ENSDARG00000060372


Danio rerio

Features
Gene ID: ENSDARG00000060372
  
Biological name :plxna2
  
Synonyms : plexin A2 / plxna2
  
Possible biological names infered from orthology : O75051 / P70207
  
Species: Danio rerio
  
Chr. number: 23
Strand: -1
Band:
Gene start: 32579495
Gene end: 33038423
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000120287
Ensembl peptide - ENSDARP00000152904
Ensembl peptide - ENSDARP00000157594
NCBI entrez gene - 561285     See in Manteia.
swissprot - F1QCL2
ZFIN ID - ZDB-GENE-090311-6
Ensembl - ENSDARG00000060372
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PLXNA2ENSGALG00000001264Gallus gallus
 O75051ENSG00000076356Homo sapiens
 P70207ENSMUSG00000026640Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
plxna4 / plexin A4 / Q80UG2* / Q9HCM2*ENSDARG0000001932867
plxna1a / plexin A1a / PLXNA1* / Q9UIW2* / plexin A1*ENSDARG0000010545263
plxna3 / plexin A3 / P51805* / P70208*ENSDARG0000000717261
LO018148.1 / PLXNA1* / Q9UIW2* / plexin A1*ENSDARG0000011482357
plxnb1b / plexin b1b / O43157* / PLXNB1* / plexin B1*ENSDARG0000001721134
plxnb3 / plexin B3 / Q9QY40* / Q9ULL4*ENSDARG0000003299033
plxnb2a / plexin b2a / O15031* / B2RXS4* / PLXNB2* / plexin B2*ENSDARG0000000381130
plxnb2b / plexin b2b / O15031* / PLXNB2* / plexin B2*ENSDARG0000003698530
plxnb1a / plexin b1a / PLXNB1* / O43157* / Q8CJH3* / plexin B1*ENSDARG0000007582128
plxnc1 / plexin C1 / O60486* / Q9QZC2*ENSDARG0000001527816
si:dkey-183c2.4 / B2RXS4* / O15031* / PLXNB2* / plexin B2*ENSDARG000000798928
plxnb2a / plexin b2a / O15031* / B2RXS4* / PLXNB2* / plexin B2*ENSDARG000000947997
si:ch211-127b11.1 / B2RXS4* / O15031* / PLXNB2* / plexin B2*ENSDARG000000770906
plxnd1 / plexin D1 / Q3UH93* / Q9Y4D7*ENSDARG000000860574


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR002909  IPT domain
 IPR008936  Rho GTPase activation protein
 IPR013548  Plexin, cytoplasmic RasGAP domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR031148  Plexin family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003403 optic vesicle formation IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0021785 branchiomotor neuron axon guidance IBA
 biological_processGO:0048841 regulation of axon extension involved in axon guidance IBA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0017154 semaphorin receptor activity IEA


Pathways (from Reactome)
Pathway description
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000050 optic vesicle optic vesicle regionalization decreased process quality , abnormal
optic vesicle decreased size , abnormal
optic vesicle cell mislocalised medially , abnormal
optic vesicle edge shape , abnormal
optic vesicle looseness , abnormal
optic vesicle cell mislocalised , abnormal
optic vesicle unstructured , abnormal
optic vesicle apoptotic process increased occurrence , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000128 midbrain midbrain physical object quality , abnormal
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 ZFA:0001094 whole organism whole organism increased amount , abnormal
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 ZFA:0001202 optic cup optic cup cell proliferation decreased occurrence , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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