in Manteia.
RefSeq - NM_001145688
RefSeq Peptide - NP_001139160
swissprot - B8JIQ1
ZFIN ID - ZDB-GENE-090312-2
Ensembl - ENSDARG00000052468
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GSK3BENSGALG00000014977Gallus gallus
 GSK3BENSG00000082701Homo sapiens
 Gsk3bENSMUSG00000022812Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gsk3b / glycogen synthase kinase 3 beta / P49841* / Q9WV60*ENSDARG0000001780391
gsk3ab / glycogen synthase kinase 3 alpha b / GSK3A* / Q2NL51* / P49840* / AC006486.1* / glycogen synthase kinase 3 alpha*ENSDARG0000001568177
gsk3aa / glycogen synthase kinase 3 alpha a / GSK3A* / Q2NL51* / P49840* / AC006486.1* / glycogen synthase kinase 3 alpha*ENSDARG0000002950177


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033573  Glycogen synthase kinase-3 beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Regulation of HSF1-mediated heat shock response
CRMPs in Sema3A signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000010515 dvl1a / dishevelled segment polarity protein 1a / DVL1* / P51141* / O14640* / Segment polarity DVL-1 * / dishevelled segment polarity protein 1*  / reaction / complex
 ENSDARG00000055554 wnt1 / P24257 / wingless-type MMTV integration site family, member 1 / P04628* / P04426* / Wnt family member 1*  / reaction / complex
 ENSDARG00000002587 dpysl3 / Q52PJ5 / dihydropyrimidinase-like 3 / Q14195*  / reaction
 ENSDARG00000008818 hsf1 / heat shock transcription factor 1 / P38532* / Q00613* / heat shock factor 1*  / reaction
 ENSDARG00000103490 dpysl4 / dihydropyrimidinase-like 4 / O14531*  / reaction
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / reaction
 ENSDARG00000019328 plxna4 / plexin A4 / Q80UG2* / Q9HCM2*  / reaction
 ENSDARG00000056683 cdk5 / cyclin-dependent kinase 5 / P49615* / Q00535* / Cyclin-dependent-like kinase 5 *  / reaction
 ENSDARG00000045087 cdk5r1b / cyclin-dependent kinase 5, regulatory subunit 1b (p35) / Q15078* / P61809* / CDK5R1* / cyclin dependent kinase 5 regulatory subunit 1* / Cyclin-dependent kinase 5 activator 1 Cycl...  / reaction
 ENSDARG00000037916 cdk5r1a / cyclin-dependent kinase 5, regulatory subunit 1a (p35) / Q15078* / P61809* / CDK5R1* / cyclin dependent kinase 5 regulatory subunit 1* / Cyclin-dependent kinase 5 activator 1 Cycl...  / reaction
 ENSDARG00000102153 nrp1a / neuropilin 1a / NRP1* / O14786* / P97333* / neuropilin 1*  / reaction
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / reaction
 ENSDARG00000007172 plxna3 / plexin A3 / P51805* / P70208*  / reaction
 ENSDARG00000055552 dvl1b / dishevelled segment polarity protein 1b / DVL1* / P51141* / O14640* / Segment polarity DVL-1 * / dishevelled segment polarity protein 1*  / reaction / complex
 ENSDARG00000102964 axin1 / O15169*  / complex
 ENSDARG00000106062 fzd1 / frizzled class receptor 1 / Q9UP38*  / complex / reaction






 

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