ENSDARG00000007172


Danio rerio

Features
Gene ID: ENSDARG00000007172
  
Biological name :plxna3
  
Synonyms : plexin A3 / plxna3
  
Possible biological names infered from orthology : P51805 / P70208
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 9222684
Gene end: 9570511
  
Corresponding Affymetrix probe sets: Dr.15899.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000043999
NCBI entrez gene - 567422     See in Manteia.
RefSeq - NM_001098489
RefSeq Peptide - NP_001091959
swissprot - A0A0A0MPG5
ZFIN ID - ZDB-GENE-070613-1
Ensembl - ENSDARG00000007172
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P51805ENSG00000130827Homo sapiens
 P70208ENSMUSG00000031398Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
plxna1a / plexin A1a / PLXNA1* / Q9UIW2* / plexin A1*ENSDARG0000010545268
plxna4 / plexin A4 / Q80UG2* / Q9HCM2*ENSDARG0000001932861
LO018148.1 / PLXNA1* / Q9UIW2* / plexin A1*ENSDARG0000011482361
plxna2 / plexin A2 / O75051* / P70207*ENSDARG0000006037261
plxnb3 / plexin B3 / Q9QY40* / Q9ULL4*ENSDARG0000003299035
plxnb1b / plexin b1b / O43157* / PLXNB1* / plexin B1*ENSDARG0000001721134
plxnb2b / plexin b2b / O15031* / PLXNB2* / plexin B2*ENSDARG0000003698530
plxnb2a / plexin b2a / O15031* / B2RXS4* / PLXNB2* / plexin B2*ENSDARG0000000381130
plxnb1a / plexin b1a / PLXNB1* / O43157* / Q8CJH3* / plexin B1*ENSDARG0000007582128
plxnc1 / plexin C1 / O60486* / Q9QZC2*ENSDARG0000001527816
plxnb2a / plexin b2a / O15031* / B2RXS4* / PLXNB2* / plexin B2*ENSDARG000000947997
si:dkey-183c2.4 / B2RXS4* / O15031* / PLXNB2* / plexin B2*ENSDARG000000798927
si:ch211-127b11.1 / B2RXS4* / O15031* / PLXNB2* / plexin B2*ENSDARG000000770906
plxnd1 / plexin D1 / Q3UH93* / Q9Y4D7*ENSDARG000000860574


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR002909  IPT domain
 IPR008936  Rho GTPase activation protein
 IPR013548  Plexin, cytoplasmic RasGAP domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0017154 semaphorin receptor activity IEA


Pathways (from Reactome)
Pathway description
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000075 spinal cord spinal cord motor neuron malformed , abnormal
spinal cord primary motor neuron malformed , abnormal
spinal cord axon increased branchiness , abnormal
Show

 ZFA:0000664 cranial nerve VII cranial nerve VII malformed , abnormal
Show

 ZFA:0000697 cranial nerve V cranial nerve V malformed , abnormal
Show

 ZFA:0000705 ventral root ventral root mislocalised , abnormal
Show

 ZFA:0001056 myotome myotome CaP motoneuron hypoplastic , abnormal
Show

 ZFA:0001269 regenerating fin regenerating fin lepidotrichium segment decreased length , abnormal
regenerating fin decreased length , abnormal
Show

 ZFA:0005179 MiP motor neuron MiP motor neuron axon mislocalised , abnormal
MiP motor neuron axon increased branchiness , abnormal
Show

 ZFA:0005180 RoP motor neuron RoP motor neuron axon mislocalised , abnormal
RoP motor neuron axon increased branchiness , abnormal
Show

 ZFA:0009052 motor neuron motor neuron axon structure , abnormal
motor neuron axon increased amount , abnormal
motor neuron axon misrouted , abnormal
motor neuron axon increased branchiness , abnormal
Show

 ZFA:0009063 peripheral neuron peripheral neuron quality , abnormal
Show

 ZFA:0009243 CaP motoneuron CaP motoneuron axon decreased length , abnormal
CaP motoneuron axon increased branchiness , abnormal
CaP motoneuron axon collateral increased amount , abnormal
CaP motoneuron axon collateral mislocalised proximally , abnormal
Show

 ZFA:0009244 primary motor neuron primary motor neuron axon spatial pattern , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017803 gsk3b / glycogen synthase kinase 3 beta / P49841* / Q9WV60*  / reaction
 ENSDARG00000103490 dpysl4 / dihydropyrimidinase-like 4 / O14531*  / reaction / complex
 ENSDARG00000002587 dpysl3 / Q52PJ5 / dihydropyrimidinase-like 3 / Q14195*  / reaction / complex
 ENSDARG00000102153 nrp1a / neuropilin 1a / NRP1* / O14786* / P97333* / neuropilin 1*  / complex
 ENSDARG00000016429 farp2 / FERM, RhoGEF and pleckstrin domain protein 2 / O94887* / Q91VS8* / FERM, ARH/RhoGEF and pleckstrin domain protein 2* / FERM, ARHGEF and pleckstrin domain-containing protein 2 *  / complex
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSDARG00000045087 cdk5r1b / cyclin-dependent kinase 5, regulatory subunit 1b (p35) / Q15078* / P61809* / CDK5R1* / cyclin dependent kinase 5 regulatory subunit 1* / Cyclin-dependent kinase 5 activator 1 Cycl...  / complex
 ENSDARG00000056683 cdk5 / cyclin-dependent kinase 5 / P49615* / Q00535* / Cyclin-dependent-like kinase 5 *  / complex
 ENSDARG00000052468 si:dkeyp-80c12.7 / GSK3B (1 of many) / GSK3B* / P49841* / Q9WV60* / glycogen synthase kinase 3 beta*  / reaction
 ENSDARG00000037916 cdk5r1a / cyclin-dependent kinase 5, regulatory subunit 1a (p35) / Q15078* / P61809* / CDK5R1* / cyclin dependent kinase 5 regulatory subunit 1* / Cyclin-dependent kinase 5 activator 1 Cycl...  / complex
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSDARG00000011449 fes / FES proto-oncogene, tyrosine kinase / P07332* / P16879* / Tyrosine-protein kinase Fes/Fps *  / complex






 

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